Nanoemulsion as a Valuable Nanostructure Platform for Pharmaceutical Drug Delivery

Patel, Rashmin B.; Patel, Mrunali R.; Thakore, Shivam D.; Patel, Bankim

doi:10.1016/b978-0-323-52727-9.00017-0

Cited by 21 publications

(15 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Microemulsions (mean droplet size 100–400 nm [ 152 ]) and nanoemulsions (1 to 100 nm [ 153 ]) are isotropic dispersions of two non-miscible liquids (oil and water). The former is thermodynamically stable system in which the inner phase can figure as spheroid, cylinder-like, plane-like, or as a bicontinuous structure [ 154 ], whereas the latter is thermodynamically unstable, usually requiring a co-surfactant because its free energy is higher than the free energy of the separate oil and water [ 155 ].…”

Section: Eos Encapsulation Strategies In Drug Delivery Systemsmentioning

confidence: 99%

Essential Oils: Pharmaceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems

et al. 2021

View full text Add to dashboard Cite

Essential oils are being studied for more than 60 years, but a growing interest has emerged in the recent decades due to a desire for a rediscovery of natural remedies. Essential oils are known for millennia and, already in prehistoric times, they were used for medicinal and ritual purposes due to their therapeutic properties. Using a variety of methods refined over the centuries, essential oils are extracted from plant raw materials: the choice of the extraction method is decisive, since it determines the type, quantity, and stereochemical structure of the essential oil molecules. To these components belong all properties that make essential oils so interesting for pharmaceutical uses; the most investigated ones are antioxidant, anti-inflammatory, antimicrobial, wound-healing, and anxiolytic activities. However, the main limitations to their use are their hydrophobicity, instability, high volatility, and risk of toxicity. A successful strategy to overcome these limitations is the encapsulation within delivery systems, which enable the increase of essential oils bioavailability and improve their chemical stability, while reducing their volatility and toxicity. Among all the suitable platforms, our review focused on the lipid-based ones, in particular micro- and nanoemulsions, liposomes, solid lipid nanoparticles, and nanostructured lipid carriers.

show abstract

Section: Eos Encapsulation Strategies In Drug Delivery Systemsmentioning

confidence: 99%

Essential Oils: Pharmaceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In contrast to microemulsions, nanoemulsions diluted with water remain stable without changing the droplet size distribution; this stability is influenced by changes in temperature and pH [21]. Lesser toxic formulation, kinetically stable systems, targeting applications, and aesthetic features forced the pharmaceutical researchers to work on nano-emulsion [50].…”

Section: Nanoemulsionsmentioning

confidence: 99%

Lipid Based Drug Delivery System: A Review

Zubair

Sheshe

Bashir

et al. 2021

JALSI

View full text Add to dashboard Cite

Associated with the old/traditional of method of drug delivery are several limitation ranging from first-pass effect, low tolerance, minimal bioavailability, fluctuation of plasma drug concentration which result to less or no desired effect produced. This call for the demand for a more efficient drug administration technique. Lipid systems are biocompatible, inert and biodegradable, stable and deliver at the target with the desired effect. This paper attempt to describe several types of lipid particles used to deliver drug compounds and their applications as therapeutic agent in treating different clinical condition.

show abstract

“…TPD and pTPD are of enormous importance in deducing the various types of microemulsions that may be obtained with certain surfactant/co‐surfactant, oil, and water concentrations. Previous research has primarily focused on spontaneous emulsification or phase titration methods as documented by Rajpoot and Tekade (2020), Patel et al (2017), and Talegaonkar et al (2016). Though useful, these oil‐ and water‐titration methods result in a narrow region of microemulsion formation within a TPD, neglecting other potentially important regions.…”

Section: Introductionmentioning

confidence: 99%

Phase Behavior of Non‐Ionic Surfactant‐Medium Chain Triglyceride‐Water Microemulsion Systems

Callender

Wettig

2021

J Surfact & Detergents

View full text Add to dashboard Cite

show abstract

Nanoemulsion as a Valuable Nanostructure Platform for Pharmaceutical Drug Delivery

Cited by 21 publications

References 66 publications

Essential Oils: Pharmaceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems

Essential Oils: Pharmaceutical Applications and Encapsulation Strategies into Lipid-Based Delivery Systems

Lipid Based Drug Delivery System: A Review

Phase Behavior of Non‐Ionic Surfactant‐Medium Chain Triglyceride‐Water Microemulsion Systems

Contact Info

Product

Resources

About