Nanomaterials, Inflammation, and Tissue Engineering

Padmanabhan, Jagannath; Kyriakides, Themis R.

doi:10.1002/wnan.1320

Cited by 96 publications

(84 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PCL is a synthetic polyester that naturally degrades by hydrolysis of its ester linkages in physiological conditions. Nanoporous PCL in vivo has been shown to exacerbate the inflammatory formation of fibrous capsules (i.e., via the foreign body response) . Yet, PCL has been shown to elicit several types of immunomodulatory effects that are form and size dependent in vitro .…”

Section: Immunomodulatory Materialsmentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

View full text Add to dashboard Cite

Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

show abstract

Section: Immunomodulatory Materialsmentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is known that surface nanotopography can play an important role in regulating cellular responses [8,[41][42][43][44][45]; however model systems where these physiological responses can be studied in vivo are lacking. In the following study, we demonstrate the preparation of hybrid polymer/metal nanoparticles with well-defined nanotopography and chemistry, and their application in an in vivo model of acute biomaterial-induced inflammation.…”

Section: Introductionmentioning

confidence: 99%

Hybrid core/shell microparticles and their use for understanding biological processes

Bachhuka

Christo

Cavallaro

et al. 2015

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

Hybrid micro and nanoparticles have become a topic of intense research in recent years. This is due to the special properties of these materials that open new avenues in advanced applications. Herein, we report a novel method for the generation of hybrid particles utilising plasma polymerization. Poly (methyl methacrylate) (PMMA) beads were first coated with a thin allylamine based plasma polymer layer. Gold nanoparticles of engineered size and surface structure were then attached in a controlled manner to the plasma polymer coated beads. To generate uniform chemistry on the outermost surface and to preserve the nanotopography, we deposited a 5-10 nm thin layer of Acpp. We demonstrated that these particles can be utilized in in vivo models to interrogate important biological phenomena. Specifically, we used them in mice to study the inflammatory and foreign body responses to surface nanotopography. The data strongly indicates that surface nanotopography and chemistry can modulate collagen production and the number of adhering immune cells. The method for generating hybrid particles reported here is solvent free and can open new opportunities in fields such as tissue engineering, drug delivery, biosensors, and regenerative medicine.

show abstract

“…Among them, nanomaterials have attracted increasing interests due to their unique properties in regulating cell behavior at the molecular level. When compared to bulk materials, nanomaterials exhibit a drastic increase in surface area, effective stiffness, and surface area to volume ratio, leading to scaffolds exhibiting favorable physiochemical properties (Padmanabhan and Kyriakides 2015 ). Nanomaterials can be tuned to respond to specifi c cell microenvironment and interact with cells at the molecular and supra-molecular level (Gilmore et al 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Neural Engineering

2016

View full text Add to dashboard Cite

Nanomaterials, Inflammation, and Tissue Engineering

Cited by 96 publications

References 116 publications

Materials for Immunotherapy

Materials for Immunotherapy

Hybrid core/shell microparticles and their use for understanding biological processes

Neural Engineering

Contact Info

Product

Resources

About