Nanoemulsions of essential oils to improve solubility, stability and permeability: a review

Barradas, Thaís Nogueira; Silva, Káttya Gyselle de Holanda e

doi:10.1007/s10311-020-01142-2

Cited by 125 publications

(64 citation statements)

References 142 publications

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“…They can also deliver phytochemicals and other bioactive components in the food industry (Mahmood et al 2017 ). In addition, nanoemulsions also have multifarious prospects in non-food applications shown recently in inflammatory and periodontitis treatment, agrochemical, cosmetics and pharmaceutics, texturizing agents and creams, non-steroidal anti-inflammatory drug, drug and vaccine delivery, cosmeceutical applications and alcohol-free perfume formulations (Aithal et al 2018 ; Teo et al 2017 ; Bakshi et al 2018 ; Lu et al 2018 ; Kaci et al 2018 ; Salim et al 2018 ; Pengon et al 2018 ; Rai et al 2018 ; Shaker et al 2019 ; Kumar et al 2019 ; Barradas and e Silva 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…As building blocks of polymers, nanoemulsions could use their hydrophobic monomeric units in the droplets to generate polymers, with vast examples demonstrated in the studies of Asua ( 2002 ), Landfester ( 2006 ) and Gupta et al ( 2016 ). Interestingly, from the development of varying protein shell structures with silicone oil-based nanoemulsions (Chang et al 2008 ), amphiphilic photoreactive surfactants (de Oliveira et al 2011 ), silica nanospheres (Wu et al 2013 ), photoinduced and thermoreactive polymers or organogels (Helgeson et al 2012 ), essential oils-based products (Barradas and e Silva 2020 ), suspended magnetic nanoparticles (Primo et al 2007 ), to erythrocyte-like composite hydrogels (An et al 2013 ), nanoemulsions have been studied or applied.…”

Section: Nanoemulsion Applicationsmentioning

confidence: 99%

“…Moreover, nanoemulsions could be used in composite and crystal formulations on the premise of size specificity and accuracy of active pharmaceutical ingredients and other products, involving a low energy-requiring process (Eral et al 2014 ). Indeed, nanosized oil-loaded droplets ensure penetration of the stratum corneum, making them highly useful in alcohol-free perfume formulations (Rai et al 2018 ; Barradas and e Silva 2020 ). Noteworthy to mention is that some oils used in nanoemulsions proffer some benefits that should not be undermined, and could be useful in the encapsulation of volatile components like aromatic compounds and essential oils.…”

Section: Nanoemulsion Applicationsmentioning

confidence: 99%

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Nanoemulsions for health, food, and cosmetics: a review

Ashaolu

2021

Environ Chem Lett

133

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Nanoemulsions are gaining importance in healthcare and cosmetics sectors as a result of the unique properties of nanosized droplets, such as high surface area. Here we review nanotechnology and nanoemulsions with focus on emulsifiers and nanoemulsifiers, and applications for drugs and vaccines delivery, cancer therapy, inflammation treatment, cosmetics, perfumes, polymers, and food. We discuss nanoemulsion safety and properties, e.g., stability, emulsification, solubility, molecular number and arrangements, ionic strength, pH and temperature.

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Section: Discussionmentioning

confidence: 99%

Section: Nanoemulsion Applicationsmentioning

confidence: 99%

Section: Nanoemulsion Applicationsmentioning

confidence: 99%

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Nanoemulsions for health, food, and cosmetics: a review

Ashaolu

2021

Environ Chem Lett

133

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“…Core/sheath-structured nanofibers of CO have also been successfully tested for antimicrobial activity [28]. It is noteworthy that NEs are the most suitable formulation of essential oils such as CO [17]. Some NE formulations of CO have been reported for therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

“…A nanoemulsion (NE) is an advanced delivery platform suitable for the enhancement of parameters such as solubility and stability [ 17 ]. Nanoemulsions consist of nanosized oil droplets stabilized by a mixture of surfactants and co-surfactants, and they are widely studied as drug delivery platforms [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

et al. 2021

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Oral health is a key contributor to a person’s overall health and well-being. Oral microbiota can pose a serious threat to oral health. Thus, the present study aimed to develop a cinnamon oil (CO)-loaded nanoemulsion gel (NEG1) to enhance the solubilization of oil within the oral cavity, which will enhance its antibacterial, antifungal, and analgesic actions against oral microbiota. For this purpose, the CO-loaded nanoemulsion (CO-NE) was optimized using I-optimal response surface design. A mixture of Pluracare L44 and PlurolOleique CC 497 was used as the surfactant and Capryol was used as the co-surfactant. The optimized CO-NE had a globule size of 92 ± 3 nm, stability index of 95% ± 2%, and a zone of inhibition of 23 ± 1.5 mm. This optimized CO-NE formulation was converted into NEG1 using 2.5% hydroxypropyl cellulose as the gelling agent. The rheological characterizations revealed that the NEG1 formulation exhibited pseudoplastic behavior. The in vitro release of eugenol (the marker molecule for CO) from NEG1 showed an enhanced release compared with that of pure CO. The ex vivo mucosal permeation was found to be highest for NEG1 compared to the aqueous dispersion of CO-NE and pure cinnamon oil. The latency reaction time during the hot-plate test in rats was highest (45 min) for the NEG1 sample at all-time points compared with those of the other tested formulations. The results showed that the CO-NEG formulation could be beneficial in enhancing the actions of CO against oral microbiota, as well as relieving pain and improving overall oral health.

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Eucalyptus Essential Oil Based Nanoemulsions: Preparation and Biological Activities

Rehman,

Hussain,

Muzaffar

et al. 2024

Chemistry & Biodiversity

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Eucalyptus essential oil has remarkable industrial importance and biological properties due to its effectiveness against various diseases, reported throughout human history. Despite the extraordinary bioactivities of essential oil, its applications are limited due to volatility, insolubility in water, and less stability. Formulation of nanoemulsion is the best way to enhance the bio‐efficacy of this essential oil and eliminate the factors responsible for limited application. This review article compiles the information regarding formulation of Eucalyptus essential oil‐based nanoemulsion and their several biological activities and medicinal properties including antibacterial, antifungal, larvicidal, insecticidal, and cytotoxic activities etc. The bio‐efficacy of essential oil‐based nanoemulsion has also been found to be enhanced as compared utilization of essential oil alone. This review can be beneficial for researchers working on medicinal plant‐based natural products, specifically containing Eucalyptus essential oil, to explore new research horizons in this emerging field.

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Nanoemulsions of essential oils to improve solubility, stability and permeability: a review

Cited by 125 publications

References 142 publications

Nanoemulsions for health, food, and cosmetics: a review

Nanoemulsions for health, food, and cosmetics: a review

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

Eucalyptus Essential Oil Based Nanoemulsions: Preparation and Biological Activities

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