Identification of hybrid amyloid strains assembled from amyloid-β and human islet amyloid polypeptide
Rongrong Wu,
Zengkai Wang,
Zili Jia
et al.
Abstract:Cross-fibrillation of amyloid-β (Aβ) peptides and human islet amyloid polypeptides (hIAPP) has revealed a close correlation between Alzheimer’s disease (AD) and type 2 diabetes (T2D). Importantly, different amyloid strains are likely to lead to the clinical pathological heterogeneity of degenerative diseases due to toxicity. However, given the complicated cross-interactions between different amyloid peptides, it is still challenging to identify the polymorphism of the hybrid amyloid strains and reveal mechanis… Show more
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