Nanoemulgel: a promising novel formulation for treatment of skin ailments

Ojha, Brijesh; Jain, Vineet; Gupta, Shipra Sen; Talegaonkar, Sushama; Jain, Keerti

doi:10.1007/s00289-021-03729-3

Cited by 33 publications

(23 citation statements)

References 71 publications

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“…These microbial characteristics are responsible for the development of drug resistance, and thus conventional antimicrobial therapy did not work. This condition requires combinatorial therapies (combination of two different therapies like combination of chemotherapy and radiotherapy) or multitargeted drug delivery systems [42] , [43] , [44] . Other challenges associated with treatment of infectious diseases are lack of economic prospects for investment in this field, and hence approaches aiming at the rational design of compounds, such as structure-based drug discovery (SBDD), fragment screening, target-based drug discovery, and drug repurposing should be given special interest [45] .…”

Section: Challenges Associated With Treatment Of Infectious Diseasesmentioning

confidence: 99%

Emerging concerns of infectious diseases and drug delivery challenges

Bagre¹,

Patel²,

Naqvi³

et al. 2022

Nanotheranostics for Treatment and Diagnosis of Infectious Diseases

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Section: Challenges Associated With Treatment Of Infectious Diseasesmentioning

confidence: 99%

Emerging concerns of infectious diseases and drug delivery challenges

Bagre¹,

Patel²,

Naqvi³

et al. 2022

Nanotheranostics for Treatment and Diagnosis of Infectious Diseases

Self Cite

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“…In this phase, the NEs were centrifuged at 5,000 rpm for 30 minutes to check for creaming, phase separation, and cracking (Ma et al, 2021;Ojha et al, 2021).…”

Section: Centrifugationmentioning

confidence: 99%

A co-additive nanoemulgel formulation of tretinoin and curcumin: Formulation and optimization

Phaugat¹,

Nishal²,

Dutt³

et al. 2022

j app pharm sci

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Tretinoin (TRT), a natural all-trans retinoic acid occurring retinoid metabolite, belongs to the first generation of retinoids used to treat various skin ailments, like acne vulgaris and skin ageing and psoriasis. In this study, a combination of drugs using TRT and curcumin (CUR) nanoemulsion (NE) is fabricated, and is further added to a gel formulation to boost the efficacy and stability of the topical formulation. A high-energy sonication technique was used in the NE fabrication, and optimization was carried out using the Box-Behnken design. The TRT-CUR-NEs were found to have a mean particle size, zeta potential, and PDI of 77.6 ± 2.1 nm, −20.7 ± 4.4 mV, and 0.268 ± 0.029, respectively. The optimized formulation of TRT-CUR-NE has a % entrapment efficiency of 85.92% ± 2.6% and 88.31% ± 3.2% for TRT and CUR, respectively, and a % loading efficiency of 19.6% ± 1.2% and 18.7% ± 2.5%, respectively, for TRT and CUR, respectively. The in vitro release profile displayed % cumulative drug release of 28.64% ± 0.31%, 80.32% ± 0.42%, and 89.64% ± 0.97% after 24 hours for plain gel, TRT-CUR-NE, and TRT-CUR-nanoemulgel, respectively.

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“…The participants were asked to apply each formulation between their fingers and rate 11 attributes on a Likert scale of 1-5 (1 = lowest and 5 = highest). The 11 rated attributes were described in detail in the work of Kulawik-Pioro et al 15 The participants rated the nanoemulgel and the placebo formulation for (1) irritation, (2) appearance, (3) color, (4) odor, (5) consistency, (6) adhesion, (7) sensation, (8) cohesiveness, (9) spreadability, (10) stickiness, and (11) greasiness/oiliness.…”

Section: Sensory Evaluation Of the Novel Grapeseed Oil-loaded Dermoco...mentioning

confidence: 99%

“…Nanocarrier systems like nanoparticles, nanotubes, noisomes, and nanoemulsions have emerged as novel techniques in the delivery of drugs and other bioactive compounds. 6,10,11 Nanoemulsions have emerged as isotropic heterogeneous mixtures of oils, water, and surfactants in which either water or oils are dispersed in the other phase (either oil or water) which would constitute the continuous phase. 12 The dispersion is stabilized by an interfacial film that is formed by the surfactants.…”

Section: Introductionmentioning

confidence: 99%

“…It has been argued that transdermal delivery of drugs and other bioactive compounds from nanoemulsions can be improved by incorporating nanoemulsions into emulgels to form nanoemulgels. 10 In a previous study, Muscat hamburg black grapeseed extract was formulated into a water-in-oil emulsion. 13 After 8 weeks of application, the formulation produced significant reductions in melanin, sebum production, and improved skin elasticity compared to placebo as measured using non-invasive skin evaluation techniques.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split‐face, blinded, placebo‐controlled study

Shawahna

2022

J of Cosmetic Dermatology

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Background: Worldwide, grapes (Vitis vinifera L.; family: Vitaceae) are one of the most important fruits. Grapeseed oil is rich in bioactive constituents that could be beneficial to the health and aesthetic features of human skin.Objective: This study was conducted to evaluate the effects of a novel grapeseed oilloaded dermocosmetic nanoemulgel on biophysical parameters of facial skin.Methods: This was a split-face, blinded, placebo-controlled study. A novel grapeseed oil-loaded dermocosmetic nanoemulgel was developed, and its effects on the biophysical parameters of the facial skin were evaluated and compared to those of a placebo formulation on the cheeks of 15 healthy volunteers. Melanin, erythema, sebum production, fine and large facial pores, moisture, and elasticity levels were measured using Mexameter®, Corneometer®, Sebumeter®, Cutometer®, and VisioFace®.Measurements were made on weekly basis for 12 weeks.Results: Compared to the placebo, the novel grapeseed oil-loaded dermocosmetic nanoemulgel received significantly higher sensory scores with regard to appearance, color, odor, consistency, adhesion, sensation, cohesiveness, and spreadability (p-value < 0.05). Additionally, the novel nanoemulgel continuously and significantly reduced skin melanin, erythema, sebum production, and fine and large pores (pvalue < 0.05). On the contrary, the novel nanoemulgel continuously and significantly increased skin moisture contents and elasticity (p-value < 0.05). Conclusion:The novel grapeseed oil-loaded dermocosmetic nanoemulgel had attractive cosmetic attributes that could be useful for improving imperfections of the human skin. Future studies are still needed to test and evaluate the benefits of this novel grapeseed oil-loaded dermocosmetic nanoemulgel in disease conditions.

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Nanoemulgel: a promising novel formulation for treatment of skin ailments

Cited by 33 publications

References 71 publications

Emerging concerns of infectious diseases and drug delivery challenges

Emerging concerns of infectious diseases and drug delivery challenges

A co-additive nanoemulgel formulation of tretinoin and curcumin: Formulation and optimization

Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split‐face, blinded, placebo‐controlled study

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