Nanoemulsion as a topical delivery system of antipsoriatic drugs

Salim, Norazlinaliza; Ahmad, Noraini; Musa, Siti Hajar; Hashim, Roslan; Tadros, Tharwat F.; Basri, Mahiran

doi:10.1039/c5ra14946k

Cited by 62 publications

(34 citation statements)

References 152 publications

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“…MASOUMI 1 , M. BASRI 1 , S.S. DA COSTA 1 and N. AHMAD 2 methods: either using high-energy or low-energy emulsification methods (both covering the particle size ranging less than 500 nm) [7,8]. High energy emulsification methods include high pressure homogeniser, microfluidization and ultrasonication, while the low energy emulsification method include phase inversion composition (PIC), phase inversion temperature (PIT) and dilution of microemulsion [9].…”

Section: Optimization Of Hydrocortisone-loaded Nanoemulsion Formulatimentioning

confidence: 99%

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Kong¹,

Salim²,

Masoumi³

et al. 2018

Asian J. Chem.

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Optimization of hydrocortisone-loaded nanoemulsion formulation was achieved by low energy emulsification method. D-optimal mixture design was used with the variables parameters of Tween-20, lipoid S75, palm kernel oil ester (PKOE) and deionized water towards a response (viscosity). Hydrocortisone, ethanol and phenonip were kept constant (1.0, 24 and 0.5 wt. %). The mixing rate and time were kept constant at 400 rpm and 4 h, respectively. The optimum formulation conditions were successfully predicted. From the results obtained, it shows that the higher the concentration of palm kernel oil ester, the less the viscosity of the nanoemulsion. The optimized formulation showed good stability with the viscosity of 2.85 Pa.s. The particle size, polydispersity index and zeta potential of the optimized nanoemulsion gave a result of 172.56 nm, 0.184 and-50.03 mV, respectively. The results are in agreement with the TEM micrograph. The viscosity of the optimized nanoemulsion decreased with increased shear rate, showing a shear thinning behaviour (pseudoplastic) suitable for pharmaceutical application.

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Section: Optimization Of Hydrocortisone-loaded Nanoemulsion Formulatimentioning

confidence: 99%

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Kong¹,

Salim²,

Masoumi³

et al. 2018

Asian J. Chem.

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“…17 Though many options are offered by topical treatment, such complications as staining, bad odor, side effects, and difficulty in application have limited their usage. 15, 18 Malik et al has reported hijama as a traditional topical treatment for treating psoriasis. However, this treatment is not very practical, since it needs to be performed in aseptic conditions by a well-trained hijama physician.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action

Sh¹,

Basri²,

HR³

et al. 2017

IJN

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“…Isotropic, transparent, kinetically stable; high solubilization capacity for both lipophilic & hydrophilic drugs [6] Careful selection of formulation components essential to avoid skin irritation Vesicular carriers Solid Lipid nanoparticles Solid lipid nanoparticles reported to deform in shape and melt after application to skin reducing the skin barrier and causing occlusion on the skin surface favoring the penetration of the active [7,8].…”

Section: Stability Influenced By Factors Such As Ph and Temperature Chamentioning

confidence: 99%

Topical and cutaneous delivery using nanosystems

Roberts

Mohammed

Pastore

et al. 2017

Journal of Controlled Release

218

113

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The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review.

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Nanoemulsion as a topical delivery system of antipsoriatic drugs

Abstract: Nanoemulsion as a potential enhancer for the treatment of psoriasis.

Cited by 62 publications

References 152 publications

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Optimization of Hydrocortisone-Loaded Nanoemulsion Formulation Using D-Optimal Mixture Design

Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action

Topical and cutaneous delivery using nanosystems

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