Nanodispersed UV blockers in skin-friendly silica vesicles with superior UV-attenuating efficiency

Zhang, Jun; Raphael, Anthony P.; Yang, Yannan; Popat, Amirali; Prow, Tarl W.; Yu, Chengzhong

doi:10.1039/c4tb01332h

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…Minimizing the depth of disrupted skin would reduce the risk of systemic exposure and dermal inflammation. EMPs have the potential to significantly enhance topical drug delivery [14,15,19] while limiting mechanical penetration to the viable epidermis.…”

Section: Discussionmentioning

confidence: 99%

Elongated microparticles tuned for targeting hyaluronic acid delivery to specific skin strata

Yamada

Dang

Lin

et al. 2021

Intern J of Cosmetic Sci

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Objective: Microneedle or fractional laser applications are the most common topical delivery enhancement platforms. However, these methods of drug delivery are not skin strata specific. Drug delivery approaches which could target specific stratum of the skin remains a challenge. Elongated microparticles (EMPs) have been used in enhancing drug delivery into the skin. The aim of this study was to evaluate, for the first time, elongated silica microparticles with two different length profiles to enhance delivery of hyaluronic acid into different strata of human skin.Methods: Two types of EMPs-long (milled EMPs) or short (etched EMPs) length ranges were characterized. A prototypical liquid formulation (Fluorescent hyaluronic acid) with and without EMP enhancement were evaluated for hyaluronic acid delivery in ex-vivo human skin. High performance liquid chromatography, Typhoon fluorescence scanning system, laser scanning confocal microscopy and reflectance confocal microscopy (RCM) were used to validate F-HA stability, visualize fluorescein in the skin, image the depth of F-HA delivery in the skin and define EMP penetration in skin strata, respectively. Statistical analysis was conducted using GraphPad Prism 6 software (GraphPad Software Inc, USA). Results: Fluorescein-hyaluronic acid was stable and EMP enhanced skin penetration. RCM revealed that 'etched EMP' penetrated the skin to the stratum spinosum level. The vast majority (97.8%; p < 0.001) of the etched EMP did not penetrate completely through the viable epidermis and no obvious penetration into the dermis. In contrast, milled EMP showed 41-fold increase in penetration compared to the etched EMP but penetrated beyond the dermoepidermal junction. Conclusion:EMPs can enhance delivery of hyaluronic acid. Using EMPs with defined length distributions, which can be tuned for a specific stratum of the skin, can achieve targeted hyaluronic acid delivery.

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Section: Discussionmentioning

confidence: 99%

Elongated microparticles tuned for targeting hyaluronic acid delivery to specific skin strata

Yamada

Dang

Lin

et al. 2021

Intern J of Cosmetic Sci

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“…Sunscreens are commonly used to mitigate sunburn, − accelerated skin aging, − and skin cancer , from UV exposure. Organic sunscreens, such as salicylates, absorb UV radiation when applied directly to skin, but have limited lifetime due to photodegradation and may be phototoxic − or photoallergenic. , The facility with which topical sunscreens absorb through skin − also raises concerns over their estrogenicity. ,, One method to improve stability and reduce transdermal transfer is to encapsulate sunscreens in matrices, such as gelatin, polymers, − lipids, cyclodextrins, − silica (SiO 2 ), − or alumina (Al 2 O 3 ), to be dispersed in lotions or cosmetics.…”

Section: Introductionmentioning

confidence: 99%

“…Sunscreens can be physically encapsulated in − or covalently attached to − silica particles. Hydrophobic sunscreens as the core of hollow silica particles can be prepared by oil-in-water (O/W) microemulsion polymerizations (Scheme ).…”

