A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM

Liu, Changxing; Sun, Yawei; Li, Dengju; Wang, Fan; Wang, Haojue; An, Senbo; Sun, Shui

doi:10.1016/j.mtbio.2024.101034

Materials Today Bio

2024

DOI: 10.1016/j.mtbio.2024.101034

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A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM

Changxing Liu,

Yawei Sun,

Dengju Li

et al.

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2024

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Regulating chondrocyte senescence through substrate stiffness modulation

Wang,

Dai,

Shen

et al. 2024

J of Applied Polymer Sci

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Chondrocytes, the resident cells of articular cartilage, play a vital role in tissue maintenance and regeneration. Recent studies have highlighted chondrocyte senescence as a key contributor to cartilage dysfunction. In this study, we investigated the influence of substrate stiffness on chondrocyte senescence using polydimethylsiloxane (PDMS) substrates with varying stiffness ratios (1:5, 1:20, and 1:60). After culturing chondrocytes on these substrates, we found that softer substrates (1:60) significantly reduced chondrocyte senescence, as evidenced by a decrease in senescence‐associated β‐galactosidase (SA‐β‐gal) activity by 33% compared with stiffer substrates (1:5). Furthermore, quantitative real‐time polymerase chain reaction (PCR) analysis revealed that chondrocytes cultured on softer substrates exhibited lower expression levels of senescence‐related genes (e.g., p16INK4a) and matrix‐degrading enzymes (e.g., MMP13). These findings suggest that substrate stiffness plays a critical role in regulating chondrocyte senescence and could potentially inform the design of scaffolds for cartilage tissue engineering.

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Regulating chondrocyte senescence through substrate stiffness modulation

Wang,

Dai,

Shen

et al. 2024

J of Applied Polymer Sci

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A multifunctional nanogel encapsulating layered double hydroxide for enhanced osteoarthritis treatment via protection of chondrocytes and ECM

Cited by 1 publication

References 52 publications

Regulating chondrocyte senescence through substrate stiffness modulation

Regulating chondrocyte senescence through substrate stiffness modulation

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