Nanomaterials made of non-toxic metallic sulfides: A systematic review of their potential biomedical applications

Argueta-Figueroa, Liliana; Martínez-Alvarez, Omar; Santos‐Cruz, J.; García-Contreras, René; Acosta-Torres, Laura Susana; Fuente-Hernández, Javier de la; Arenas‐Arrocena, Ma. Concepción

doi:10.1016/j.msec.2017.02.120

Cited by 61 publications

(33 citation statements)

References 101 publications

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“…Reported crystal structures of iron sulfide are displayed in Figure 1 (Fleet, 1971 ; Argueta-Figueroa et al, 2017 ). FeS possesses a tetragonal layered structure in which the iron atoms are linked through tetrahedral coordination to four equidistant sulfur atoms.…”

Section: Type and Structure Of Iron Sulfidementioning

confidence: 99%

Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications

2020

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Nano-sized iron sulfides have attracted intense research interest due to the variety of their types, structures, and physicochemical properties. In particular, nano-sized iron sulfides exhibit enzyme-like activity by mimicking natural enzymes that depend on an iron-sulfur cluster as cofactor, extending their potential for applications in biomedicine. The present review principally summarizes the synthesis, properties and applications in biomedical fields, demonstrating that nano-sized iron sulfides have considerable potential for improving human health and quality of life.

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Section: Type and Structure Of Iron Sulfidementioning

confidence: 99%

Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications

2020

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“…Pyrite iron disulphide has been mainly used as an absorbing semiconductor in solar cells [12], as well as for stripping mercury [14] and removing industrial pollutants [22]. According to a systematic review recently published by our group [23] concerning nanomaterials made of non-toxic metallic sulphide and their potential biomedical applications, magnetic greigite iron sulphide is a candidate for glucose detection and photothermal activity, among other uses. However, only one report referring to greigite iron sulphide/silver composites (Fe 3 S 4 /Ag) presented bacteriostatic effects against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), at 86.2% and 90.6%, respectively, and this was attributed to the presence of silver metal [24].…”

Section: Introductionmentioning

confidence: 99%

Colloidal synthesis of biocompatible iron disulphide nanocrystals

Santos‐Cruz

Núñez-Anita

Mayén-Hernández

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The aim of this research was to synthesis biocompatible iron disulphide nanocrystals at different reaction temperatures using the colloidal synthesis methodology. Synthesis was conducted at the 220-240 °C range of reaction temperatures at intervals of 5 °C in an inert argon atmosphere. The toxicity of iron disulphide nanocrystals was evaluated in vitro using mouse fibroblast cell line. Two complementary assays were conducted: the first to evaluate cell viability of the fibroblast via an MTT assay and the second to determine the preservation of fibroblast nuclei integrity through DAPI staining, which labels nuclear DNA in fluorescence microscopes. Through TEM and HRTEM, we observed a cubic morphology of pyrite iron disulphide nanocrystals ranging in sizes 25-50 nm (225 °C), 50-70 nm (230 °C) and >70 nm (235 °C). Through X-ray diffraction, we observed a mixture of pyrite and pyrrohotite in the samples synthesized at 225 °C and 240 °C, showing the best photocatalytic activity at 80% and 65%, respectively, for the degradation of methylene blue after 120 minutes. In all experimental groups, iron disulphide nanocrystals were biocompatible, i.e. no statistically significant differences were observed between experimental groups as shown in a one-way ANOVA and Tukey's test. Based on all of these results, we recommend non-cytotoxic semiconductor iron sulphide nanocrystals for biomedical applications.

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“…The potential for NMs to translocate to distal organs following a variety of exposure routes is a reality, with the liver shown to accumulate a large proportion of the total or translocated dose (Antunes et al 2017;Argueta-Figueroa et al 2017;Lim et al 2017). This clearly highlights the necessity for a thorough investigation of the impact of NM exposure to normal liver function.…”

Section: Discussionmentioning

confidence: 99%

A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs

Kermanizadeh

Powell

Stone

2020

Journal of Toxicology and Environmental Health, Part B

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The liver is one of the most important multi-functional organs in the human body. Amongst various crucial functions, it is the main detoxification center and predominantly implicated in the clearance of xenobiotics potentially including particulates that reach this organ. It is now well established that a significant quantity of injected, ingested or inhaled nanomaterials (NMs) translocate from primary exposure sites and accumulate in liver. This review aimed to summarize and discuss the progress made in the field of hepatic nanotoxicology, and crucially highlight knowledge gaps that still exist. Key considerations include The review offers a number of important suggestions for the future of hepatic nanotoxicology study design. This is of great significance as its findings are highly relevant due to the development of more advanced in vitro, and in silico models aiming to improve physiologically relevant toxicological testing strategies and bridging the gap between in vitro and in vivo experimentation.

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Nanomaterials made of non-toxic metallic sulfides: A systematic review of their potential biomedical applications

Cited by 61 publications

References 101 publications

Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications

Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications

Colloidal synthesis of biocompatible iron disulphide nanocrystals

A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs

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