Nanogel engineering for new nanobiomaterials: from chaperoning engineering to biomedical applications

Sasaki, Yoshihiro; Akiyoshi, Kazunari

doi:10.1002/tcr.201000008

Cited by 338 publications

(228 citation statements)

References 82 publications

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“…20,21 However, the stability of the micelle by the contribution of the weak noncovalent interactions is undesirable. 22 In previous reports, acid-sensitive CCM could not only load and deliver drugs more stably but also control and sustain the release of drugs by the breakage of acid-labile cross-linker in the core. 23,24 Folate receptors are overexpressed in most types of epithelium-related cancer cells, while being almost undetectable in healthy tissues or cells.…”

Section: Introductionmentioning

confidence: 99%

Folic acid-targeted disulfide-based cross-linking micelle for enhanced drug encapsulation stability and site-specific drug delivery against tumors

Zhou¹,

Yang²,

Wang³

et al. 2016

IJN

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Although the shortcomings of small molecular antitumor drugs were efficiently improved by being entrapped into nanosized vehicles, premature drug release and insufficient tumor targeting demand innovative approaches that boost the stability and tumor responsiveness of drug-loaded nanocarriers. Here, we show the use of the core cross-linking method to generate a micelle with enhanced drug encapsulation ability and sensitivity of drug release in tumor. This kind of micelle could increase curcumin (Cur) delivery to HeLa cells in vitro and improve tumor accumulation in vivo. We designed and synthesized the core cross-linked micelle (CCM) with polyethylene glycol and folic acid-polyethylene glycol as the hydrophilic units, pyridyldisulfide as the cross-linkable and hydrophobic unit, and disulfide bond as the cross-linker. CCM showed spherical shape with a diameter of 91.2 nm by the characterization of dynamic light scattering and transmission electron microscope. Attributed to the core cross-linking, drug-loaded CCM displayed higher Nile Red or Cur-encapsulated stability and better sensitivity to glutathione than noncross-linked micelle (NCM). Cellular uptake and in vitro antitumor studies proved the enhanced endocytosis and better cytotoxicity of CCM-Cur against HeLa cells, which had a high level of glutathione. Meanwhile, the folate receptor-mediated drug delivery (FA-CCM-Cur) further enhanced the endocytosis and cytotoxicity. Ex vivo imaging studies showed that CCM-Cur and FA-CCM-Cur possessed higher tumor accumulation until 24 hours after injection. Concretely, FA-CCM-Cur exhibited the highest tumor accumulation with 1.7-fold of noncross-linked micelle Cur and 2.8-fold of free Cur. By combining cross-linking of the core with active tumor targeting of FA, we demonstrated a new and effective way to design nanocarriers for enhanced drug encapsulation, smart tumor responsiveness, and elevated tumor accumulation.

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Section: Introductionmentioning

confidence: 99%

Folic acid-targeted disulfide-based cross-linking micelle for enhanced drug encapsulation stability and site-specific drug delivery against tumors

Zhou¹,

Yang²,

Wang³

et al. 2016

IJN

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“…Nanogels can contain and protect drugs (and nucleotide therapeutics) and regulate their release by incorporating high-affinity functional groups, stimuli-responsive conformations and biodegradable bonds into the polymeric network (Vinogradov, 2007;Kabanov & Vinogradov, 2009;Sasaki & Akiyoshi, 2010;Chacko et al, 2012;Moya-Ortega et al, 2012). Similar to other nanoparticulate DDS, nanogels can easily be administered in liquid form for parenteral drug delivery.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…The nanoscale size of nanogels gives them a high specific surface area that is available for further bioconjugation of active targeting agents and macromolecules. Drug release properties, biodistribution and excretion can be modulated through size adjustments, too (Vinogradov, 2007;Kabanov & Vinogradov, 2009;Sasaki & Akiyoshi, 2010;Chacko et al, 2012;Moya-Ortega et al, 2012).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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“…30 nm) in solution [10][11][12]. CHP nanogels are self-assembled physical gels in which hydrophobic cholesteryl groups provide physical cross-linking points [13]. One advantage of nanogels is that they can form a colloidally stable complex with a protein with an overall complex size of about 50 nm, which is suitable for effective intracellular uptake.…”

Section: Introductionmentioning

confidence: 99%

“…Hybrid organic-inorganic materials have many advantages because of their broad physical and chemical properties, which have led to innovative uses in diverse fields including optics, electronics, health care, energy and the environment [1][2][3]. One of the most important inorganic compounds is hydroxyapatite [HAp, Ca 10 (PO 4 ) 6 (OH) 2 ], which is a major mineral component of natural bone and teeth.…”

Section: Introductionmentioning

confidence: 99%

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

et al. 2012

Self Cite

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Nanosized hydroxyapatite (HAp) materials have received much attention in the context of their advanced biomedical applications, including tissue engineering and drug delivery systems. Hybridization of nanosized HAp with organic molecules is a promising approach to facilitate the preparation of HAp nanomaterials. Here, templated mineralization using self-assembled nanogels modified with tricarboxylate groups was performed to yield the hybrid HAp nanomaterial. In the pH gradient method, the nanogel acted as an excellent template for the formation of well-dispersed HAp particles. Transmission electron microscopy, selected area electron diffraction patterns and energy-dispersive X-ray spectroscopy of these particles revealed that amorphous nanoparticles of amorphous calcium phosphate formed first, followed by transformation to crystalline hydroxyapatite. OPEN ACCESSPolymers 2012, 4 1057

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Nanogel engineering for new nanobiomaterials: from chaperoning engineering to biomedical applications

Cited by 338 publications

References 82 publications

Folic acid-targeted disulfide-based cross-linking micelle for enhanced drug encapsulation stability and site-specific drug delivery against tumors

Folic acid-targeted disulfide-based cross-linking micelle for enhanced drug encapsulation stability and site-specific drug delivery against tumors

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

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