Nanoincorporation of curcumin in polymer-glycerosomes and evaluation of their in vitro–in vivo suitability as pulmonary delivery systems

Abstract

This work was aimed at deliver curcumin to lungs by its incorporation into innovative vesicles glycerosomes and polymer-glycerosomes, the latter obtained combining glycerosomes with two polymers: sodium hyaluronate and trimethyl chitosan.

Aerosol characterisation of nebulised liposomes co-loaded with erlotinib and genistein using an abbreviated cascade impactor method

“…This may predominantly result from the water evaporation effect during delivered throughout the impactor and/or liposome disruption after being delivered from nebulisers. A reduction in the size of vesicles deposited in the lower as opposed to higher stages of a full-impactor has been previously reported following nebulisation from an air-jet nebuliser (Manca et al 2015). Overall, it can be seen that there was no difference in size stability of nebulised liposomes delivered by air-jet and vibratingmesh nebuliser.…”

“…However, there are only minor drug losses even with vesicle disruption during nebulisation for hydrophobic drugs since most of lipophilic drugs are still entrapped within the liposomal bilayer (Cipolla et al, 2013;Elhissi et al, 2011;Elhissi et al, 2013). Furthermore, the destabilising forces within such devices had shown no significant impact on particle aggregation and drug leakage when the physical stability of liposomes with respect to size of deposited liposomes across the different stages of the Next Generation Impactor (NGI) (Manca et al, 2015).…”

Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin

“…In recent years, many efforts have been made to increase the potential of curcumin for health promotion and disease prevention, by improving its bioavailability. A large number of research works have focused on innovative formulations intended for oral, pulmonary and topical delivery of curcumin, using innovative ingredients or carrier systems specific for the selected target [8][9][10]. The oral administration of curcumin in innovative carriers represents the most attractive strategy, because it can ensure local delivery and accumulation in the intestines, and improve the systemic biovailability at the same time [11,12].…”

Comparative Oral Absorption of Curcumin in a Natural Turmeric Matrix with Two Other Curcumin Formulations: An Open‐label Parallel‐arm Study

“…These include formulations with nanoparticles (Basniwal et al ., ; Yallapu et al ., ; Yallapu et al ., ), liposomes (Chen et al ., ; Liu et al ., ; Ranjan et al ., ), micelles (Kocher et al ., ; Li et al ., ; Schiborr et al ., ; Wang et al ., ), or interaction with macromolecules such as gelatin (Madhusudana Rao et al ., ) and polysaccharides as galactomannans (Da‐Lozzo et al ., ) and cyclodextrin (Dhule et al ., ; Mangolim et al ., ; Yallapu et al ., ). In addition, curcumin formulations involving hyaluronate vesicles and liposomes (Catalan‐Latorre et al ., ; Manca et al ., ) as well as polymer glycerosomes (Manca et al ., ) have been developed and studied. The absorption of various commercial curcuminoid products, including the phospholipid and volatile oil formulations used in the current study, has been compared on a relative mass efficiency basis (Douglass and Clouatre, ).…”