Nanofibres: New scalable technology platform for producing polymeric nanofibres

Gangwal, Sumit; Wright, Miles

doi:10.1016/s0015-1882(13)70077-6

Cited by 12 publications

(10 citation statements)

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“…Within these nanomaterials, it is possible to find nanofibers, nanotubes, nanorods, and nanowires, which have been researched due to their special physical and chemical properties [ 3 ]. Specifically, the nanofibers are characterized by offering unique physical, mechanical, and electrical properties associated with their very high surface area, light weight, and small pores [ 4 ]. These nanofibers can be produced by many methods, such as vapor-phase methods, solution-liquid-solid methods, template-directed methods, and self-assembly and hydrothermal synthesis methods [ 3 ], but compared to these above methods, electrospinning is characterized as a remarkably simple, low-cost, and environment-friendly technique.…”

Section: Introductionmentioning

confidence: 99%

Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats

et al. 2018

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The main objective of this work was to study the release of cinnamaldehyde (CIN) from electrospun poly lactic acid (e-PLA) mats obtained through two techniques: (i) direct incorporation of active compound during the electrospinning process (e-PLA-CIN); and (ii) supercritical carbon dioxide (scCO2) impregnation of CIN within electrospun PLA mats (e-PLA/CINimp). The development and characterization of both of these active electrospun mats were investigated with the main purpose of modifying the release kinetic of this active compound. Morphological, structural, and thermal properties of these materials were also studied, and control mats e-PLA and e-PLACO2 were developed in order to understand the effect of electrospinning and scCO2 impregnation, respectively, on PLA properties. Both strategies of incorporation of this active compound into PLA matrix resulted in different morphologies that influenced chemical and physical properties of these composites and in different release kinetics of CIN. The electrospinning and scCO2 impregnation processes and the presence of CIN altered PLA thermal and structural properties when compared to an extruded PLA material. The incorporation of CIN through scCO2 impregnation resulted in higher release rate and lower diffusion coefficients when compared to active electrospun mats with CIN incorporated during the electrospinning process.

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Section: Introductionmentioning

confidence: 99%

Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats

et al. 2018

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“…95,96 However, with careful design, this can also lead to creation of defined lengths of polymeric nanofibers. 97,98 Harnessing this strength, Xanofi has created polymer filaments, which have tightly dispersed lengths and diameters ranging from 100 nm to 5 mm. 99…”

Section: Solution Spinningmentioning

confidence: 99%

Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases

Hotaling

Khristov

Wan

et al. 2016

Journal of Ocular Pharmacology and Therapeutics

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Clinical-grade manufacturing of a functional retinal pigment epithelium (RPE) monolayer requires reproducing, as closely as possible, the natural environment in which RPE grows. In vitro, this can be achieved by a tissue engineering approach, in which the RPE is grown on a nanofibrous biological or synthetic scaffold. Recent research has shown that nanofiber scaffolds perform better for cell growth and transplantability compared with their membrane counterparts and that the success of the scaffold in promoting cell growth/function is not heavily material dependent. With these strides, the field has advanced enough to begin to consider implementation of one, or a combination, of the tissue engineering strategies discussed herein. In this study, we review the current state of tissue engineering research for in vitro culture of RPE/scaffolds and the parameters for optimal scaffold design that have been uncovered during this research. Next, we discuss production methods and manufacturers that are capable of producing the nanofiber scaffolds in such a way that would be biologically, regulatory, clinically, and commercially viable. Then, a discussion of how the scaffolds could be characterized, both morphologically and mechanically, to develop a testing process that is viable for regulatory screening is performed. Finally, an example of a tissue-engineered RPE/scaffold construct is given to provide the reader a framework for understanding how these pieces could fit together to develop a tissue-engineered RPE/scaffold construct that could pass regulatory scrutiny and can be commercially successful.

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“…However, applications of nanofibers are still limited because of poor tensile properties, and lack of scale to satisfy the growing demand . Others have paid attention to develop new methods and equipment . A plethora of literature is available on the theoretical analysis of jet formation in electrospinning process .…”

Section: Introductionmentioning

confidence: 99%

Optimization of testing parameters for tensile property evaluation of poly(vinyl alcohol) nanofibers webs

Lou

Wang

Ramkumar

2018

J of Applied Polymer Sci

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An optimization study was conducted to understand the influence of thickness, speed of testing, and gauge length (specimen test length) on important mechanical properties of poly(vinyl alcohol) nanofiber webs. Using orthogonal experimental design, experimental trials were optimized for the three testing parameters, which enabled to undertake 25 experiments involving the three variables at five different levels. Polynomial regression equations show that the three variables have interactive influence on the mechanical properties tested. Of the three variables, thickness of nanofiber webs seems to have maximum influence on tensile properties. This study showed that the optimal values for tensile testing of nanowebs are gauge length at 0.50 cm, thickness of nanowebs at 0.10 mm, and speed of testing at 25 mmÁmin −1 . This study will provide an opportunity to establish a standard method for the tensile evaluation of nanowebs involving gauge length, thickness, and speed of testing.

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Nanofibres: New scalable technology platform for producing polymeric nanofibres

Cited by 12 publications

References 0 publications

Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats

Modifying an Active Compound’s Release Kinetic Using a Supercritical Impregnation Process to Incorporate an Active Agent into PLA Electrospun Mats

Nanofiber Scaffold-Based Tissue-Engineered Retinal Pigment Epithelium to Treat Degenerative Eye Diseases

Optimization of testing parameters for tensile property evaluation of poly(vinyl alcohol) nanofibers webs

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