Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

Abstract

Nanofibers were prepared from polycaprolactone, polylactide and polyvinyl alcohol using Nanospider TM technology. Polyethylene glycols with molecular weights of 2 000, 6 000, 10 000 and 20 000 g/mol, which can be used to moderate the release profile of incorporated pharmacologically active compounds, served as model molecules. They were terminated by aromatic isocyanate and incorporated into the nanofibers. The release of these molecules into an aqueous environment was investigated. The influences of the molecular length and chemical composition of the nanofibers on the release rate and the amount of released polyethylene glycols were evaluated. Longer molecules released faster, as evidenced by a significantly higher amount of released molecules after 72 hours. However, the influence of the chemical composition of nanofibers was even more distinct -the highest amount of polyethylene glycol molecules released from polyvinyl alcohol nanofibers, the lowest amount from polylactide nanofibers.1939

Fabrication of multifunctional cellulose/TiO2/Ag composite nanofibers scaffold with antibacterial and bioactivity properties for future tissue engineering applications

“…These fabricated nanofibers can be efficiently used in targeted drug delivery and in both hard and soft tissue regeneration applications (Sheikh et al, 2015;Hrib et al, 2015;Li, Vepari, Jin, Kim, & Kaplan, 2006). These fabricated nanofibers can be efficiently used in targeted drug delivery and in both hard and soft tissue regeneration applications (Sheikh et al, 2015;Hrib et al, 2015;Li, Vepari, Jin, Kim, & Kaplan, 2006).…”

“…contriving them with an appropriate substitute for better bio mimicking and efficient cell infiltration potential. These fabricated nanofibers can be efficiently used in targeted drug delivery and in both hard and soft tissue regeneration applications (Sheikh et al, 2015;Hrib et al, 2015;Li, Vepari, Jin, Kim, & Kaplan, 2006). Electrospinning besides the fabrication of pristine nanofibers from different polymeric solutions is also highly attractive in the production of composite/hybrid nanofibers.…”

Altering the characterization of nanofibers by changing the electrospinning parameters and their application in tissue engineering, drug delivery, and gene delivery systems

“…There are various kinds of polymers with different structures and functional groups for fiber production 56 . Polymers exist in both forms of natural and synthetic.…”

Nanofibrous cosmetic face mask for transdermal delivery of nano gold: synthesis, characterization, release and zebra fish employed toxicity studies

“…Further, electrospun fibre masks require no preservatives, and are efficient in releasing active compounds and they could also be packed as dry sheets [22]. In order to release active compounds, they need to be wetted only at the required time [23]. Owing to their ability to allow better contact with the skin aiding a deeper penetration of the active agent [11], these have been mainly targeted to release compounds for skin healing [24], therapy [25] and cleansing [26].…”