Nanomaterials for Neural Regeneration

Sever, Melike; Mammadov, Busra; Gecer, Mevhibe; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1002/9781118987483.ch3

Cited by 3 publications

(4 citation statements)

References 109 publications

(116 reference statements)

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“…Efforts to incorporate nanomaterials in tissue engineering have highlighted superior mechanical, catalytic, conductive, optical, magnetic and cytocompatible properties compared to traditional materials, and much promise has been shown in engineering biocomposites for neural tissue. [111,112] …”

Section: Diagnostic and Therapeutic Applications Of Nanotechnology Inmentioning

confidence: 99%

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Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Kumar

Tan

Wong

et al. 2017

Adv Funct Materials

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Unlocking the secrets of the brain is a task fraught with complexity and challenge – not least due to the intricacy of the circuits involved. With advancements in the scale and precision of scientific technologies, we are increasingly equipped to explore how these components interact to produce a vast range of outputs that constitute function and disease. Here, an insight is offered into key areas in which the marriage of neuroscience and nanotechnology has revolutionized the industry. The evolution of ever more sophisticated nanomaterials culminates in network-operant functionalized agents. In turn, these materials contribute to novel diagnostic and therapeutic strategies, including drug delivery, neuroprotection, neural regeneration, neuroimaging and neurosurgery. Further, the entrance of nanotechnology into future research arenas including optogenetics, molecular/ion sensing and monitoring, and piezoelectric effects is discussed. Finally, considerations in nanoneurotoxicity, the main barrier to clinical translation, are reviewed, and direction for future perspectives is provided.

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Section: Diagnostic and Therapeutic Applications Of Nanotechnology Inmentioning

confidence: 99%

“…[112] However, many still exhibit shortcomings at the point of application. Autografts are difficult to collect in sufficient quantities from patients and exhibit a theoretical risk of impairing donor site nerve function.…”

Section: Diagnostic and Therapeutic Applications Of Nanotechnology Inmentioning

confidence: 99%

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Kumar

Tan

Wong

et al. 2017

Adv Funct Materials

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“…2 Physical properties of the microenvironment are one of the most important aspects of regenerative materials and should be considered along the chemical and biological properties of the system when designing biomaterials for tissue engineering applications. 1 For in vitro studies, two-dimensional (2D) cell culture techniques are commonly used to study cell function and behavior, including cell attachment, proliferation, migration and differentiation, before the in vivo evaluation of the regenerative potential. However, while it is easy to control and manipulate the environment in 2D cell cultures, they are less compatible with in vivo systems and fail to mimic the native three-dimensional (3D) tissues.…”

Section: Introductionmentioning

confidence: 99%

Tenascin-C derived signaling induces neuronal differentiation in a three-dimensional peptide nanofiber gel

et al. 2018

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The development of new biomaterials mimicking the neuronal extracellular matrix (ECM) requires signals for the induction of neuronal differentiation and regeneration. In addition to the biological and chemical cues, the physical properties of the ECM should also be considered while designing regenerative materials for nervous tissue. In this study, we investigated the influence of the microenvironment on tenascin-C signaling using 2D surfaces and 3D scaffolds generated by a peptide amphiphile nanofiber gel with a tenascin-C derived peptide epitope (VFDNFVLK). While tenascin-C mimetic PA nanofibers significantly increased the length and number of neurites produced by PC12 cells on 2D cell culture, more extensive neurite outgrowth was observed in the 3D gel environment. PC12 cells encapsulated within the 3D tenascin-C mimetic peptide nanofiber gel also exhibited significantly increased expression of neural markers compared to the cells on 2D surfaces. Our results emphasize the synergistic effects of the 3D conformation of peptide nanofibers along with the tenascin-C signaling and growth factors on the neuronal differentiation of PC12 cells, which may further provide more tissue-like morphology for therapeutic applications.

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“…Dimensionality is another important parameter, and although two‐dimensional (2D) cell cultures are commonly used in differentiation studies, three‐dimensional cell cultures are important in vitro models to fill the gap between 2D cell culture experiments and in vivo studies. 3D models are especially important for studying the regeneration of neural tissue, which has a very low regeneration capacity that may be improved by closely mimicking the native extracellular matrix of neural cells to provide support and enhance the diffusion of oxygen and nutrients …”

Section: Introductionmentioning

confidence: 99%

Three‐Dimensional Laminin Mimetic Peptide Nanofiber Gels for In Vitro Neural Differentiation

Günay

Sever

Tekinay

et al. 2017

Biotechnology Journal

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The extracellular matrix (ECM) provides biochemical signals and structural support for cells, and its functional imitation is a fundamental aspect of biomaterial design for regenerative medicine applications. The stimulation of neural differentiation by a laminin protein-derived epitope in two-dimensional (2D) and three-dimensional (3D) environments is investigated. The 3D gel system is found to be superior to its 2D counterpart for the induction of neural differentiation, even in the absence of a crucial biological inducer in nerve growth factor (NGF). In addition, cells cultured in 3D gels exhibits a spherical morphology that is consistent with their form under in vivo conditions. Overall, the present study underlines the impact of bioactivity, dimension, and NGF addition, as well as the cooperative effects thereof, on the neural differentiation of PC-12 cells. These results underline the significance of 3D culture systems in the development of scaffolds that closely replicate in vivo environments for the formation of cellular organoid models in vitro.

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Nanomaterials for Neural Regeneration

Cited by 3 publications

References 109 publications

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Nanotechnology for Neuroscience: Promising Approaches for Diagnostics, Therapeutics and Brain Activity Mapping

Tenascin-C derived signaling induces neuronal differentiation in a three-dimensional peptide nanofiber gel

Three‐Dimensional Laminin Mimetic Peptide Nanofiber Gels for In Vitro Neural Differentiation

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