Nanodiamond-mediated drug delivery and imaging: challenges and opportunities

Vaijayanthimala, V.; Lee, Jaewoong; Kim, Sue V; Yen, Albert; Tsai, Nathaniel; Ho, Dean; Chang, Huan‐Cheng; Shenderova, Olga

doi:10.1517/17425247.2015.992412

Cited by 121 publications

(70 citation statements)

References 83 publications

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“…For that purpose chitosan porous particle [47], polymer [48] and lipid encapsulation [49] are usually used. Moreover, using nanoparticles, particularly ND, for targeted drug delivery expects increasing efficiency of the treatment [2,50] utilizing various mechanisms. Among the discussed mechanisms [18][19][20], different pathways of the internalization by cells and controlled release are considered.…”

Section: Resultsmentioning

confidence: 99%

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Spectral Analysis of Nanodiamond-Berberine Complex Interaction with Living Cells for Nanoparticle Mediated Drug Delivery

Lin¹,

Lin²,

Tsai³

et al. 2017

JBPE

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Abstract. The natural isoquinoline alkaloid berberine has been demonstrated for its significant activity against a variety of deceases caused by bacterial and parasite infections. Nanodiamond (ND) has also been proven to have great potential for drug delivery. In this work, the complex of ND with berberine is constructed through surface functionalized ND, aiming for drug delivery applications. Spectroscopic analysis was performed on the complex interaction with human lung alveolar carcinoma epithelial cell (A549) and red blood cell (RBC) in comparison with berberine in solution. The studied cells were treated with carboxylated ND, ND-berberine complex and berberine, respectively. Their distributions in cells structures are visualized using ND and berberine's fluorescence signals for detection. The distribution of ND and ND-berberine complex differs with the distribution of berberine introduced in solution form. The results show that the ND with attached drug molecules can act as a drug carrier allowing controllable localization of the drug into the cell. This result can have implication in drug delivery, release and delivery tracing applications. © 2017 Journal of Biomedical Photonics & Engineering.Keywords: Nanodiamond; Berberine; Bio-Applications; Medical Applications; Fluorescence; Surface Functionality; Imaging; Drug delivery; Nanobiotechnology. targeted nanoparticles as specific Helicobacter pylori eradication therapy: in vitro and in vivo study," Nanomedicine (Lond) 10(1), 57-71 (2015). 48. P. R. Vuddanda, A. Mishra, S. K. Singh, and S. Singh, "Development of polymeric nanoparticles with highly entrapped herbal hydrophilic drug using nanoprecipitation technique: an approach of quality by design," Pharm. Dev. Technol.

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Section: Resultsmentioning

confidence: 99%

“…Among the discussed mechanisms [18][19][20], different pathways of the internalization by cells and controlled release are considered. Thus, Iron oxide [50,51], gold [51], silica [52], graphene [53,54] NP have been suggested as berberine carrier. The enhanced anticancer efficiency of SiO2-berberine complex has been observed [52].…”

Section: Resultsmentioning

confidence: 99%

Spectral Analysis of Nanodiamond-Berberine Complex Interaction with Living Cells for Nanoparticle Mediated Drug Delivery

Lin¹,

Lin²,

Tsai³

et al. 2017

JBPE

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“…The factor was used to convert the diameters of individual particles to nm. A number of particles (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) were selected for each sample and the size distribution was determined.…”

Section: Particle Size Measurementmentioning

confidence: 99%

“…In addition, NDs are non-toxic [3], chemically and biologically inert [31] and biocompatible [28]. These characteristics of the NV -centre introduced within NDs make them suitable imaging tools for drug release carriers [32]. One of the most important characteristics of SF is the fact that it combines easily and can be optically activated with various dopants by simply dissolving them with SF such as aqueous suspension of NDs [25].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Khalid