Section: Introductionmentioning

confidence: 99%

New Hybrid Organic/Inorganic Polysilsesquioxane–Silica Particles as Sunscreens

Tolbert

McFadden

Loy

2016

ACS Appl. Mater. Interfaces

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Effectiveness of organic sunscreens is limited by phototoxicity and degradation. Both of which can be significantly reduced by encapsulation in hollow particles or covalent incorporation into the solid structure of particles, but direct comparisons of the two methods have not been reported. In this study, physical encapsulation and covalent incorporation of sunscreens were compared with 1 mol % salicylate and curcumeroid sunscreens. 2-Ethylhexyl salicylate was physically encapsulated in hollow silica nanoparticles prepared by oil-in-water (O/W) microemulsion polymerizations (E-Sal). Some of these particles were coated with an additional shell or cap of silica to reduce leaking of sunscreen (cap-E-Sal). Covalent incorporation involved co-polymerizing tetraethoxysilane (TEOS) with 0.2 mol % of new salicylate and curcuminoid sunscreen monomers with triethoxsilyl groups. Particles were prepared with the salicylate attached to the silica matrix through single silsesquioxane groups (pendant; P-Sal) and two silsesquioxane groups (bridged; B-Sal). Particles based on a new curcuminoid-bridged monomer were also prepared (B-Curc). Sunscreen leaching, photodegradation, and sunscreen performance were determined for the E-Sal, cap-E-Sal, P-Sal, B-Sal, and B-Curc particles. Covalent attachment, particularly with bridged sunscreen monomers, reduced leaching and photodegradation over physical encapsulation, even with capping.

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“…[22,23] Chemically introducing hydrogel thin films onto substrate surfaces presents several advantages: (i) the surface attached hydrogel layers are much stable because the polymer networks are bonded onto substrates via many anchoring sites; [24] (ii) sufficient functional groups are introduced onto the substrates due to the 3D porous structure; [25] (iii) various drugs or proteins can be loaded into the hydrogel layers to receive bioactive surfaces. [26] Hydrogels have been widely applied in biomedical fields for their unique merits, [27] such as tissue engineering, [28] wound healing, [29] and contact lenses. [30,31] Many researchers have paid attention to attach functional hydrogel films onto substrates.…”

Section: Introductionmentioning

confidence: 99%

“…[18,38] We proposed that sufficient hydroxyl groups would be introduced onto PES surfaces via in situ cross-linking polymerization of hydroxyethyl methylacrylate (HEMA), and then provide the anchoring sites for further fabricating heparin-mimicking hydrogel thin films. Compared with the approaches of attaching hydrogel thin films onto substrates that have been reported recently, the method of creating anchoring sites in this study is simpler and more efficient, [26,37] and the formation process of the hydrogel thin films is more straightforward. [34,35] In this study, PES membrane was selected as the model substrate.…”

Section: Introductionmentioning

confidence: 99%

Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility

Cui

Jiang

et al. 2016

Macromol. Biosci.

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In this study, heparin-mimicking hydrogel thin films are covalently attached onto poly(ether sulfone) membrane surfaces to improve anticoagulant property. The hydrogel films display honeycomb-like porous structure with well controlled thickness and show long-term stability. After immobilizing the hydrogel films, the membranes show excellent anticoagulant property confirmed by the activated partial thromboplastin time values exceeding 600 s. Meanwhile, the thrombin time values increase from 20 to 61 s as the sodium allysulfonate proportions increase from 0 to 80 mol%. In vitro investigations of protein adsorption and blood-related complement activation also confirm that the membranes exhibit super-anticoagulant property. Furthermore, gentamycin sulfate is loaded into the hydrogel films, and the released drug shows significant inhibition toward E. coli bacteria. It is believed that the surface attached heparin-mimicking hydrogel thin films may show high potential for the applications in various biological fields, such as blood contacting materials and drug loading materials.

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Nanodispersed UV blockers in skin-friendly silica vesicles with superior UV-attenuating efficiency

Cited by 17 publications

References 33 publications

Elongated microparticles tuned for targeting hyaluronic acid delivery to specific skin strata

Elongated microparticles tuned for targeting hyaluronic acid delivery to specific skin strata

New Hybrid Organic/Inorganic Polysilsesquioxane–Silica Particles as Sunscreens

Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility

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