Nanomaterial based electrochemical sensors for in vitro detection of small molecule metabolites

Xiao, Fei; Wang, Lu; Duan, Hongwei

doi:10.1016/j.biotechadv.2016.01.006

Cited by 93 publications

(39 citation statements)

References 226 publications

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“…Motivated on outstanding sensing performances and transfer mechanism of biomimetic Murray MOFs, it is highly desirable to apply Cu 2 (NDC) 2 /PDHP in the sweat lactate and glucose sensing platform. And for wearable sweat sensors, flexibility substrate plays crucial roles in real‐time monitoring during continuous movement . The mechanical stability of Cu 2 (NDC) 2 /PDHP at different bending states has been studied.…”

Section: Resultsmentioning

confidence: 99%

Coffee Ring–Inspired Approach toward Oriented Self‐Assembly of Biomimetic Murray MOFs as Sweat Biosensor

Wang

Liu

et al. 2018

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The emergence of metal–organic frameworks (MOFs) has sparked intensive attention and opened up the possibility of “crystal engineering.” However, low conductivity, slow diffusion of guest molecules, as well as powder forms always hinder the development of MOF application, especially for biosensors and bioelectronics. Herein, a coffee ring–inspired strategy toward oriented self‐assembly of a biomimetic MOF film following Murray's law is proposed, which can effectively reduce the transfer resistance. The approach includes two types of self‐assembly, evaporation‐driven and heteroepitaxy self‐assembly, and endows the centimeter‐expanded MOF film with oriented macropores, mesopores, and micropores. The Murray MOF network enables greatly enhanced electrons and mass transfer efficiency for electrochemical sensing. Also, the newly discovered lactate and glucose sensing abilities in a wide pH hold striking potential in new generation of wearable sweat biosensors, miniature bioelectronics, and lab‐on‐a‐chip devices.

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Section: Resultsmentioning

confidence: 99%

Coffee Ring–Inspired Approach toward Oriented Self‐Assembly of Biomimetic Murray MOFs as Sweat Biosensor

Wang

Liu

et al. 2018

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“…The WE can be modified with nanomaterials for recognition ,,. The detection of relevant molecular analytes, such as small molecules, chemicals, metabolites, vitamins, amino acids, nutritional minerals, nucleic acids, healthy proteins, pesticides, herbicides can provide a legitimate answer to the expanding requirement for quick, specific, and also cost‐effective electrochemical sensors ,.…”

Section: Introductionmentioning

confidence: 99%

“…A range of techniques for target recognition and signal transduction have really made it possible for the development of a significant series of electrochemical assays. Conventional electrochemical sensor based on low surface area materials suffers from high overpotential, slow electron transfer kinetics, and diffusion/mass transfer limitation of analytes ,. To overcome these obstacles, modified electrode materials with high electrocatalytic efficiency are required.The present personal account is mainly targeted at the chemically modified electrodes involving transition metal oxides and zeolite‐based nanocomposite materials directed toward electroanalytical applications.…”

Section: Introductionmentioning

confidence: 99%

“…[34,35] The detection of relevant molecular analytes, such as small molecules, chemicals, metabolites, vitamins, amino acids, nutritional minerals, nucleic acids, healthy proteins, pesticides, herbicides can provide a legitimate answer to the expanding requirement for quick, specific, and also cost-effective electrochemical sensors. [34,35] A range of techniques for target recognition and signal transduction have really made it possible for the development of a significant series of electrochemical assays. Conventional electrochemical sensor based on low surface area materials suffers from high overpotential, slow electron transfer kinetics, and diffusion/mass transfer limitation of analytes.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Sensor Platforms Based on Nanostructured Metal Oxides, and Zeolite‐Based Materials

Prathap

Kaur

Srivastava

2018

The Chemical Record

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Electrochemical sensors have drawn significant attention over the last couple of decades because of their ability to improve detection of organic and inorganic analytes found in the field of biotechnology, environmental sciences, medicine, and food quality control. This personal account summarizes the state‐of‐art research carried out in the construction and evaluation of nanostructured metal oxides and zeolite based electrochemical sensors. Metal oxides and zeolite‐based nanomaterials have many unique and extraordinary properties such as tunable redox activity, surface functionalization ability, optimum conductivity, large surface area, biocompatibility and so forth. In this personal account, the current advances in electrochemical sensor applications of metal oxides, zeolite‐based nanomaterials, and their nanocomposites are described for the single and simultaneous determination of organic & inorganic contaminants present in water bodies, physiological bio‐molecules present in human blood & urine samples, and organic contaminants present in food materials.Moreover, concluding section focuses discussion on the future developments and applications of these materials in various emerging technologies.

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“…However, enzymes are less appreciated for pragmatic applications due to their instability, high cost and complex immobilization process. As an alternative approach, non-enzymatic electrodes modified with metal NPs have been introduced as advanced H 2 O 2 biosensor [33][34][35][36]. The metal nanoparticles are generally immobilized on the mesoporous materials by electrodeposition and solution process.…”

Section: Introductionmentioning

confidence: 99%

Non-covalent functionalization of CVD-grown graphene with Au nanoparticles for electrochemical sensing application

Shown

Ganguly

2016

J Nanostruct Chem

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Graphene is an one-atom thick two-dimensional (2D) transparent carbon sheet which has aroused potential interest for the ultrafast high-sensitive electronic device application. Functionalization of 2D graphene is one of the important aspects to manipulate its intrinsic properties achieving the requisite aptness for its booming applications. Here, a novel strategy for the noncovalent surface functionalization of 2D graphene layer has been proposed utilizing self-assemble monolayers (SAM) of 1,4-benzenedimethanethiol (BDMT) that can further anchor gold nanoparticles (AuNPs) on the graphene surface. Raman spectroscopy and contact angle measurements confirm the SAM modification on graphene surface. AFM and XPS verify the anchoring of AuNPs on the graphene surface. Furthermore, the AuNPs-anchored BDMT-modified graphene (AuNPs/BDMT/G) electrode is explored for highly sensitive electrochemical detection of H 2 O 2 , exhibiting an impressive detection limit of 1.8 lM (signal-to-noise ratio of 3).Electronic supplementary material The online version of this article

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Nanomaterial based electrochemical sensors for in vitro detection of small molecule metabolites

Cited by 93 publications

References 226 publications

Coffee Ring–Inspired Approach toward Oriented Self‐Assembly of Biomimetic Murray MOFs as Sweat Biosensor

Coffee Ring–Inspired Approach toward Oriented Self‐Assembly of Biomimetic Murray MOFs as Sweat Biosensor

Electrochemical Sensor Platforms Based on Nanostructured Metal Oxides, and Zeolite‐Based Materials

Non-covalent functionalization of CVD-grown graphene with Au nanoparticles for electrochemical sensing application

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