Nanographene enfolded AuNPs sophisticatedly synchronized polycaprolactone based electrospun nanofibre scaffold for peripheral nerve regeneration

Jaswal, Richa; Shrestha, Sita; Shrestha, Bishnu Kumar; Kumar, Dinesh; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.msec.2020.111213

Cited by 39 publications

(24 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GO or rGO can be coated on particles such as Au NPs to increase surface functionalization and decrease the adverse effects of residual chemicals related to NPs synthesis. The size of NPs typically selected is below 100 nm to increase interaction with cells, even at the fundamental molecular level [ 48 ]. The concentration of 0.005% of rGo-Au NPs leads to a one-fold increase in neurite growth.…”

Section: Tissue-engineered Scaffolds With Gbm and Neural Tissuesmentioning

confidence: 99%

“…The concentration of 0.005% of rGo-Au NPs leads to a one-fold increase in neurite growth. The electrical conductivity of rGo-Au NPs increased from 157.5 μs/cm (Au-NPs) to 384 μs/cm, which referred to the removal of excess oxygen ions and made electron transportation ultrafast in rGO with an inherent electron mobility limit [ 48 ]. In another study, the rGO-Au NPs were incorporated into the polyhydroxyl alkanoate (PHA) fibers, and the study endorsed the SCs proliferation as well as migration under applying 100 mv/cm electrical stimulation (ES) [ 49 ].…”

Section: Tissue-engineered Scaffolds With Gbm and Neural Tissuesmentioning

confidence: 99%

See 1 more Smart Citation

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

et al. 2021

View full text Add to dashboard Cite

Peripheral nerve injury is a common medical condition that has a great impact on patient quality of life. Currently, surgical management is considered to be a gold standard first-line treatment; however, is often not successful and requires further surgical procedures. Commercially available FDA- and CE- approved decellularized nerve conduits offer considerable benefits to patients suffering from a completely transected nerve but they fail to support neural regeneration in gaps >30 mm. To address this unmet clinical need, current research is focused on biomaterial-based therapies to regenerate dysfunctional neural tissues, specifically damaged peripheral nerve, and spinal cord. Recently, attention has been paid to the capability of graphene-based materials (GBMs) to develop bifunctional scaffolds for promoting nerve regeneration, often via supporting enhanced neural differentiation. The unique features of GBMs have been applied to fabricate an electroactive conductive surface in order to direct stem cells and improve neural proliferation and differentiation. The use of GBMs for nerve tissue engineering (NTE) is considered an emerging technology bringing hope to peripheral nerve injury repair, with some products already in preclinical stages. This review assesses the last six years of research in the field of GBMs application in NTE, focusing on the fabrication and effects of GBMs for neurogenesis in various scaffold forms, including electrospun fibres, films, hydrogels, foams, 3D printing, and bioprinting.

show abstract

Section: Tissue-engineered Scaffolds With Gbm and Neural Tissuesmentioning

confidence: 99%

Section: Tissue-engineered Scaffolds With Gbm and Neural Tissuesmentioning

confidence: 99%

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Electrospinning is a multi-purpose and cost-effective process for producing non-woven micro/nanofibers, which can provide an excellent ECM-like environment for tissue and cell growth [ 57 , 58 ]. Electrospun fibers can meet various structural requirements for tissue engineering scaffolds, such as porosity, pores that communicate with each other, adjustable void size, functional filaments, and adjustable morphology [ 59 , 60 , 61 ]. Electrospinning is a standard method for the preparation of micro-nano fiber [ 62 ].…”

Section: Conduit Spatial Structure and Fillersmentioning

confidence: 99%

Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction

Zhang

Zhou

et al. 2021

Molecules

View full text Add to dashboard Cite

The nervous system is a significant part of the human body, and peripheral nerve injury caused by trauma can cause various functional disorders. When the broken end defect is large and cannot be repaired by direct suture, small gap sutures of nerve conduits can effectively replace nerve transplantation and avoid the side effect of donor area disorders. There are many choices for nerve conduits, and natural materials and synthetic polymers have their advantages. Among them, the nerve scaffold should meet the requirements of good degradability, biocompatibility, promoting axon growth, supporting axon expansion and regeneration, and higher cell adhesion. Polymer biological scaffolds can change some shortcomings of raw materials by using electrospinning filling technology and surface modification technology to make them more suitable for nerve regeneration. Therefore, polymer scaffolds have a substantial prospect in the field of biomedicine in future. This paper reviews the application of nerve conduits in the field of repairing peripheral nerve injury, and we discuss the latest progress of materials and fabrication techniques of these polymer scaffolds.

show abstract

“…Gold nanoparticles (AuNPs) are metallic agents that have gained attention in neural tissue engineering treatments owing to providing enhanced cellular response and mechanical features of the scaffolds (Saderi et al 2018;Afjeh-Dana et al 2019;Jaswal et al 2020). In addition, AuNPs stimulate axonal elongation and sprouting axons.…”

Section: Nerve Tissue Engineering Scaffoldsmentioning

confidence: 99%

Electrospun Porous Biobased Polymer Mats for Biomedical Applications

Parın

Terzioğlu

2021

Advanced Functional Porous Materials

View full text Add to dashboard Cite

The electrospinning method provides fabrication of nonwoven mats from nano to micrometers in size with controllable pores. Porous electrospun scaffolds have attracted increasing attention in biomedical applications especially due to their ability to mimic the extracellular matrix. This chapter presents a comprehensive overview of the advancements in the last five years through the design and preparation of porous biobased polymer mats using the electrospinning method for biomedical applications. Firstly, fundamentals of the electrospinning process are presented and followed by a discussion of the possible biomedical applications of micro-and nanostructured porous mats for drug delivery, wound dressing, tissue engineering, and other applications. Various crucial points for limitations and possible future trends are presented.

show abstract

Nanographene enfolded AuNPs sophisticatedly synchronized polycaprolactone based electrospun nanofibre scaffold for peripheral nerve regeneration

Cited by 39 publications

References 79 publications

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

Graphene-Based Materials Prove to Be a Promising Candidate for Nerve Regeneration Following Peripheral Nerve Injury

Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction

Electrospun Porous Biobased Polymer Mats for Biomedical Applications

Contact Info

Product

Resources

About