Nanofibers Reinforced Polymer Composite Microstructures

Alubaidy, Andy; Venkatakrishnan, Krishnan; Tan, Bo

doi:10.5772/57101

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…One gramme of lead (II) chloride dissolves in 100 grammes of water at room temperature, but 200 grammes of zinc chloride dissolves in 100 grammes of water with the same concentrations of water . [4] Pressure: The solubility of gaseous solutes increases as pressure rises, while the solubility decreases as pressure falls.…”

Section: Classmentioning

confidence: 99%

“…Polymorphs will have varied solubility since the melting point of a solid is linked to solubility. [4] Techniques to Overcome Poor Solubility [7][8][9][10][11][12][13][14] Chemical Modifications:…”

Section: Classmentioning

confidence: 99%

“…Solubility can be described quantitatively as parts, molarity, normalcy, formality, mole fraction percent solution, volume fraction, and molality. Possible Causes for Poor Oral Absorption [4] any drug is said to be poorly soluble when:…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Techniques For Increasing Solubility: A Review Of Conventional And New Strategies

Yadav¹,

Sachan²,

Kumar³

et al. 2022

Asian J Pharm Res Dev

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Whenever a drug's success depends on its ability to disperse evenly in the liquid phase, solubility is a critical factor. Most active pharmacological compounds, on the other hand, are poorly soluble in water. The solubility of the medications is one of the most difficult parts of formulation creation. Due to a lack of water solubility, critical ingredients are left out of final medications, preventing them from reaching their full therapeutic potential. Due to poor water solubility, many novel medicines fail to launch in the market, despite their promising pharmacokinetic properties. Solubility in water limits the potential bioavailability of molecules that would otherwise have a significant impact on their physiological target. To achieve the desired (anticipat5ed) pharmacological response in the systemic circulation, aqueous solubility of a drug also affects the physical, chemical, dose stability, severs as a standard for purity, dissolution rate, rate and extent of absorption, and achieves the desired concentration of the drug in systemic circulation. When it comes to the formulation of medications, solubility is an extremely essential issue. A new API with high market demand must be developed by the formulation scientist if the molecule is to make it through the pharmaceutical development process. Solubilization techniques, such as chemical modification using solubilizers such as soluplus, povacoat, and dendrimers, as well as physical modification, complexation, and the use of surfactant, are being discussed in this review article because they are becoming increasingly important to the pharmaceutical industry by opening up new pathways for the preparation of effective and marketable drugs.

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Section: Classmentioning

confidence: 99%

Section: Classmentioning

confidence: 99%

See 1 more Smart Citation

Techniques For Increasing Solubility: A Review Of Conventional And New Strategies

Yadav¹,

Sachan²,

Kumar³

et al. 2022

Asian J Pharm Res Dev

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show abstract

“…Nanofibers are ultra-fine threads or filaments with diameters from a few nanometres to 1000 nm and a length that is not necessarily small but instead determined according to the manufacturer's purpose (Alubaidy et al 2013). Nanofibers can be categorized according to their size, which is determined by utilizing certain devices to measure diameter, length, or both, and based on morphology and construction, to form three types of structures: core-shell, hollow and porous nanofibers (Tolochko 2009;Khajavi and Abbasipour 2012).…”

Section: Nanofibersmentioning

confidence: 99%

Recent solubility and dissolution enhancement techniques for repaglinide a BCS class II drug: a review

Albetawi¹,

Abdalhafez²,

Abu‐Zaid³

et al. 2021

PHAR

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Repaglinide is an oral blood-glucose-lowering drug used to manage type-2 diabetes mellitus by lowering post-prandial glucose by stimulating insulin secretion from pancreatic beta cells. According to the biopharmaceutical classification system, repaglinide falls under the class II category. For such drugs, limited solubility and poor dissolution rate are the major hurdles to overcome by formulation scientists, as they hinder drug absorption and lead to inadequate therapeutic effects. Therefore, this review aims to discuss in depth the various approaches investigated in the past five years to improve the solubility and dissolution of orally administered repaglinide: namely, solid dispersion, co-amorphous technology, cyclodextrin complexation, phospholipid complexes and polymeric micelles, nanocrystals, nanosuspensions and nanofibers.

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“…fibers coupled with good fiber-matrix bonding offers exceptional properties due to the high fiber-matrix interface area [1]. One of the common techniques to produce nanofibers is electrospinning [2]- [6].…”

Section: Introductionmentioning

confidence: 99%

Processing and Characterization of PMMA Nanofiber Reinforced Epoxy Composites

Al-Assafi¹,

Bruijn²,

Al‐Jumaily³

2016

WJNSE

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Growing demand for high-performance materials is driving the development of composites with nano material reinforcement. The use of nano reinforcement can provide a distinct advantage due to high surface area of the material. There are still many challenges in achieving the full potential of nanocomposites. In this paper, we investigate the performance of epoxy nanocomposites reinforced with short polymethyl methacrylate (PMMA) nanofibers. PMMA nanofibers were chopped and mixed with the epoxy resin and then the mixture was poured into a mould. Samples were cut to an appropriate size after cure and mechanical testing was carried out. Tensile and flexural strength and modulus were evaluated for samples with various fiber volume fractions to determine changes in mechanical performance. Also Scanning Electron Microscopy was utilized to investigate fracture surface and fiber-matrix interface. Results indicated that mechanical performance dropped as volume fraction of fibers increased, namely poor fiber-matrix adhesion and presence of porosity resulted in deterioration in strength and modulus. Further research is required to develop fiber coating system to enhance performance of the nanocomposite by improving fiber-matrix adhesion and fiber wet-out.

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Nanofibers Reinforced Polymer Composite Microstructures

Cited by 7 publications

References 43 publications

Techniques For Increasing Solubility: A Review Of Conventional And New Strategies

Techniques For Increasing Solubility: A Review Of Conventional And New Strategies

Recent solubility and dissolution enhancement techniques for repaglinide a BCS class II drug: a review

Processing and Characterization of PMMA Nanofiber Reinforced Epoxy Composites

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