Nanofluidic Devices and Applications for Biological Analyses

Yamamoto, Koki; Ota, Noriyasu; Tanaka, Yo

doi:10.1021/acs.analchem.0c03868

Cited by 44 publications

(43 citation statements)

References 151 publications

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“…Microfluidic techniques based on a single type of manipulation force have shown remarkable progress. [203][204][205] However, for real-world complex and heterogeneous samples, a single manipulation force type or single processing step cannot always meet the separation needs. Therefore, a combination of two or more manipulation techniques is emerging as a promising approach.…”

Section: A Comparison Of Manipulating Forcesmentioning

confidence: 99%

Multiphysics microfluidics for cell manipulation and separation: a review

et al. 2022

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Section: A Comparison Of Manipulating Forcesmentioning

confidence: 99%

Multiphysics microfluidics for cell manipulation and separation: a review

et al. 2022

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“…Microfluidics is the development and study of devices and systems with operational dimensions in the 1-100 µm range for the manipulation of small (10 −9 -10 −18 L) quantities of fluids [26]. As technological progress in microfluidics [27] has continued over the past 20 years, the use of analyzing patient biofluids (e.g., blood, urine, or saliva) containing particles sized from 10 nm to 100 µm as a diagnostic tool for cancer has also found major interest [28][29][30]. Microfluidic devices have been extensively used for the isolation, enrichment, and detection of large biomolecules like DNA [31] and proteins [32], as well as extracellular vesicles [33], circulating tumor cells (CTCs) [34], and circulating nucleic acids [35].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Approaches and Methods Enabling Extracellular Vesicle Isolation for Cancer Diagnostics

et al. 2022

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Advances in cancer research over the past half-century have clearly determined the molecular origins of the disease. Central to the use of molecular signatures for continued progress, including rapid, reliable, and early diagnosis is the use of biomarkers. Specifically, extracellular vesicles as biomarker cargo holders have generated significant interest. However, the isolation, purification, and subsequent analysis of these extracellular vesicles remain a challenge. Technological advances driven by microfluidics-enabled devices have made the challenges for isolation of extracellular vesicles an emerging area of research with significant possibilities for use in clinical settings enabling point-of-care diagnostics for cancer. In this article, we present a tutorial review of the existing microfluidic technologies for cancer diagnostics with a focus on extracellular vesicle isolation methods.

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“…In addition, droplet handling can only be applied to simple processes like mixing, and complicated processes such as sampling and phase separation are difficult to perform. On the other hand, nanofluidic devices [30][31][32][33] have a size of 10-1000 nm and the nanospace has a femtoliter to picoliter (fL-pL) volume. Thus, nanofluidic devices have been expected as a suitable tool for chemically processing individual molecules.…”

Section: Introductionmentioning

confidence: 99%