Nanog, as a key cancer stem cell marker in tumor progression

Vasefifar, Parisa; Azad, Rohollah Motafakker; Maleki, Leili Aghebati; Najafi, Souzan; Ghrobaninezhad, Farid; Najafzadeh, Basira; Alemohammad, Hajar; Baghbanzadeh, Amir; Baradaran, Behzad

doi:10.1016/j.gene.2022.146448

Cited by 46 publications

(21 citation statements)

References 132 publications

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“…Gastric cancer stemness can be determined by investigating the expression of cell surface markers, namely CD24, CD44, and LGR5, and stemness-related transcriptional factors, namely Nanog and SOX2. Nanog is widely expressed in human cancer and is involved in self-renewal, metastasis, and chemoresistance [ 33 , 34 ]. SOX2 is involved in the maintenance of an undifferentiated cellular phenotype and often leads to increased chemotherapy resistance in cancer [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation

et al. 2022

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Chemotherapy is the treatment of choice for gastric cancer; however, the currently available therapeutic drugs for treatment have limited efficacy. Cancer stemness and the tumor microenvironment may play crucial roles in tumor growth and chemoresistance. Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum chaperone facilitating protein folding and cell homeostasis during stress and may participate in chemoresistance. Isoliquiritigenin (ISL) is a bioactive flavonoid found in licorice. In this study, we demonstrated the role of GRP78 in gastric cancer stemness and evaluated GRP78-mediated stemness inhibition, tumor microenvironment regulation, and chemosensitivity promotion by ISL. ISL not only suppressed GRP78-mediated gastric cancer stem cell–like characteristics, stemness-related protein expression, and cancer-associated fibroblast activation but also gastric tumor growth in xenograft animal studies. The findings indicated that ISL is a promising candidate for clinical use in combination chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation

et al. 2022

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“…Cancer cells are not able to develop in certain body without the presence of stem cells. They first attack on stem cells and handle all their activities and by using single cell they start making tumor in the body [11]. The major cause of skin ovary cancer is still understudy because most of studies are going on this issue to calculate the exact reason of developing these tumors.…”

Section: Discussionmentioning

confidence: 99%

A Study of Cancer of Ovaries among Women and it’s Linked with the Stem Cells present in Body: A Review

John¹,

Anthony²,

Bhatti³

2022

PJMHS

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Background: Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world. A woman’s lifetime risk of developing OC is 1 in 75, and her chance of dying of the disease is 1 in 100.Cells which initiate cancer cells in the body are somehow known as stem cells. Objective: The objective of this review was to evaluate the published literature on epidemiologic risk factors for ovarian cancer among women and it’s linked with the stem cells present in the body. Material and methods: A review of literature search was conducted in PubMed and Scopus. Studies comparing ovarian cancer among women and its linked with the stem cells present in the body were included. Results: Eight of 94 articles met the inclusion criteria. The articles revealed that there are no rules to separate out the cells which are spreading tumor cells or in short from this research they said that we are not able to separate them out but we can clarify the issue that either they are spreading this deadly disease or not. Stem cells are not linked with ovarian cancer. Conclusion: It is concluded that phonetically both cancer cells and stem cells are not same. They are showing their opposite impacts. In this study we have seen that first they initiate from a single cell and then start replicating and make groups. There are many other ways through which tumor cells can generate themselves so it is not easy to say that they are growing from stem cells. Keywords: Ovarian cancer, Stem cells and Women

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“…Some of these proteins, including OCT4, MYC, KLF4, and SOX2 (Yamanaka factors), are universal, considering that they are typical of both cancer and normal stem cells and are considered essential for stem-related phenotypes [ 107 ]. The regulation of other markers, though, for instance, NANOG, BMI-1, SNAIL, ALDHs, LGR5, CXCR4, REX-1, Musashi-1, LETM1, and C-met, is considered to be dependent on both the cancer type and the specific phenotype of the CSCs that we want to analyze (e.g., drug-resistant, tumorigenic, metastatic) [ 35 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ]. Studying the expression of specific genes both at the transcriptional and translation level, as well as the activity and localization of these proteins, is useful in assessing the enrichment of CSC properties [ 118 , 119 , 120 , 121 , 122 , 123 ].…”

Section: Cancer Stem Cells (Cscs)mentioning

confidence: 99%

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression

Tsochantaridis

Roupas

Mohlin

et al. 2023

Life

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Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity, which obstructs the efficient eradication of the tumor. Tumor heterogeneity is often associated with the presence of cancer stem cells (CSCs), a cancer cell sub-population possessing a panel of stem-like properties, such as a self-renewal ability and multipotency potential. CSCs are associated with enhanced chemoresistance due to the enhanced efflux of chemotherapeutic agents and the existence of powerful antioxidant and DNA damage repair mechanisms. The distinctive characteristics of CSCs make them ideal targets for clinical therapeutic approaches, and the identification of efficient and specific CSCs biomarkers is of utmost importance. Aldehyde dehydrogenases (ALDHs) comprise a wide superfamily of metabolic enzymes that, over the last years, have gained increasing attention due to their association with stem-related features in a wide panel of hematopoietic malignancies and solid cancers. Aldehyde dehydrogenase 1B1 (ALDH1B1) is an isoform that has been characterized as a marker of colon cancer progression, while various studies suggest its importance in additional malignancies. Here, we review the basic concepts related to CSCs and discuss the potential role of ALDH1B1 in cancer development and its contribution to the CSC phenotype.

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Nanog, as a key cancer stem cell marker in tumor progression

Cited by 46 publications

References 132 publications

Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation

Isoliquiritigenin Inhibits Gastric Cancer Stemness, Modulates Tumor Microenvironment, and Suppresses Tumor Growth through Glucose-Regulated Protein 78 Downregulation

A Study of Cancer of Ovaries among Women and it’s Linked with the Stem Cells present in Body: A Review

The Concept of Cancer Stem Cells: Elaborating on ALDH1B1 as an Emerging Marker of Cancer Progression

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