Nanodrug Delivery for Tumor Treatment

Kleinstreuer, Clement

doi:10.1007/978-3-642-27758-0_1750-3

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…This model was used to investigate the particle haemodynamics of Yttrium‐90‐based microspheres targeting carcinogenic liver cells. A representative scheme of the hepatic arterial system (two generations with four outflows) and a patient‐specific hepatic arterial system (one generation with two outflows) were created and the representative one was adopted in subsequent studies to investigate drug delivery mechanisms for treating liver tumour . Further, to the study of Basciano, a one‐dimensional (1D) computational model was devised to simulate arterial pressure and blood flow rates in the liver, which produced results of similar physiological accuracy to a 3D model‐based ones but at a reduced computational cost .…”

Section: Introductionmentioning

confidence: 99%

Anatomically based simulation of hepatic perfusion in the human liver

Hunter

Cousins³

et al. 2019

Numer Methods Biomed Eng

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Liver structures of a healthy subject are digitised and segmented from computed tomography (CT) images, and hepatic perfusion is modelled in the hepatic artery and portal vein of the healthy subject with structured tree‐based outflow boundary conditions. This self‐similar structured tree is widely used in the literature, eg, blood flow simulation in larger systemic arteries and cerebral circulation, and is used in this study to model the effect of the smaller hepatic arteries and arterioles, as well as the smaller hepatic portal veins and portal venules. Physiologically reasonable results are obtained. Since the structured tree terminates at the size of the microvasculature system in liver lobules, the structured tree boundary condition will enable the proposed organ‐level model of hepatic arterial flow to be easily connected to tissue‐level models of liver lobules. Blood flow in the hepatic vein is also modelled in this subject with three‐element Windkessel model as outflow boundary conditions. The benefit of integrating the perfusion in all hepatic vascular vessels is that it helps us analyse some complicated clinical phenomenon more efficiently, eg, one possible application is to obtain the portal pressure gradient (PPG) to help examine the reliability of hepatic venous pressure gradient (HVPG) as an indirect measure of portal pressure. Moreover, since four to six generations of hepatic vessels, which are sufficient for liver classification analysis, were employed in the model, this study is setting the computational foundation of a potentially handy surgical tool.

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Section: Introductionmentioning

confidence: 99%

Anatomically based simulation of hepatic perfusion in the human liver

Hunter

Cousins³

et al. 2019

Numer Methods Biomed Eng

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show abstract

“…Specifically, pressure and shear forces become dominant due to the small scale of the system. 43 Additionally, the capillary effect, a surface effect, is particularly prominent in microchannels with a bore diameter equal to or less than 50 μm. This effect is a result of the smaller size of the channels and the high surface-to-volume ratio of the components.…”

Section: Microfluidics and Nanofluidics: Next-gen Point-of-care Lab-o...mentioning

confidence: 99%

“…Although microscale material properties are the same as macro scale, the same nanomaterial may exhibit different thermal and electric conduction, optical behavior, and surface reactions, often due to rearranged lattice atoms or molecules. 43 Like microfluidics, nanofluidics systems also include supply reservoirs, flow conduits, passive or active pumps, actuators, valves, sensors, heaters, etc. 47…”

Section: Microfluidics and Nanofluidics: Next-gen Point-of-care Lab-o...mentioning

confidence: 99%