Nanofibrous Scaffolds with Biomimetic Composition for Skin Regeneration

Khalili, Shahla; Khorasani, Saied Nouri; Razavi, Seyed Mohammad Javad; Hashemibeni, Batool; Tamayol, Ali

doi:10.1007/s12010-018-2871-7

Cited by 47 publications

(42 citation statements)

References 29 publications

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“…The blend ratio has been reported to have a significant effect on the morphology, surface area, crystallinity, thermal properties, miscibility, surface hydrophilicity, and cell culture. Furthermore, ternary blend scaffolds have also been fabricated for skin regeneration applications with gelatine, cellulose acetate, and elastin [192]. The use of micro-and nanocellulose in ternary or multicomponent biopolymer blends for scaffold fabrication has enhanced the functional properties of scaffolds.…”

Section: Micro-and Nanocellulose-based Ternary Blends Scaffoldmentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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Biopolymers have been used as a replacement material for synthetic polymers in scaffold forming due to its biocompatibility and nontoxic properties. Production of scaffold for tissue repair is a major part of tissue engineering. Tissue engineering techniques for scaffold forming with cellulose-based material is at the forefront of present-day research. Micro- and nanocellulose-based materials are at the forefront of scientific development in the areas of biomedical engineering. Cellulose in scaffold forming has attracted a lot of attention because of its availability and toxicity properties. The discovery of nanocellulose has further improved the usability of cellulose as a reinforcement in biopolymers intended for scaffold fabrication. Its unique physical, chemical, mechanical, and biological properties offer some important advantages over synthetic polymer materials. This review presents a critical overview of micro- and nanoscale cellulose-based materials used for scaffold preparation. It also analyses the relationship between the method of fabrication and properties of the fabricated scaffold. The review concludes with future potential research on cellulose micro- and nano-based scaffolds. The review provides an up-to-date summary of the status and future prospective applications of micro- and nanocellulose-based scaffolds for tissue engineering.

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Section: Micro-and Nanocellulose-based Ternary Blends Scaffoldmentioning

confidence: 99%

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

et al. 2020

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“…The presence of elastin in composite electrospun nanofibrous scaffolds, containing gelatin, cellulose acetate and elastin, changed the fiber morphology from straight to ribbon-like structure, and decreased the swelling ratio and degradation rate of the scaffolds. In addition, elastin-containing scaffolds supported the attachment and proliferation of human fibroblasts [119].…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 99%

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Bačáková¹,

Pajorová²,

Zikmundová³

et al. 2020

Current and Future Aspects of Nanomedicine

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Nanofibrous scaffolds belong to the most suitable materials for tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. This chapter is focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is the largest and vitally important organ in the human body. Nanofibrous meshes can serve as substrates for adhesion, growth and differentiation of skin and stem cells, and also as an antimicrobial and moistureretaining barrier. These meshes have been prepared from a wide range of synthetic and nature-derived polymers. This chapter is focused on the use of nature-derived polymers. These polymers have good or limited degradability in the human tissues, which depends on their origin and on the presence of appropriate enzymes in the human tissues. Non-degradable and less-degradable polymers are usually produced in bacteria, fungi, algae, plants or insects, and include, for example, cellulose, dextran, pullulan, alginate, pectin and silk fibroin. Well-degradable polymers are usually components of the extracellular matrix in the human body or at least in other verte brates, and include collagen, elastin, keratin and hyaluronic acid, although some polymers produced by non-vertebrate organisms, such as chitosan or poly(3-hydroxybutyrate-co-3-hydroxyvalerate), are also degradable in the human body.Current and Future Aspects of Nanomedicine 2 microbial infection, and at the same time, they can keep appropriate moisture and gas exchange at the wound site.Nanofibrous scaffolds for skin tissue engineering have been fabricated from a wide range of synthetic and nature-derived polymers, which can be either biostable or degradable within the human body. Biostable synthetic polymers used in nanofiber-based skin regenerative therapies include, for example, polyurethane [2], polydimethylsiloxane [3], polyethylene terephthalate [4], polyethersulfone [5], and also hydrogels such as poly(acrylic acid) (PAA, [6]), poly(methyl methacrylate) (PMMA, [7]), and poly[di(ethylene glycol) methyl ether methacrylate] (PDEGMA, [8]). Degradable synthetic polymers typically include poly(ε-caprolactone) (PCL, [9]) and its copolymers with polylactides (PLCL, [10]), polylactides (PLA, [11]) and their copolymers with polyglycolides (PLGA, [12]), and also so-called auxiliary polymers, such as poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO, [13]) or poly(vinyl alcohol) (PVA, [14]), which facilitated the electrospinning process and improved the mechanical properties and wettability of the chief polymer. However, the synthetic polymers, although they are well-chemically defined and tailorable, are often bioinert, hydrophobic and thus not promoting cell adhesion, and also not well-adhering to the wound site. Therefore, they need to be combined with other bioactive substances, particularly nature-derived polymers.This chapter is focused on nature-derived polymers used for fabrication of nanofibrous scaffolds for skin tissue engineering and wound healing. The advantages of...

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“…Skin as the largest and the outermost organ of the body protects us from many biological and nonbiological invasions. However, it can be breached easily when a skin region is injured as a result of surgery, trauma, burn, radiation, and deep cuts . The situation becomes more complicated and costly to ameliorate in case of chronic wounds, which are normally categorized as venous leg ulcers, bedsores, and diabetic foot ulcers .…”

Section: Introductionmentioning

confidence: 99%

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Ansarizadeh

Haddadi

Amini

et al. 2020

J of Applied Polymer Sci

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Electrospinning is an economical and alluring method to fabricate wound dressing mats from a variety of natural and synthetic materials. In this study, polyvinylidene fluoride (PVDF) and starch composite mats containing ciprofloxacin (CIP) loaded on titanium dioxide nanoparticles (TiO 2 ) were prepared. Fourier Transform Infrared spectra of CIP, synthesized TiO 2 NPs, TiO 2 /CIP, and PVDF/starch composite mats are analyzed. Scanning electron microscopy images revealed that the fiber diameter of PVDF nanofibers thickens by increasing starch, which varies between 180 nm and 550 nm. Strain at break of PVDF, starch, PVDF/starch (2:1 w:w; P2S1), PVDF/starch (1:1 w:w; P1S1), PVDF/starch (1:2 w:w; P1S2), and nanofibers were 103 AE 11, 3 AE 0.6, 27 AE 4, 52 AE 5.2, 7.7 AE 1%, respectively. Based on strain at break and young modulus, P2S1 was selected as a suitable candidate for wound dressing to which load TiO 2 / CIP as a bioactive agent. The release rate of CIP showed that about 40% of the drug is released in the first 2 days. Furthermore, the antibacterial activity of dressings was investigated using Escherichia coli and Staphylococcus aureus microorganisms and zones of clearance were obvious around the specimen on the agar plate.

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Nanofibrous Scaffolds with Biomimetic Composition for Skin Regeneration

Cited by 47 publications

References 29 publications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

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Nanofibrous Scaffolds with Biomimetic Composition for Skin Regeneration

Cited by 47 publications

References 29 publications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

A Review on Micro- to Nanocellulose Biopolymer Scaffold Forming for Tissue Engineering Applications

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Sustained release of CIP from TiO2‐PVDF/starch nanocomposite mats with potential application in wound dressing

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Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing