Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy

Zhang, Shiyong; Wang, Liying; Kang, Yan; Wu, Jun; Zhang, Ziji

doi:10.1016/j.actbio.2023.03.030

Cited by 17 publications

(10 citation statements)

References 192 publications

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“…Consequently, ROS plays a pivotal role in the trajectory and advancement of inflammatory processes, perpetuating their development and progression. [179,186] Current nanozymes only display special activities for given ROS rather than multiple ROS exist in inflammation diseases. Hence, Bao et al utilized PDA NPs to scavenge various species of ROS that generated in periodontitis, since PDA has plentiful reductive groups like catechol and imine.…”

Section: Antioxidant Therapymentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon us more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, we list the advances of biomaterials for ameliorating inflammatory bone loss. Additionally, we summarize the advantages and disadvantages of various biomaterials‐mediated strategies. Finally, we analyze the challenges and perspectives of biomaterials. This review aims to provide new possibilities for developing more advanced biomaterials towards inflammatory bone loss.This article is protected by copyright. All rights reserved

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Section: Antioxidant Therapymentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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“…5,6 The reactive oxygen species (ROS) including free radicals such as superoxide anions, hydroxyl radicals, and hydrogen peroxide (H 2 O 2 ) are produced during many physiological processes in the human body. 7 It should be noted that excessive ROS in pathological states tends to produce lipid peroxidation (LPO) and cause DNA damage, which not only induce oxidative stress and cell apoptosis but also activate proinflammatory signaling pathways to exacerbate the inflammatory response. 8,9 Typically, high-level inflammatory cytokines lead to a disruption of the balance between anti-inflammatory and proinflammatory pathways, resulting in cell apoptosis and articular cartilage degeneration.…”

Section: Introductionmentioning

confidence: 99%

“…The invasion of inflammation is closely associated with many diseases such as neurodegenerative diseases, pneumonia, atherosclerosis, and arthritis. − In particular, osteoarthritis (OA) causes severe pain and dysfunction in patients’ knees and has become one of the most disabling joint diseases in humans. The development of OA can be attributed to the degradation of articular cartilage and its extracellular matrix (ECM), synovial inflammation, and subchondral bone remodeling. , The reactive oxygen species (ROS) including free radicals such as superoxide anions, hydroxyl radicals, and hydrogen peroxide (H 2 O 2 ) are produced during many physiological processes in the human body . It should be noted that excessive ROS in pathological states tends to produce lipid peroxidation (LPO) and cause DNA damage, which not only induce oxidative stress and cell apoptosis but also activate proinflammatory signaling pathways to exacerbate the inflammatory response. , Typically, high-level inflammatory cytokines lead to a disruption of the balance between anti-inflammatory and proinflammatory pathways, resulting in cell apoptosis and articular cartilage degeneration .…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

Zhan,

Sun,

Wang

et al. 2024

ACS Nano

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Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design of a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded with azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN with a size of 268 nm are stable under physiological conditions, can be specifically taken up by macrophages through the FN-mediated targeting, and can be dissociated in the oxidative inflammatory microenvironment. The G4-TBP NPs-FN loaded with G4-TBP dendrimer having intrinsic anti-inflammatory property and FN having both anti-inflammatory and antioxidative properties display integrated functions of ROS scavenging, hypoxia attenuation, and macrophage M2 polarization, thus protecting macrophages from apoptosis and creating designed bone immune microenvironment for stem cell osteogenic differentiation. These characteristics of the G4-TBP NPs-FN lead to their effective treatment of an OA model in vivo to reduce pathological changes of joints including synovitis inhibition and cartilage matrix degradation and simultaneously promote osteogenic differentiation for bone repair. The developed nanomedicine formulation combining the advantages of both bioactive phosphorus dendrimers and FN to treat OA may be developed for immunomodulatory therapy of different inflammatory diseases.

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“…Inflammatory stimulation leads to an increase in the generation of free radicals, including reactive oxygen species (ROS) and reactive nitrogen species (RNS) [ 22 ]. The resultant imbalance between these free radicals and antioxidant systems is defined as oxidative stress [ 23 ]. Prior research has investigated the relationship between oxidative stress and ECM degradation [ 24 ].…”

Section: Introductionmentioning

confidence: 99%