Nanofibers Offer Alternative Ways to the Treatment of Skin Infections

Heunis, Tiaan; Dicks, Leon M. T.

doi:10.1155/2010/510682

Cited by 79 publications

(51 citation statements)

References 105 publications

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“…1 Burn injury to the tissue caused by thermal energy is one of the most common casualties suffered by people worldwide. Millions of people suffer burn injuries and thousands die of the same each year.…”

Section: Introductionmentioning

confidence: 99%

Time Related Changes in Pathogenic Bacterial Patterns in Burn Wound Infections and Their Antibiotic Sensitivity Traits

Mehta

Singh²,

Sawhney

et al. 2017

Bangladesh J Med Sci

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Objectives: To examine the time related changes in the bacterial flora isolated from the burn patients and to compare the antibiograms of the predominant bacteria. Burn injuries constitute a major health concern with respect to morbidity and mortality as well as cost of management particularly in developing countries. It has been estimated that 75% of all deaths following thermal injuries are related to infection. It is essential for every hospital to determine the specific pattern of burn wound microbial colonization, time-related changes in predominant flora and anti microbial sensitivity profiles. Materials and Methods: 60 burn patients and their microbial isolates were examined during the study period. Periodic swabs were taken from burn wounds of the patients on admission and on 7th, 14th, and 21st days of hospitalization and the isolates were processed for culture, identification and antimicrobial sensitivity as per CLSI guidelines. Results: Among the 240 samples, single organism was isolated in 161 samples (67.1%) and mixed organisms in 22 samples (9.1 %) and no growth in 57 samples (23.7%). Among single isolates pseudomonas aerugenosa was predominant species (20.8%) followed by acinetobacter baumanii (15.4%), staph. aureus (14.1%) and klebsiella (7.5%). Among mixed growth pseudomonas was predominant species (30.4%) followed by acinetobacter (23.9%). klebsiella (17.4 %) and staph. aureus (10.8%). There was time related changes in bacterial isolation from burn wound during hospital stay of patients. On admission, Staph. Aureus was 18.3 %, pseudomonas was 8.3% and klebsiella was 6.6%. No growth found in 48.3% samples. These findings gradually changed with time and on day 21 Pseudomonas was 30% followed by Acinetobacter sp. (21.6%), Staph. aureus (13.3%) and Klebsella pneumoniae (6.6%). No growth was seen in 15% cases only. Antimicrobial sensitivity test showed that pseudomonas was sensitive to Imipenem, Merepenem and Ampicillin. Acinetobacter was also found most sensitive to Amikacin and Tetracycline, followed by Tobramycin. Staphylococcus aureus was sensitive to Linezolid, Gentamycin followed by Vancomycin. Conclusion: There were timerelated changes in microbial colonization during hospital stay of patients. Effective protocols should be made for burn patients and effort is needed for improving overall infection related morbidity and mortality.

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Section: Introductionmentioning

confidence: 99%

Time Related Changes in Pathogenic Bacterial Patterns in Burn Wound Infections and Their Antibiotic Sensitivity Traits

Mehta

Singh²,

Sawhney

et al. 2017

Bangladesh J Med Sci

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“…In another aspect of regenerative medicine, wound healing, electrospinning is now an established technique for the production of wound dressings for the treatment of chronic wounds [6,[29][30][31][32][33][34][35]. Many modern wound dressings are no longer only a barrier to protect a wound from infection but they are also expected to enhance the healing of the wound [36].…”

Section: Application and Importance Of Electrospun Nanofibrous Materialsmentioning

confidence: 99%

Microbial Interactions with Nanostructures and their Importance for the Development of Electrospun Nanofibrous Materials used in Regenerative Medicine and Filtration

Mortimer¹,

Burke²

2016

J Microb Biochem Technol

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“…Since then, many other antibiotics (40,42) as well as various antiseptics (43), antifungals (5), non--steroidal anti-inflammatory agents (44), anti-cancer drugs (40,45) as well as biomolecules such as proteins (5,7,21,46) and nucleic acids (47) have been built into or adsorbed on nanofibers. For example, Choi and his colleagues bound the recombinant human epidermal growth factor on the surface of polycaprolactone and poly(ethylene oxide) nanofibers and proved that the growth factor retained its biological activity (7).…”

Section: Nanofibers As Progressive Dressings For Chronic Wound Therapymentioning

confidence: 99%

Nanofibers and their biomedical use

Rošic¹,

Kocbek²,

Pelipenko³

et al. 2013

Acta Pharmaceutica

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The idea of creating replacement for damaged or diseased tissue, which will mimic the physiological conditions and simultaneously promote regeneration by patients’ own cells, has been a major challenge in the biomedicine for more than a decade. Therefore, nanofibers are a promising solution to address these challenges. These are solid polymer fibers with nanosized diameter, which show improved properties compared to the materials of larger dimensions or forms and therefore cause different biological responses. On the nanometric level, nanofibers provide a biomimetic environment, on the micrometric scale three-dimensional architecture with the desired surface properties regarding the intended application within the body, while on the macrometric scale mechanical strength and physiological acceptability. In the review, the development of nanofibers as tissue scaffolds, modern wound dressings for chronic wound therapy and drug delivery systems is highlighted. Research substantiates the effectiveness of nanofibers for enhanced tissue regeneration, but ascertains that evidences from clinical studies are currently lacking. Nevertheless, due to the development of nano- and bio-sciences, products on the market can be expected in the near future.

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Nanofibers Offer Alternative Ways to the Treatment of Skin Infections

Cited by 79 publications

References 105 publications

Time Related Changes in Pathogenic Bacterial Patterns in Burn Wound Infections and Their Antibiotic Sensitivity Traits

Time Related Changes in Pathogenic Bacterial Patterns in Burn Wound Infections and Their Antibiotic Sensitivity Traits

Microbial Interactions with Nanostructures and their Importance for the Development of Electrospun Nanofibrous Materials used in Regenerative Medicine and Filtration

Nanofibers and their biomedical use

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