Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Abstract

In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1-2 µm, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds' antimicrobial properties were evaluated against S. aureus and E. faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotic's total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria.

The synthesis of amino-functionalized carbon quantum dots-decorated hydroxyapatite as drug delivery agent

“…The formation of agglomerated nano-HAp can be commonly found when the particles are synthesized by using water as solvent [19]. The Ca/P ratio for the samples is in the range of 1.49 to 1.64, which is near to stoichiometric HAp [19,20] and close to the results shown in XPS analysis. Both infrared and XRD analyses confirm the formation of HAp by showing similar spectra for all samples.…”

Recent Advances and Outlook in Nanotechnology

“…A careful study of the result of the average pore size of scaffolds on the rate of diffusion flow of nutrients through it at 12 rpm indicates that the pores do not significantly affect the rate of nutrient spread. Such conduct at identical parameters is confirmed in empirical works [12] and perhaps denotes the preference of optimal scaffold rotation rate.…”