Nanodiamond mediated delivery of chemotherapeutic drugs

Li, Yingqi; Zhou, Xin; Wang, Dong‐Xin; Yang, Binsheng; Yang, Peng

doi:10.1039/c1jm10926j

Cited by 59 publications

(49 citation statements)

References 28 publications

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“…This work is an extension of our previous studies of ND-DOX in vitro, 30 in which we confirmed that ND-DOX has anticancer efficacy in vitro and shows slow and sustained drug release capability. It is important to determine if NDs can deliver a chemotherapeutic agent to solid tumors in animals via the enhanced permeability and retention effect.…”

Section: Introductionsupporting

confidence: 64%

“…Once in the tumor tissue, these ND-DOX will be internalized by tumor cells, largely via clathrin-dependent endocytosis ( Figure S2A), and will be located in the cytoplasm, where doxorubicin detached from FND-DOX could migrate and enter the nucleus to interact with DNA. 30 As seen in the …”

mentioning

confidence: 84%

“…30 In contrast, the uptake of doxorubicin occurs through an energyindependent passive diffusion mechanism. 30 A similar result was shown for FND-DOX in HepG2 cells ( Figure S3). …”

mentioning

confidence: 99%

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In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

Li¹,

Tong²,

Cao³

et al. 2014

IJN

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Background This study investigated the use of nanodiamond particles (NDs) as a promising material for drug delivery in vivo and in vitro. Methods HepG2 cells (a human hepatic carcinoma cell line) were used to determine the characteristics of a nanodiamond-doxorubicin complex (ND-DOX) when taken up by cells in vitro using laser scanning confocal microscopy and dialysis experiments. We also compared the survival rate and histopathology of tumor-bearing mice after treatment with NDs or ND-DOX in vivo. Results In vitro investigation showed that ND-DOX has slow and sustained drug release characteristics compared with free doxorubicin. In vivo, the survival rate of tumor-bearing mice treated with ND-DOX was four times greater than that of mice treated with free doxorubicin. Interestingly, the survival rate in mice treated with NDs alone was close to that of mice treated with free doxorubicin. This indicates that treatment with ND-DOX can prolong the lifespan of tumor-bearing mice significantly compared with conventional doxorubicin and that NDs can have this effect as well. Histopathological analysis showed that neither the NDs nor ND-DOX were toxic to the kidney, liver, or spleen in contrast with the well-known toxic effects of free doxorubicin on the kidney and liver. Further, both the bare NDs and ND-DOX could suppress tumor growth effectively. Conclusion NDs can potentially prolong survival, and ND-DOX may act as a nanodrug with promising chemotherapeutic efficacy and safety.

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Section: Introductionsupporting

confidence: 64%

mentioning

confidence: 84%

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In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles

Li¹,

Tong²,

Cao³

et al. 2014

IJN

Self Cite

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“…DOX can be bound to FNDs which, unlike DNDs, allow long-term fluorescence localization of particles within the cell. Li et al (2011b) showed that FND-DOX particles with diameters of *140 nm can be delivered inside HeLa cells efficiently via the clathrindependent endocytosis route with similar kinetics as non-adsorbed DOX.…”

Section: Small Moleculesmentioning

confidence: 96%

Nanodiamonds as Intracellular Probes for Imaging in Biology and Medicine

Šlegerová

Řehoř

Havlík

et al. 2014

Intracellular Delivery II

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In recent years, diamond nanoparticles have received a great deal of attention due to their unique photophysical and biological properties. Nanodiamonds (NDs) show low toxicity and are considered to be a highly biocompatible carbon nanomaterial useful in a wide range of applications. Thanks to their ability to accommodate nitrogen-vacancy (N-V) color centers, NDs are a prime example of non-photobleachable fluorescent labels and nanosensors. Here, we present a survey of ND applications in biology and medicine with an emphasis on bioimaging. We focus on distinguishing the properties of detonation NDs and highpressure high-temperature (HPHT) NDs and describing their physicochemical properties, structure and possible modifications by small molecules and biomolecules. We summarize and critically evaluate in vitro and in vivo data on ND toxicity and biocompatibility, cellular internalization, localization and targeting by surface-attached ligands. We discuss current achievements in bioimaging using fluorescent NDs and the potential of NDs in diagnostics and drug delivery.

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“…[7,8] These interesting properties make ND promising candidates for various biomedical applications. [5] It has been demonstrated that ND can be widely employed in biosensing [9,10], cell imaging [11][12][13][14], intracellular drug delivery [15][16][17][18][19] and so on. Results suggested that the fluorescent ND is a promising drug delivery carrier for intracellular tracking and delivery chemotherapeutic agents.…”

Section: Introductionmentioning

confidence: 99%