AuNP/Chitosan Nanocomposites Synthesized through Plasma Induced Liquid Chemistry and Their Applications in Photothermal Induced Bacteria Eradication

Guo, Zhijun; Sun, Dan; Zhou, Xian; Xu, Huan; Huang, Yi-Zhou; Chu, Chenglin; Shen, Baolong

doi:10.3390/pharmaceutics14102147

Cited by 4 publications

(1 citation statement)

References 72 publications

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“…The biomedical field has paid close attention to gold nanoparticles (AuNPs), among other functional nanomaterials, because of their nontoxicity, biocompatibility, and ease of manufacture [16,17]. Additionally, silver nanoparticles (AgNPs) have been shown to have enough potential to treat cancer [18]. The physical, chemical, and biological properties of CS, when combined with AuNPs, AgNPs were widely utilized in various medicinal applications and drug delivery [19,20].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Study Medical Application of Nanocomposites Based on grafted Chitosan /Polyvinyl alcohol

Ruwaidah S.Saeed,

Widad Abed Shlaka,

El-Sayed Negim

2024

IHJPAS

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In the present study, synthesis of bis Schiff base [I, II] by reaction of one mole of terephthalaldehyde with two mole of 2-amino-5-mercapto-1,3,4-thiadiazole or 4-amino benzene thiol in the ethanol absolute, then compounds [I,II] were reacted with Na2CO3 of distilled H2O, then chloroacetic acid was added to yield compounds [III,IV]. O-chitosan derivatives [V,VI] were synthesized by reaction of chitosan with compounds [III,IV] in acidic media in distilled water according to the steps of Fischer. O–chitosan (grafted chitosan) [V,VI] was blended with synthetic polymer polyvinyl alcohol (PVA) to produce polymers [VII,VIII], then these polymers were blended with nano: Gold or Silver by using a hotplate stirrer for 3 hours to produce nanocomposites [IX- XII]. The synthesized polymers were identified using spectral analysis techniques, including FTIR,1H-NMR, and scanning electron microscope (SEM). Molecular docking was studied, where operations are used to predict the binding status of compounds with the enzyme and to calculate the free energy (ΔG) of the prepared compounds. Finally, the study of biological activities was screened via two types of bacteria. Also, the anti-cancer activity against human lung adenocarcinoma cells (A549) was studied and compared with standard cell line [REF(R7540) Rat Embryonic Fibroblasts] of some of the blended polymers and nanocomposites, then the acute toxicity test of some nanocomposites was performed.

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