Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility

He, Min; Cui, Xiaofei; Jiang, Huiyi; Huang, Xuelian; Zhao, Weifeng; Zhao, Changsheng

doi:10.1002/mabi.201600281

Cited by 34 publications

(20 citation statements)

References 63 publications

(92 reference statements)

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“…To attach hydrogel layer onto membrane surface, the key point is to introduce anchoring sites for the hydrogel layer. In our previous studies, in situ crosslinking polymerization of 2‐hydroxyethyl methacrylate (HEMA) in PES solution was applied to introduce hydroxyl groups onto the surface as the anchoring points . However, it might cause the microstructure change, which would usually deteriorate the membrane performance.…”

Section: Resultsmentioning

confidence: 99%

“…For example, Zhao et al immersed double bonds grafted PES membrane into hydrogel precursor solution, then a free radical crosslinking polymerization was conducted to form a hydrogel thin film onto the surface . In our previous works, we developed a simple technique to covalently attach functional hydrogel thin layers onto polyethersulfone (PES) membrane surfaces, and super‐anticoagulant and robust antibacterial surfaces were prepared …”

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive Antibacterial Surfaces Switching from Bacterial Adhesion to Bacterial Repulsion

Wang

Feng

et al. 2018

Macro Materials & Eng

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/mame.201700590. Antibacterial SurfacesHerein, ene-functionalized dopamine is first coated onto a polyether sulfone membrane surface to introduce double bonds as anchoring sites for hydrogel film. Then, a hydrogel film is synthesized and simultaneously attached onto the membrane via photoinduced crosslinking copolymerization of N-isopropylacrylamide (NIPAAm) and methacryloxyethyltrimethyl ammonium chloride. The thickness of the hydrogel film can be well-controlled ranging from the nano meter to micrometer scales, which can retain the permeability of the membrane. Water contact angle and swelling tests demonstrate that the modified membrane shows thermoresponsive surface wettability. The quaternary ammonium salts in the hydrogel film can kill the attached bacteria efficiently and the dead bacteria can be detached by reducing the temperature below the lower critical solution temperature of poly(NIPAAm). The modified membrane also shows improved hemocompatibility, confirmed by prolonged clotting time and low hemolysis ratio. Hence, the designed thermoresponsive antibacterial hydrogel film with enhanced hemocompatibility has great potential to be applied in biomedical areas.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Antibacterial Surfaces Switching from Bacterial Adhesion to Bacterial Repulsion

Wang

Feng

et al. 2018

Macro Materials & Eng

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“…Interestingly, in comparison with common hemocompatibility approaches, hydrogelbased techniques could be significantly efficient. A support for such a hypothesis is a research reported by [86] who immobilized a heparin-mimicking thin film hydrogel on PES hemodialysis membrane which resulted in three times higher clotting time than best modified blood purification membranes (activated partial thromboplastin time value of 600 sec).…”

Section: Hemocompatibility Enhancementsmentioning

confidence: 94%

Challenges and Advances in Hemodialysis Membranes

Mollahosseini¹,

Abdelrasoul²,

Shoker³

2020

Advances in Membrane Technologies

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Hemodialysis (HD) is a filtration vital process through which the bloods' toxins and contaminations are removed. However, several immune system activations occur during dialysis, which can result in morbidity and mortality. The efficiency of the currently available blood purification process is hindered, on one hand, by the deficient toxins and middle molecule removal, and on the other hand, with the loss of valuable blood components (such as plasma and its constituents). This chapter offers an overview of the challenges and advances in HD membranes. It includes an introduction of the end stage renal disease, concepts of dialysis, its historical background, and the path through which the configurations and materials evolved. The interactions between membrane polymeric materials with human blood is also discussed. The aspect of material modification is one of the critical areas in HD technology as it targets to solve the most immediate and prevalent HD issue of membrane bioincompatibility. High flux dialysis (HFD) and hemofiltration (HF) are introduced and discussed. This class of membranes was introduced to solve middle molecule (such as β2-microglobulin) related challenges. This chapter highlights the question of why the issue of incompatible materials still exists along with current membrane modifications.

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“…Nonspecific protein adsorbed on the surface of vascular grafts can induce biomaterialassociated clotting or platelet adhesion and activation. [24] Low nonspecific protein adsorption is crucial for vascular grafts to prevent thrombosis, especially fibrinogen adsorption. [25] Pure PVA tubes showed adsorption amounts of albumin and fibrinogen of 2.1 and 2.8 μg cm −2 (Figure 3a), which were attributed to the high hydrophilicity of PVA tubes that prevented protein adsorption.…”

Section: Protein Adsorptionmentioning

confidence: 99%

Anticoagulant Hydrogel Tubes with Poly(ɛ‐Caprolactone) Sheaths for Small‐Diameter Vascular Grafts

Zhang

Xie

Cha

et al. 2021

Adv Healthcare Materials

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Small-diameter vascular grafts (inner diameter < 6 mm) are useful in treating cardiovascular diseases. The off-the-shelf small-diameter vascular grafts for clinical applications remain a great limitation owing to their thrombogenicity or intimal hyperplasia. Herein, bilayer anticoagulant hydrogel tubes with poly( -caprolactone) (PCL) sheaths are prepared by freeze-thawing and electrospinning, which contain nanofibrillated cellulose (NFC)/poly(vinyl alcohol) (PVA)-heparin/poly-L-lysine nanoparticles tube as an inner layer and PCL sheath as an outer layer. The structure, anticoagulant property, and biocompatibility of the inner layer are studied. The effects of thickness of the outer layer on perfusion performance and mechanical property of hydrogel tubes with PCL sheaths (PCL-NFC/PVA-NPs tubes) are investigated. The effect of compliance of PCL-NFC/PVA-NPs tubes on their blood flow is studied by numerical simulation. The tissue compatibility and the patency of PCL-NFC/PVA-NPs tubes are evaluated by implantation in subcutaneous tissue of rats and carotid artery of rabbits. PCL-NFC/PVA-NPs tubes have prominent anticoagulation, sufficient burst pressure and good compliance similar to native arteries. PCL-NFC/PVA-NPs tubes facilitate infiltration of host cells and achieve active proliferation of recruited cells, which will be a promising candidate for small-diameter vascular grafts.

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Super-Anticoagulant Heparin-Mimicking Hydrogel Thin Film Attached Substrate Surfaces to Improve Hemocompatibility

Cited by 34 publications

References 63 publications

Thermoresponsive Antibacterial Surfaces Switching from Bacterial Adhesion to Bacterial Repulsion

Thermoresponsive Antibacterial Surfaces Switching from Bacterial Adhesion to Bacterial Repulsion

Challenges and Advances in Hemodialysis Membranes

Anticoagulant Hydrogel Tubes with Poly(ɛ‐Caprolactone) Sheaths for Small‐Diameter Vascular Grafts

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