Nanofiltration-based diafiltration process for solvent exchange in pharmaceutical manufacturing

Sheth, Jignesh P.; Qin, Yingjie; Sirkar, Kamalesh K.; Baltzis, Basil C.

doi:10.1016/s0376-7388(02)00423-4

Cited by 112 publications

(48 citation statements)

References 7 publications

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“…A multiple membrane passage may improve the overall rejection but not the separation between different individual compounds. Diafiltration is sometimes a good solution when product recovery is considered, such as in solvent exchange [115], but is not applicable for separation of individual solutes. The use of continuous counter current integrated membrane cascades with recycle, in analogy with (conventional) separations based on thermodynamic equilibrium (presented in Fig.…”

Section: Insufficient Separationmentioning

confidence: 99%

Drawbacks of applying nanofiltration and how to avoid them: A review

Bruggen

Mänttäri

Nyström

2008

Separation and Purification Technology

739

293

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Section: Insufficient Separationmentioning

confidence: 99%

Drawbacks of applying nanofiltration and how to avoid them: A review

Bruggen

Mänttäri

Nyström

2008

Separation and Purification Technology

739

293

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“…124,[161][162][163][164] Most recently, the separation and purification of active molecules in organic medium by NF membranes (called SRNF membranes) has attracted significant attention because unlike conventional distillation, this process is athermal. The SRNF membranes can potentially be used in the pharmaceutical manufacturing industry, [165][166][167][168][169][170][171][172][198][199][200] catalysis recovery processes, [173][174][175][176][177][178][179][180][181][182][183]196,197 the concentration of biologically active compounds in food technology, 192 the recovery of ion liquids, [184][185][186] the purification of fuels and solvents, 188,189 refining technologies, 187 and many other fields. 205 All of these fields have a common feature: the cost and the energy consumption to prepare or recover active molecules are very high, which makes the application of SRNF economically attractive.…”

Section: Advanced Applications Of Srnf Membranesmentioning

confidence: 99%

“…Sheth et al 165 claimed that precompacting commercial MPF-50 or MPF-60 with used solvents at operational pressures and temperatures is necessary to remove erythromycin because precompaction increased the rejection of erythromycin by SRNF membranes, which reduced the loss of erythromycin and increased the purification efficiency. Shi et al 166 fabricated a type of PI membrane to concentrate spiramycin 220 (n-alkanes in toluene) [168][169][170][171][173][174][175]180,182,184,[190][191][192]195,197 Starmem TM 228 280 (n-alkanes in toluene) 169,179,184,196 Starmem TM 240 400 (n-alkanes in toluene) [171][172][173][174][175]180,182,184,185,189,196,197 Puramem TM extracts and recover the used solvent (butyl acetate).…”

Section: Pharmaceutical Applicationsmentioning

confidence: 99%

Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes

et al. 2014

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When considering energy consumption and environmental issues, solvent-resistant nanofiltration (SRNF) based on polymeric materials emerges as a process for substituting conventional separation processes of organic solutions, such as distillation, which consume high amounts of energy. Because SRNF does not involve phase transition, this process can potentially decrease the energy consumption and solvent waste and increase the yield of active components. Such improvements could significantly benefit a number of fields, such as pharmaceutical manufacturing and catalysis recovery, among others. Therefore, SRNF has gained a lot of attention since the recent introduction of solvent-stable polymeric materials in the manufacture of nanofiltration membranes. The membrane materials and the membrane structures depending on the fabrication methods determine the separation performance of polymeric SRNF membranes. Therefore, this article gives a comprehensive overview of the current state-of-art technologies of generating membrane materials and corresponding fabrication methods for SRNF membranes made from polymeric materials expected to provide the most benefit. The transport mechanisms and the corresponding models of SRNF membranes in organic media are also reviewed to better understand the mass transfer process. Various SRNF applications, such as in pharmaceutical and catalyst, among others, are also discussed. Finally, the difficulties and future research directions to overcome the challenges faced by SRNF processes are proposed. C

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“…Some examples for application of OSN to concentration and purification in industrial applications have been published previously. For instance, OSN was applied to the recovery and purification of pharmaceuticals [Cao et al, 2001;Marchetti et al, 2013;Sun et al, 2014], solvent exchange [Sheth et al, 2003], separation of base chemicals [Werhan et al, 2012;Othman et al, 2010], purification and concentration of consumer chemicals [Vanneste et al, 2011;Tsibranska and Tylkowski, 2013], concentration and purification of specialty chemicals [Tsui and Cheryan, 2007], and homogeneous catalyst recycle [Van der Gryp et al, 2010]. These studies showed the feasibility of OSN technologies in different industries at laboratory scale with flat sheet membranes or with 1.8"x12" spiral-wound membrane modules.…”

Section: Introductionmentioning

confidence: 99%

Multi-scale modelling of OSN batch concentration with spiral-wound membrane modules using OSN Designer

Shi

Peshev

Marchetti

et al. 2016

Chemical Engineering Research and Design

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Three commercial spiral-wound membrane modules of different sizes, from 1.8"x12" to 4.0"x40", are used to concentrate a solution of sucrose octaacetate in ethyl acetate under different operating conditions. A mathematical model to describe the batch concentration process is developed, based on a combination of the classical solution diffusion membrane transport model and the film theory, to account for the mass transfer effects. The model was implemented using the "OSN Designer" software tool. The membrane transport model parameters as well as all parameters in the pressure drop and mass transfer correlations for the spiral-wound modules were obtained from regression on a limited number of experimental data at steady state conditions. Excellent agreement was found between the experimental and multi-scale modelling performance data under various operating conditions. The results illustrate that the performance of a large scale batch concentration process with spiral-wound membrane modules can be predicted based on laboratory crossflow flat sheet test data when the fluid dynamics and mass transfer characteristics in the module, and the necessary channel geometry are known. In addition, the effects of concentration polarisation, pressure drop through feed and permeate channels, and thermodynamic non-ideality of the solution at large scale batch concentration are also investigated.2

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Nanofiltration-based diafiltration process for solvent exchange in pharmaceutical manufacturing

Cited by 112 publications

References 7 publications

Drawbacks of applying nanofiltration and how to avoid them: A review

Drawbacks of applying nanofiltration and how to avoid them: A review

Recent Advances in Polymeric Solvent‐Resistant Nanofiltration Membranes

Multi-scale modelling of OSN batch concentration with spiral-wound membrane modules using OSN Designer

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