Nanodiamonds for drug delivery systems

Mengesha, Abebe; Youan, B-B.C.

doi:10.1533/9780857093516.2.186

Cited by 29 publications

(13 citation statements)

References 67 publications

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“…Cellular activity analyses at discrete time points using colorimetric detection based on WST-1 assay [21] showed that 24 h exposure to different concentrations of NDs did not induce significant effects on cell viability (figure 3(a)), thus confirming previous studies [13, 48]. Complementary, cell cycle analyses performed by measuring the percentage of the DNA content showed that NDs exposure did not alter cell cycle progression nor interfered with cellular proliferation (figure 3(b)).…”

Section: Resultssupporting

confidence: 85%

Combinatorial approaches to evaluate nanodiamond uptake and induced cellular fate

et al. 2016

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Nanodiamonds (NDs) are an emerging class of engineered nanomaterials that hold great promise for the next generation of bionanotechnological products to be used for drug and gene delivery, or for bio-imaging and biosensing. Previous studies have shown that upon their cellular uptake, NDs exhibit high biocompatibility in various in vitro and in vivo set-ups. Herein we hypothesized that the increased NDs biocompatibility is a result of minimum membrane perturbations and their reduced ability to induce disruption or damage during cellular translocation. Using multi-scale combinatorial approaches that simulate ND-membrane interactions, we correlated NDs real-time cellular uptake and kinetics with the ND-induced membrane fluctuations to derive energy requirements for the uptake to occur. Our discrete and real-time analyses showed that the majority of NDs internalization occurs within 2 h of cellular exposure, however, with no effects on cellular viability, proliferation or cellular behavior. Furthermore, our simulation analyses using coarse-grained models identified key changes in the energy profile, membrane deformation and recovery time, all functions of the average ND or ND-based agglomerate size. Understanding the mechanisms responsible for ND-cell membrane interactions could possibly advance their implementation in various biomedical applications.

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Section: Resultssupporting

confidence: 85%

Combinatorial approaches to evaluate nanodiamond uptake and induced cellular fate

et al. 2016

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“…In addition to high hardness, diamond also has high chemical and mechanical resistance, high thermal conductivity, and good electrical insulating properties, so it is mainly used to produce grinding, cutting, or drilling tools. However, it has also found its application in medicine, for example, as part of orthopedic instruments where, in the form of nanostructured coatings, the effect can be more pronounced when the layer is further modified [ 13 ], it reduces product friction, protects against wear, and thus prolongs product life; in the form of a nanodiamond, due to the small particle size, purity and functionality to functionalize their surface, for targeted drug release [ 14 ]; or as part of microfluidic devices [ 15 ].…”

Section: Carbon Nanostructures and Their Compositesmentioning

confidence: 99%

Carbon Nanostructures, Nanolayers, and Their Composites

2021

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The versatility of the arrangement of C atoms with the formation of different allotropes and phases has led to the discovery of several new structures with unique properties. Carbon nanomaterials are currently very attractive nanomaterials due to their unique physical, chemical, and biological properties. One of these is the development of superconductivity, for example, in graphite intercalated superconductors, single-walled carbon nanotubes, B-doped diamond, etc. Not only various forms of carbon materials but also carbon-related materials have aroused extraordinary theoretical and experimental interest. Hybrid carbon materials are good candidates for high current densities at low applied electric fields due to their negative electron affinity. The right combination of two different nanostructures, CNF or carbon nanotubes and nanoparticles, has led to some very interesting sensors with applications in electrochemical biosensors, biomolecules, and pharmaceutical compounds. Carbon materials have a number of unique properties. In order to increase their potential application and applicability in different industries and under different conditions, they are often combined with other types of material (most often polymers or metals). The resulting composite materials have significantly improved properties.

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“…The addition of nanodiamonds in HAp based coatings may also increase coating adhesion and prevent metal ion release from metal surfaces. Nanodiamonds have also been explored for their application in drug delivery applications [ 118 , 119 , 120 ].…”

Section: Carbon and Its Structuresmentioning

confidence: 99%

A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes

2018

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Biomedical materials constitute a vast scientific research field, which is devoted to producing medical devices which aid in enhancing human life. In this field, there is an enormous demand for long-lasting implants and bone substitutes that avoid rejection issues whilst providing favourable bioactivity, osteoconductivity and robust mechanical properties. Hydroxyapatite (HAp)-based biomaterials possess a close chemical resemblance to the mineral phase of bone, which give rise to their excellent biocompatibility, so allowing for them to serve the purpose of a bone-substituting and osteoconductive scaffold. The biodegradability of HAp is low (Ksp ≈ 6.62 × 10−126) as compared to other calcium phosphates materials, however they are known for their ability to develop bone-like apatite coatings on their surface for enhanced bone bonding. Despite its favourable bone regeneration properties, restrictions on the use of pure HAp ceramics in high load-bearing applications exist due to its inherently low mechanical properties (including low strength and fracture toughness, and poor wear resistance). Recent innovations in the field of bio-composites and nanoscience have reignited the investigation of utilising different carbonaceous materials for enhancing the mechanical properties of composites, including HAp-based bio-composites. Researchers have preferred carbonaceous materials with hydroxyapatite due to their inherent biocompatibility and good structural properties. It has been demonstrated that different structures of carbonaceous material can be used to improve the fracture toughness of HAp, as they can easily serve the purpose of being a second phase reinforcement, with the resulting composite still being a biocompatible material. Nanostructured carbonaceous structures, especially those in the form of fibres and sheets, were found to be very effective in increasing the fracture toughness values of HAp. Minor addition of CNTs (3 wt.%) has resulted in a more than 200% increase in fracture toughness of hydroxyapatite-nanorods/CNTs made using spark plasma sintering. This paper presents a current review of the research field of using different carbonaceous materials composited with hydroxyapatite with the intent being to produce high performance biomedically targeted materials.

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Nanodiamonds for drug delivery systems

Cited by 29 publications

References 67 publications

Combinatorial approaches to evaluate nanodiamond uptake and induced cellular fate

Combinatorial approaches to evaluate nanodiamond uptake and induced cellular fate

Carbon Nanostructures, Nanolayers, and Their Composites

A Review on the Use of Hydroxyapatite-Carbonaceous Structure Composites in Bone Replacement Materials for Strengthening Purposes

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