Electrospun Porous Biobased Polymer Mats for Biomedical Applications

Parın, Fatma Nur; Terzioğlu, Pınar

doi:10.1007/978-3-030-85397-6_18

Cited by 5 publications

(1 citation statement)

References 281 publications

(309 reference statements)

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“…Nevertheless, using solid-lipid nanoparticles or the development of encapsulating drugs via core-shell nanofibers is required for controlled drug delivery phenomena. 2019) have reported that the core-shell nanofibers they have fabricated may provide a synergistic effect for skin cancer [80]. In the study, chitosan (CS)-loaded PCL was used as a shell part, while the core part was consisted of poly(N-vinyl-2-pyrrolidone) (PVP) with 5-fluorouracil (5-FU).…”

Section: Anticancer Drugs Containing Nanofibrous Scaffoldsmentioning

confidence: 99%

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Parın

2024

JIENS

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Drug delivery systems perform to improve the drug's efficacy and heal the affected region. Electrospun nanofibers are strong drug carriers as a scaffold due to their high specific surface area, easy processing, lightweight material. Fibrous scaffolds encapsulating functional bioactive agents are important for drug delivery applications, and they show higher encapsulation efficiency and higher drug loading capacity than various types of carrier materials such as hydrogels, micro/nanobeads, films, conventional fibers, and sponges. In comparison to conventional electrospinning, bi-component electrospinning where drug loading does not occur largely on the surface of the polymer matrix, core-shell nanofibers showed delayed release and a decrease in burst release because the drug was loaded into the core layer. The purpose of this mini-review is to investigate the production and applications of the drug-loaded bi-component nanofibers in structure core-shell, side-by-side, hollow nanofibers, and also emulsion nanofibers using co-axial nozzles. Further, the parameters which influence of these electrospinning process, such as working conditions and polymer properties, as well as drug delivery profile of the resulting nanofibers, have been outlined briefly. The limited clinical studies on the nanofibers have been discussed. Eventually, perspectives on the problems, possibilities, and new approaches for electrospinning advancements have been presented, as well.

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Section: Anticancer Drugs Containing Nanofibrous Scaffoldsmentioning

confidence: 99%

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Parın

2024

JIENS

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Spirulina Biomass‐Loaded Thermoplastic Polyurethane/Polycaprolacton (TPU/PCL) Nanofibrous Mats: Fabrication, Characterization, and Antibacterial Activity as Potential Wound Healing

Parın

2022

ChemistrySelect

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The development of antibacterial products with therapeutic properties has become a popular human health trend. Herein, for the first time, we described an effective antibacterial thermoplastic polyurethane/polycaprolacton (TPU/PCL) composite nanofibers loaded with the spirulina biomass by electrospinning method for wound care applications. The chemical, microstructural, mechanical, wettability properties and antibacterial activities of produced electrospun TPU/PCL/spirulina fibers with varied spirulina concentrations (1, 3, and 5 %, w/v to polymer solution) were investigated by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), UV-VIS Spectroscopy, optical tensiometer and tensile testing machine. The SEM micrographs revealed that all resultant fibers have an average fiber diameter of 228-312 nm and a significant porosity (86-90 %). FT-IR spectrum pointed out no chemical bonding between spirulina and polymer matrixes.Increasing the spirulina content caused an increased swelling capacity of the nanofibers. Furthermore, TPU/PCL/spirulina samples indicated superhydrophilic property with contact angle values almost 36°, 0°, and 0°, respectively. The resultant TPU/PCL/spirulina fibers, released 36.89 ppm, 59.4 ppm, and 209.1 ppm of the spirulina after 8 hours, respectively and showing the effect of interactions between the TPU/PCL matrix and the spirulina on its release of the TPU/PCL matrix. Fluid absorption value have increased as incorporation of spirulina into the polymer matrix. All TPU/PCL/spirulina fibers and spirulina have antibacterial efficiency against E.colibacteria.TPU/ PCL nanofiber with the highest amount of spirulina (5 %) has the highest tensile strength with 3.89 � 0.19 MPa.The electrospun TPU/PCL/spirulina nanofibers appear to be a potential candidate material for tissue engineering and wound care applications, based on our results.

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3D and 4D Bioprinting Technology for Tissue Engineering Applications

Parın

2023

Interaction of Nanomaterials With Living Cells

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Electrospun Porous Biobased Polymer Mats for Biomedical Applications

Cited by 5 publications

References 281 publications

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Mini-review of the bi-component nanofibrous scaffolds and drug delivery applications

Spirulina Biomass‐Loaded Thermoplastic Polyurethane/Polycaprolacton (TPU/PCL) Nanofibrous Mats: Fabrication, Characterization, and Antibacterial Activity as Potential Wound Healing

3D and 4D Bioprinting Technology for Tissue Engineering Applications

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