The synthesis of amino-functionalized carbon quantum dots-decorated hydroxyapatite as drug delivery agent

Abstract

Hydroxyapatite (HAp) was combined with amino-functionalized carbon quantum dots (CQDs) to enhance the optical and surface area properties of HAp. The loading of aminofunctionalized CQDs could enhance the luminescence of HAp and its UV-Vis absorbance. Additionally, surface area of HAp could be increased from 84.16 to 129.94 m 2 /g by loading aminofunctionalized CQDs. The drug release experiment was conducted using acetaminophen. The release happened slowly for amino-functionalized CQDs/HAp, with full release of acetaminophen being observed after 24 h. The enhanced luminescence composite shows high potential for the composite to be used for the controlled release of drugs.

Hydroxyapatite-based carriers for tumor targeting therapy

“…In addition, the surface area of HAP can increase from 84.16 m 2 g −1 to 129.94 m 2 g −1 , which is beneficial for drug loading. 89 The study on the synthesis of Mg-HAP samples using the reflux condensation method found that as the concentration of Mg increased, the recombination of charge carriers was blocked, and the photoluminescence intensity increased. 90 The self-luminescent property of Mg-HAP particles, which is because of their surface plasmon, can be used in imaging and drug delivery applications.…”