Nanofibrous membranes as smart wound dressings that release antibiotics when an injury is infected

Rivero, Guadalupe; Meuter, M.; Pepe, Alfonso; Guevara, María Gabriela; Boccaccını, Aldo R.; Abraham, Gustavo Abel

doi:10.1016/j.colsurfa.2019.124313

Cited by 43 publications

(22 citation statements)

References 14 publications

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“…Glucuronoxylan (GX) has been used due to its pH-responsive swelling properties upon shifting of the pH from acidic to neutral [188]. This was intended to follow the natural wound pH variation from acidic to slightly alkaline during the different phases of wound healing, due to the imbalance between tissue remodeling and degradation processes [189]. Another antibiotic, fluconazole, has been successfully incorporated into GX hydrogels for drug delivery applications [188].…”

Section: Smart Nanomaterialsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

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Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers, scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

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Section: Smart Nanomaterialsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

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“…Under this background, many compounds with antibacterial activity have been widely studied, such as CS, a natural substance with antibacterial activity, 71,72 the antibacterial drug ketoprofen, 73 and antibiotics. 74,75 Ranjith et al 72 reviewed the latest research progress of CS nanober wound dressings, and systematically introduced the latest research on CS-based nanober membrane-loading therapeutic agents (e.g., curcumin, asiaticoside, ferulic acid, tannic acid). It involved a variety of compounds with antibacterial activity from natural plants.…”

Section: Wound Dressingmentioning

confidence: 99%

Application of blocking and immobilization of electrospun fiber in the biomedical field

Ning

Shen

2020

RSC Adv.

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“…Glucuronoxylan (GX) has been used due to its pH-responsive swelling properties upon shifting of the pH from acidic to neutral [159]. This was intended to follow the natural wound pH variation from acidic to slightly alkaline during the different phases of wound healing, due to the imbalance between tissue remodelling and degradation processes [160]. Another antibiotic, fluconazole has been successfully incorporated into GX hydrogels for drug delivery applications [159].…”

Section: Smart Nanomaterialsmentioning

confidence: 99%

“…Nanofibrous electrospun membranes were prepared by loading an antibiotic, such as nitrofurazone, into Eudragit® S100 (ES 100) polymer solution as potential smart nanomaterial for skin infection treatment. ES100 is a pH-responsive polymer that dissolves at pH higher than 7, thus triggering the release of the antibacterial agent [160].…”

Section: Smart Nanomaterialsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Patrulea¹,

Borchard²,

Jordan³

2020

Preprint

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Bacterial infections occur when wound healing fails to reach the final stage of healing, usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site accompanied very often by an increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies, such as polymers, scaffolds, films and wound dressings, organic and inorganic nanoparticles, to combat infection and modulate the healing rate have been discussed as well. New technologies such as CRISPR-Cas are taken into consideration as potential future tools for AMP delivery in skin therapy.

show abstract

Nanofibrous membranes as smart wound dressings that release antibiotics when an injury is infected

Cited by 43 publications

References 14 publications

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Application of blocking and immobilization of electrospun fiber in the biomedical field

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

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