Nanoenabled Bioseparations: Current Developments and Future Prospects

Fahmy, Sherif Ashraf; Alawak, Mohamad; Brüßler, Jana; Bakowsky, Udo; El‐Sayed, Mayyada M. H.

doi:10.1155/2019/4983291

Cited by 23 publications

(14 citation statements)

References 97 publications

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“…Another recent study reported PDT combined with curcumin-loaded magnetic/photoresponsive liposomes (MPLs) in treating papillomavirus-related cancers ( Figure 5 ) [ 87 ]. Citric acid-coated iron oxide (CMNPs) magnetic nanoparticles are synthesized employing the chemical precipitation method [ 88 ]. Liposomes were prepared using thin-film hydration technique and lipid mixtures in a molar ratio of 5 DSPC: 3 Chol: 1 DDAB (1,2-stearoyl-sn-glycero-3-phosphocholine, dimethyl octadecyl ammonium bromide).…”

Section: Liposomal Photosensitizer Formulations For Tumor Photodynamic Therapymentioning

confidence: 99%

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

2021

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Photodynamic therapy (PDT) is a promising non-invasive strategy in the fight against that which circumvents the systemic toxic effects of chemotherapeutics. It relies on photosensitizers (PSs), which are photoactivated by light irradiation and interaction with molecular oxygen. This generates highly reactive oxygen species (such as 1O2, H2O2, O2, ·OH), which kill cancer cells by necrosis or apoptosis. Despite the promising effects of PDT in cancer treatment, it still suffers from several shortcomings, such as poor biodistribution of hydrophobic PSs, low cellular uptake, and low efficacy in treating bulky or deep tumors. Hence, various nanoplatforms have been developed to increase PDT treatment effectiveness and minimize off-target adverse effects. Liposomes showed great potential in accommodating different PSs, chemotherapeutic drugs, and other therapeutically active molecules. Here, we review the state-of-the-art in encapsulating PSs alone or combined with other chemotherapeutic drugs into liposomes for effective tumor PDT.

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Section: Liposomal Photosensitizer Formulations For Tumor Photodynamic Therapymentioning

confidence: 99%

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

2021

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“…Consequently, several delivery systems, including liposomes, macrocycles, and polymeric nanoparticles, were reported to significantly enhance the therapeutic effects of various natural and synthetic drugs [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Some natural and synthetic polymers were found to have healing properties by improving proliferation and increasing the cell count.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Coated PLGA Nanoparticles Loaded with Peganum harmala Alkaloids with Promising Antibacterial and Wound Healing Activities

et al. 2021

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Wound healing is a major healthcare concern, and complicated wounds may lead to severe outcomes such as septicemia and amputations. To date, management choices are limited, which warrants the search for new potent wound healing agents. Natural products loaded in poly (lactic-co-glycolic acid) (PLGA) coated with chitosan (CS) constitute a promising antibacterial wound healing formulation. In this work, harmala alkaloid-rich fraction (HARF) loaded into PLGA nanoparticles coated with chitosan (H/CS/PLGA NPs) were designed using the emulsion-solvent evaporation method. Optimization of the formulation variables (HARF: PLGA and CS: PLGA weight ratios, sonication time) was performed using the 33 Box–Behnken design (BBD). The optimal NPs were characterized using transmission electron microscopy (TEM) and Attenuated Total Reflection Fourier-Transformed Infrared Spectroscopy (ATR-FTIR). The prepared NPs had an average particle size of 202.27 ± 2.44 nm, a PDI of 0.23 ± 0.01, a zeta potential of 9.22 ± 0.94 mV, and an entrapment efficiency of 86.77 ± 4.18%. In vitro drug release experiments showed a biphasic pattern where an initial burst of 82.50 ± 0.20% took place in the first 2 h, which increased to 87.50 ± 0.50% over 72 h. The designed optimal H/CS/PLGA NPs exerted high antibacterial activity against Staphylococcus aureus and Escherichia coli (MIC of 0.125 and 0.06 mg/mL, respectively) compared to unloaded HARF (MIC of 0.50 mg/mL). The prepared nanoparticles were found to be biocompatible when tested on human skin fibroblasts. Moreover, the wound closure percentage after 24 h of applying H/CS/PLGA NPs was found to be 94.4 ± 8.0%, compared to free HARF and blank NPs (68.20 ± 5.10 and 50.50 ± 9.40%, respectively). In conclusion, the three components of the developed nanoformulation (PLGA, chitosan, and HARF) have synergistic antibacterial and wound healing properties for the management of infected wounds.

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“…It is a simple, cost-effective, and efficient approach in contrast to conventional methods [17] . MNPs offer various advantages like lower aggregation, enormous surface area, easy modulation under EMF, one-pot separation, and flexible particle size [109] , [110] , [111] . Moreover, the efficiency of magnetic bioseparation can be enhanced by surface functionalization of MNPs with various biocompatible polymers, organic and inorganic biomolecules [109] .…”

Section: Biomedical Application Of Hp-mnpsmentioning

confidence: 99%

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Kush

Kumar

Singh

et al. 2021

Asian Journal of Pharmaceutical Sciences

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This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.

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Nanoenabled Bioseparations: Current Developments and Future Prospects

Cited by 23 publications

References 97 publications

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

Liposome Photosensitizer Formulations for Effective Cancer Photodynamic Therapy

Chitosan-Coated PLGA Nanoparticles Loaded with Peganum harmala Alkaloids with Promising Antibacterial and Wound Healing Activities

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

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