Mitropoulos

Marelli

et al. 2015

Biomed. Opt. Express

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Nanoparticle (NP) based technologies have proved to be considerably beneficial for advances in biomedicine especially in the areas of disease detection, drug delivery and bioimaging. Over the last few decades, NPs have garnered interest for their exemplary impacts on the detection, treatment, and prevention of cancer. The full potential of these technologies are yet to be employed for clinical use. The ongoing research and development in this field demands single multifunctional composite materials that can be employed simultaneously for drug delivery and biomedical imaging. In this manuscript, a unique combination of silk fibroin (SF) and nanodiamonds (NDs) in the form of nanospheres are fabricated and investigated. The spheres were loaded with the anthracyline Doxorubicin (DoX) and the drug release kinetics for these ND-SF-DoX (NDSX) spheres were studied. NDs provided the fluorescence modality for imaging while the degradable SF spheres stabilized and released the drug in a controlled manner. The emission and structural properties of the spheres were characterized during drug release. The degradability of SF and the subsequent release of DoX from the spheres were monitored through fluorescence of NDs inside the spheres. This research demonstrates the enormous potential of the ND-SF nanocomposite platforms for diagnostic and therapeutic purposes, which are both important for pharmaceutical research and clinical settings. "Nanodiamond-mediated drug delivery and imaging: challenges and opportunities," Expert Opin. Drug Deliv. 12(5), 735-749 (2015).

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“…4 Of particular interest are carbon-based particles, such as nanodiamond particles (NDPs), which have been functionalized for diverse applications, 5 such as drug discovery, [6][7][8] drug delivery, 9,10 and imaging of pathological sites in vivo. 9,[11][12][13] More recently, special attention is focused on NDPs that can be excited optically to emit fluorescent light (F-NDPs) at various wavelengths, especially in the near infrared (NIR) range.…”

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confidence: 99%

Bitistatin-functionalized fluorescent nanodiamond particles specifically bind to purified human platelet integrin receptor α<sub>IIb</sub>β<sub>3</sub> and activated platelets

Marcinkiewicz¹,

Gerstenhaber²,

Sternberg³

et al. 2017

IJN

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Thromboembolic events (TEE) underwrite key causes of death in developed countries. While advanced imaging technologies such as computed tomography scans serve to diagnose blood clots during acute cardiovascular events, no such technology is available in routine primary care for TEE risk assessment. Here, we describe an imaging platform technology based on bioengineered fluorescent nanodiamond particles (F-NDPs) functionalized with bitistatin (Bit), a disintegrin that specifically binds to the α IIb β 3 integrin, platelet fibrinogen receptor (PFR) on activated platelets. Covalent linkage of purified Bit to F-NDP was concentration-dependent and saturable, as validated by enzyme-linked immunosorbent assay using specific anti-Bit antibodies. F-NDP–Bit interacted with purified PFR, either in immobilized or soluble form. Lotrafiban, a nonpeptide, α IIb β 3 receptor antagonist, specifically blocked F-NDP–Bit–PFR complex formation. Moreover, F-NDP–Bit specifically binds to activated platelets incorporated into a clot generated by thrombin-activated rat platelet-rich plasma (PRP). Our results suggest that engineered F-NDP–Bit particles could serve as noninvasive, “real-time” optical diagnostics for clots present in blood vessels.

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Nanodiamond-mediated drug delivery and imaging: challenges and opportunities

Cited by 121 publications

References 83 publications

Spectral Analysis of Nanodiamond-Berberine Complex Interaction with Living Cells for Nanoparticle Mediated Drug Delivery

Spectral Analysis of Nanodiamond-Berberine Complex Interaction with Living Cells for Nanoparticle Mediated Drug Delivery

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Bitistatin-functionalized fluorescent nanodiamond particles specifically bind to purified human platelet integrin receptor α<sub>IIb</sub>β<sub>3</sub> and activated platelets

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Nanodiamond-mediated drug delivery and imaging: challenges and opportunities

Cited by 121 publications

References 83 publications

Spectral Analysis of Nanodiamond-Berberine Complex Interaction with Living Cells for Nanoparticle Mediated Drug Delivery

Spectral Analysis of Nanodiamond-Berberine Complex Interaction with Living Cells for Nanoparticle Mediated Drug Delivery

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Bitistatin-functionalized fluorescent nanodiamond particles specifically bind to purified human platelet integrin receptor &alpha;<sub>IIb</sub>&beta;<sub>3</sub> and activated platelets

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Resources

About

Bitistatin-functionalized fluorescent nanodiamond particles specifically bind to purified human platelet integrin receptor α<sub>IIb</sub>β<sub>3</sub> and activated platelets