Nanogold-loaded chitosan nanocomposites for pH/light-responsive drug release and synergistic chemo-photothermal cancer therapy

Salem, Dina S.; Hegazy, Salem F.; Obayya, S. S. A.

doi:10.1016/j.colcom.2021.100361

Cited by 21 publications

(12 citation statements)

References 53 publications

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“…However, the photothermal conversion efficiency of such system is relatively low—it took 7 min for their samples to reach 55.5 °C under 1W/cm 2 NIR laser irradiation. Salem et al also developed nanogold-loaded CS nanocomposites for drug release and chemo-photothermal cancer therapy applications [ 65 ]. Yet their best sample only reached the therapeutic temperature window after ~10 min of irradiation using a 532 nm laser (200 mW).…”

Section: Resultsmentioning

confidence: 99%

AuNP/Chitosan Nanocomposites Synthesized through Plasma Induced Liquid Chemistry and Their Applications in Photothermal Induced Bacteria Eradication

et al. 2022

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In this work, a facile direct current atmospheric pressure micro-plasma (APM) technology was deployed for the synthesis of functional gold nanoparticle/chitosan (AuNP/CS) nanocomposites for the first time. Different experimental parameters, such as metal salt precursor concentration and chitosan viscosity, have been investigated to understand their effects on the resulting nanocomposite structures and properties. The nanocomposites were fully characterized using a wide range of material characterization techniques such as UV–vis, transmission electron microscope (TEM), Fourier transform infrared (FTIR) spectra and X-ray photoelectron spectroscopy (XPS) analyses. Potential reaction pathways have been proposed for the nanocomposite synthesis process. Finally, potential of the synthesized nanocomposites towards photothermal conversion and bacteria eradiation applications has been demonstrated. The results show that APM is a facile, rapid and versatile technique for the synthesis of AuNP/CS functional nanocomposites. Through this work, a more in-depth understanding of the multi-phase system (consisting of gas, plasma, liquid and solid) has been established and such understanding could shine a light on the future design and fabrication of new functional nanocomposites deploying the APM technique.

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Section: Resultsmentioning

confidence: 99%

AuNP/Chitosan Nanocomposites Synthesized through Plasma Induced Liquid Chemistry and Their Applications in Photothermal Induced Bacteria Eradication

et al. 2022

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“…Gold nanospheres, as a kind of photo-absorbing agent, can generate heat from optical light energy for photothermal antitumor therapy. Salem et al [133] ) between positively amino groups of CS and negatively charged TPP groups is built via the ionic gelation method. The hydrogen bond interaction (…”

Section: Gold Nanoparticles (Au Nps)mentioning

confidence: 99%

Section: Gold Nanoparticles (Au Nps)mentioning

confidence: 99%

“…External stimuli NPs: External stimuli such as light [133], ultrasound [157], heat [39], and magnetic/electrical fields [152] affect the conformation or configuration of CS in the diseased tissue. These stimuli can be applied to improve cargo release into the diseased area to treat cancer, heart attack, and neurodegenerative diseases including Alzheimer's and Parkinson's.…”

Section: Stimuli Responsive Chitosan Chitosan Nanoparticles and Nanocompositesmentioning

confidence: 99%

“…Electrostatic interaction () between positively amino groups of CS and negatively charged TPP groups is built via the ionic gelation method. The hydrogen bond interaction () occurs between the hydrogen atom and a highly electronegative atom as O or N atom[133]. Reproduced with permission from Elsevier (Copyright©2021).…”

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Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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pH/chitinase dual stimuli‐responsive essential oil‐delivery system based on mesoporous silica nanoparticles for control of rice blast

Ding,

Yuan,

et al. 2024

Pest Management Science

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BACKGROUNDOwing to their surface modifiability, smart mesoporous silica nanoparticles (MSNs) can be designed to respond to plant disease‐microenvironmental stimuli, thereby achieving on‐demand release of active ingredients to control disease by effectively improving citral (CT) stability.RESULTSA pH/chitinase dual stimuli‐responsive essential oil‐delivery system (CT@HMS@CH/TA) was successfully fabricated by encapsulating CT in hollow mesoporous silica (HMS), and coating with tannic acid and chitosan within HMS by using the layer‐by‐layer assembly technique (LbL). CT@HMS@CH/TA with an average particle size of 125.12 ± 0.12 nm and a hollow mesoporous nanostructure showed high CT‐loading efficiency (16.58% ± 0.17%). The photodegradation rate of CT@HMS@CH/TA under UV irradiation (48 h) was only 15.31%, indicating a 3.34‐fold UV stability improvement. CT@HMS@CH/TA exhibited a higher CT release rate in response to acidic pH and the presence of chitinase, simulating the prevailing conditions as Magnaporthe oryzae infection. Furthermore, CT@HMS@CH/TA exhibited better adhesion without affecting normal rice growth, significantly up‐regulating chitinase gene expression and enhancing chitinase activity on M. oryzae, thus enhancing CT antifungal activity.CONCLUSIONCT@HMS@CH/TA improved CT stability and showed intelligent, controlled release‐performance and higher antifungal efficacy, thus providing a new strategy for efficient application of essential oils for green control of rice blast disease.

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Nanogold-loaded chitosan nanocomposites for pH/light-responsive drug release and synergistic chemo-photothermal cancer therapy

Cited by 21 publications

References 53 publications

AuNP/Chitosan Nanocomposites Synthesized through Plasma Induced Liquid Chemistry and Their Applications in Photothermal Induced Bacteria Eradication

AuNP/Chitosan Nanocomposites Synthesized through Plasma Induced Liquid Chemistry and Their Applications in Photothermal Induced Bacteria Eradication

Advances in Chitosan-Based Nanoparticles for Drug Delivery

pH/chitinase dual stimuli‐responsive essential oil‐delivery system based on mesoporous silica nanoparticles for control of rice blast

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