Microbial Interactions with Nanostructures and their Importance for the Development of Electrospun Nanofibrous Materials used in Regenerative Medicine and Filtration

Mortimer, Chris J.; Burke, Luke

doi:10.4172/1948-5948.1000285

Cited by 15 publications

(12 citation statements)

References 63 publications

(71 reference statements)

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“…In recent research, not only PA, but also PEO [ 56 ], polyacrylonitrile (PAN) [ 57 ], and polylactide/polyhydroxybutyrate (PLA/PHB) [ 58 ] electrospun filters were proven to be suitable filtration membranes. The common shortcoming of these studies is that after filtration, the captured bacteria contaminate the nanomaterial and might cause further biofilm formation [ 55 , 59 , 60 ]. This problem was observed and discussed in detail in the study of Rysanek et al [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Benefits of Polyamide Nanofibrous Materials: Antibacterial Activity and Retention Ability for Staphylococcus Aureus

et al. 2021

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Although nanomaterials are used in many fields, little is known about the fundamental interactions between nanomaterials and microorganisms. To test antimicrobial properties and retention ability, 13 electrospun polyamide (PA) nanomaterials with different morphology and functionalization with various concentrations of AgNO3 and chlorhexidine (CHX) were analyzed. Staphylococcus aureus CCM 4516 was used to verify the designed nanomaterials’ inhibition and permeability assays. All functionalized PAs suppressed bacterial growth, and the most effective antimicrobial nanomaterial was evaluated to be PA 12% with 4.0 wt% CHX (inhibition zones: 2.9 ± 0.2 mm; log10 suppression: 8.9 ± 0.0; inhibitory rate: 100.0%). Furthermore, the long-term stability of all functionalized PAs was tested. These nanomaterials can be stored at least nine months after their preparation without losing their antibacterial effect. A filtration apparatus was constructed for testing the retention of PAs. All of the PAs effectively retained the filtered bacteria with log10 removal of 3.3–6.8 and a retention rate of 96.7–100.0%. Surface density significantly influenced the retention efficiency of PAs (p ≤ 0.01), while the effect of fiber diameter was not confirmed (p ≥ 0.05). Due to their stability, retention, and antimicrobial properties, they can serve as a model for medical or filtration applications.

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Section: Resultsmentioning

confidence: 99%

Benefits of Polyamide Nanofibrous Materials: Antibacterial Activity and Retention Ability for Staphylococcus Aureus

et al. 2021

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“…However, from the existing reports, it can be established that the mechanism occurs by several stages [146][147][148][149][150], which are summarized below:…”

Section: Antimicrobial Mechanism Of Electrospun Fibers Based On Biopolymers and Nanoparticlesmentioning

confidence: 99%

Comprehensive review on electrospinning techniques as versatile approaches toward antimicrobial biopolymeric composite fibers

Rodríguez-Tobías¹,

Morales²,

Grande

2019

Materials Science and Engineering: C

147

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Electrospun (bio)polymeric fibers have attracted widespread interest as functional materials with suitable morphology and properties for their use as tissue engineering scaffolds and/or wound dressings. The fibrous/porous morphology of this type of materials promotes the adhesion and proliferation of tissue cells, but on the other hand, pathogenic microorganisms unfortunately can also be attached to the fibers, thus leading to serious infections and consequently to the immediate removal of the scaffolds or wound dressings, which may imply greater tissue damage. In this context, this review addresses the more recent approaches based on electrospinning and related techniques for developing composite (bio)polymeric fibers with tailored antimicrobial properties either by using mere electrospinning for the incorporation of well-defined antimicrobial nanoparticles (silver, gold, titanium dioxide, zinc oxide, copper oxide, etc.) or by resorting to the combination of electrospraying and electrospinning for the generation of nanoparticle-coated fibers, as well as coaxial electrospinning for obtaining fibers with nanoparticle-rich surface.

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“…Example polymers for use Type colonisation of bacteria on these materials is still not completely understood but is essential to aid their future development [62].…”

Section: Crosslinking Agentmentioning

confidence: 99%

Electrospinning of Functional Nanofibers for Regenerative Medicine: From Bench to Commercial Scale

Mortimer¹,

Widdowson²,

Wright³

2018

Novel Aspects of Nanofibers

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Nanofibers are an important material for regenerative medicine as they have a commensurate morphology to that of the macromolecular matrix that supports and houses the growth of cells and tissues within the body. Electrospinning is widely used to fabricate non-woven structures on the nanoscale and the versatility of the technique has widened the application of nanofibers. This is due to ease of extending nanofiber functionality through the incorporation of active materials both during and after electrospinning. Recent developments in electrospinning devices, such as needle-free systems, have reinvigorated research as these advances now allow fabrication of nanofibers at commercial scales. The process of electrospinning has a number of operating parameters that are adjusted in optimisation to achieve ideal fibres and a multitude of instrument configurations can be adopted to achieve the required manufacture. The innate properties of nanofibers, such as high surface area to volume ratio, have many proven benefits for regenerative medicine and the chapter examines these before discussing how functionality can be further improved. Numerous materials can be incorporated in the manufacture of electrospun mats, however when choosing materials for regenerative medicine, biocompatibility and biodegradability are the dominant functionalities that are required.

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Microbial Interactions with Nanostructures and their Importance for the Development of Electrospun Nanofibrous Materials used in Regenerative Medicine and Filtration

Cited by 15 publications

References 63 publications

Benefits of Polyamide Nanofibrous Materials: Antibacterial Activity and Retention Ability for Staphylococcus Aureus

Benefits of Polyamide Nanofibrous Materials: Antibacterial Activity and Retention Ability for Staphylococcus Aureus

Comprehensive review on electrospinning techniques as versatile approaches toward antimicrobial biopolymeric composite fibers

Electrospinning of Functional Nanofibers for Regenerative Medicine: From Bench to Commercial Scale

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