Nanoformulation of antiretroviral drugs enhances their penetration across the blood brain barrier in mice

Fiandra, Luisa; Colombo, Miriam; Mazzucchelli, Serena; Truffi, Marta; Santini, Benedetta; Allevi, Raffaele; Nebuloni, Manuela; Capetti, Amedeo; Rizzardini, Giuliano; Prosperi, Davide; Corsi, Fabio

doi:10.1016/j.nano.2015.03.009

Cited by 57 publications

(37 citation statements)

References 30 publications

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“…SPIONs coated with the bilayer resulted in an increased drug loading capacity (2.8 fold for tenofovir) and drug release (30 fold with 100% release) over a period of 5 days. Use of SPIONs to cross the blood brain barrier (BBB) has been shown by Fiandra et al [47]. A structurally complex drug enfuvitride, which normally is unable to cross the BBB, was able to cross the same when tagged onto SPIONs and coated with PMA amphiphilic polymer.…”

Section: 1 Studies On Hivmentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

152

111

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Nanotechnology is increasingly playing important roles in various fields including virology. The emerging use of metal or metal oxide nanoparticles in virus targeting formulations shows the promise of improved diagnostic or therapeutic ability of the agents while uniquely enhancing the prospects of targeted drug delivery. Although a number of nanoparticles varying in composition, size, shape, and surface properties have been approved for human use, the candidates being tested or approved for clinical diagnosis and treatment of viral infections are relatively less in number. Challenges remain in this domain due to a lack of essential knowledge regarding the in vivo comportment of nanoparticles during viral infections. This review provides a broad overview of recent advances in diagnostic, prophylactic and therapeutic applications of metal and metal oxide nanoparticles in Human Immunodeficiency Virus, Hepatitis virus, influenza virus and Herpes virus infections. Types of nanoparticles commonly used and their broad applications have been explained in this review.

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Section: 1 Studies On Hivmentioning

confidence: 99%

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Yadavalli

Shukla

2017

Nanomedicine: Nanotechnology, Biology and Medicine

152

111

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“…Recent years have seen advancements in the development of promising nanotechnologies for delivery of antiretroviral drugs to the CNS [26]. Notably, amphiphilic polymer coated iron oxide nanoparticles synthesized by solvothermal methods and functionalized with the antiretroviral peptide enfuvirtide were shown to facilitate drug carriage across the BBB [27]. The mechanism of nanoparticle transport across the endothelial barrier was investigated using both in vitro and in vivo models demonstrating intracellular distribution of enfuvirtide-modified iron oxide nanoparticles.…”

Section: Sustained-release Arv Formulationsmentioning

confidence: 99%

“…Indeed, cell-based nanocarriers have been developed for not only cancer chemotherapy but also a wide range of microbial infections [49, 51, 52]. Cell targeted nanomedicines may offer several advantages over conventional drug delivery methods including enhanced efficacy, reduced side effects, increased drug stability and effective subcellular targeting [27, 53, 54]. To facilitate macrophage targeting, our laboratory developed injectable ART nanoformulations and evaluated drug delivery to macrophage subcellular compartments and tissues, as well as the pharmacokinetic profile [28, 29, 30, 53, 54, 55, 56, 57].…”

Section: Targeted Deliverymentioning

confidence: 99%

Long-acting slow effective release antiretroviral therapy

Edagwa

McMillan

Sillman

et al. 2017

Expert Opinion on Drug Delivery

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Introduction Advances in the development of long acting antiretroviral therapy (ART) can revolutionize current treatments for HIV/AIDS. We have coined the term long active slow effective release ART (LASER ART) based on properties of slow drug dissolution, poor water-solubility, excellent bioavailability, limited off target systemic toxicities, and excellent patient treatment adherence. Drug carrier technologies characterized by high payload of antiretroviral drugs (ARVs) in a single carrier are being developed to improve the pharmacokinetics and pharmacodynamics of the nanoformulated ART (nanoART). Additionally, surface modification of slow release antiretroviral carriers with targeting ligands has facilitated receptor-mediated transport across physiological barriers serves to improve therapeutic outcomes. Areas covered This review highlights current developments of reservoir targeted LASER ART delivery platforms that have the potential to improve HIV/AIDS therapeutic outcomes. Such nanoART delivery platforms include decorated multifunctional nano- and micro- particles, prodrugs and polymer conjugates. Therapeutic strategies such as anti-inflammatory and neuroprotective agents and CRISPR/Cas 9 based gene-editing technologies that affect drug depots, boost ART effectiveness and facilitate viral clearance are discussed. Expert opinion The persistence of HIV-1 in its lymphoid, gut and nervous system reservoirs poses a major challenge to viral eradication. Emerging innovative strategies for effective medicines and slow release products to target intracellular pathogens, immune based interventions, genome-editing technologies, compounds that sustain drug depots and combinations of nanoART and image contrast agents have the potential to meet the unmet clinical needs of HIV patients. Such efforts will bring the medicines to sites of active viral replication and accelerate viral clearance.

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“…Recently, Fiandra et al investigated amphiphilic polymer (MYTS) to improve the permeation of a high-weighted ARV drug [Enfuvirtide-Enf)] across the BBB both in in-vitro and in-vivo models. Results showed good efficacy and trans-BBB permeation of nanoformulation across BBB in mice model [100]. The advantage of MYTS coating on nanoparticles is that it help in loading of multiple drugs of different classes.…”

Section: Introductionmentioning

confidence: 99%

Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS

Nair

Jayant

Kaushik

et al. 2016

Advanced Drug Delivery Reviews

154

121

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In spite of significant advances in anti-retroviral (ARV) therapy, the elimination of human immunodeficiency virus (HIV) reservoirs from the periphery and the CNS remains a formidable task. The incapability of ARV to go across the blood-brain-barrier (BBB) after systemic administration makes the brain one of the dominant HIV reservoirs. Thus, screening, monitoring, and elimination of HIV reservoirs from the brain remain a clinically daunting and key task. The practice and investigation of nanomedicine possesses potentials for therapeutics against neuroAIDS. This review highlights the advancements in nanoscience and nanotechnology to design and develop specific sized therapeutic cargo for efficient navigation across BBB so as to recognize and eradicate HIV brain reservoirs. Different navigation and drug release strategies, their biocompatibility and efficacy with related challenges and future prospects are also discussed. This review would be an excellent platform to understand nano-enable multidisciplinary research to formulate efficient nanomedicine for the management of neuroAIDS.

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Nanoformulation of antiretroviral drugs enhances their penetration across the blood brain barrier in mice

Abstract: 12Eradication of virus by sanctuary sites is a main goal in HIV management. The central nervous system (CNS) is a classic model of

Cited by 57 publications

References 30 publications

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections

Long-acting slow effective release antiretroviral therapy

Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS

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