Nanodiamond delivery circumvents tumor resistance to doxorubicin

Wei, Xiao; Zhao, Yu; Lü, Xing

doi:10.1038/aps.2011.58

Cited by 21 publications

(14 citation statements)

References 12 publications

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“…The ioneelectron interaction is modeled by ultrasoft pseudopential in the Vanderbilt form [19]. Using these methods, satisfactory results have been received in other studies [20,21]. The valence atomic configurations are 3d 6 4s 2 for Fe, 3s 2 3p 1 for Al and 3s 2 3p 2 for Si atom.…”

Section: Calculation Model and Methodsmentioning

confidence: 92%

Electronic structure and magnetism of Fe3Al1−xSix alloys

Jiang

Bie

et al. 2010

Intermetallics

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Section: Calculation Model and Methodsmentioning

confidence: 92%

Electronic structure and magnetism of Fe3Al1−xSix alloys

Jiang

Bie

et al. 2010

Intermetallics

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“…Up to date, surgery, radiotherapy, and chemotherapy are still the three major cancer treatment approaches widely used in the clinic . However, current chemotherapy and radioisotope therapy (RIT) of cancer both suffer from the nonspecific distribution and low effective tumor uptake of therapeutic agents, severe side effects to normal tissues, as well as the development of multidrug resistance after a certain period of treatment . In the past few decades, nanomedicine that employs nanoparticles as drug delivery carriers to improve the pharmacokinetics and bioavailability of therapeutic agents, as well as to realize tumor‐targeted drug delivery, has received tremendous attention in both fundamental research and clinical practices .…”

Section: Introductionmentioning

confidence: 99%

Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer

Zhong

Yang

Dong

et al. 2015

Adv Funct Materials

230

172

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Development of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modifi cation with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as 99m Tc and 131 I, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with 99m Tc ( 99m Tc-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with 131 I and DOX ( 131 I-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment effi cacy in a remarkably synergistic manner, without rendering signifi cant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment.

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“…Up to now, chemotherapy, radiotherapy and surgery are still the three main cancer treatment methods widely used in clinic [4][5][6][7][8]. However, these traditional treatment approaches are limited to the low effective absorption of drugs, tumor multidrug resistance and serious side effects on normal tissues [9][10][11][12][13]. In the past few decades, nanomedicine, which employs nanoparticles as a versatile platform to load imaging agents with different types of therapeutic molecules, has realized image-guided joint cancer therapy with the optimized therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

A functionalized polydopamine theranostic nanoprobe for efficient imaging of miRNA-21 and in vivo synergetic cancer therapy

Mao

Zheng

Xie

et al. 2020

Preprint

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Background: MicroRNAs (miRNAs) are emerging as vital biomarkers since their abnormal expression is associated with various disease types including cancer. Therefore, it is essential to develop a sensitive and specific platform to monitor the dynamic expression of miRNAs for early clinical diagnosis and treatment. In this study, we designed a functionalized polydopamine (PDA)-based theranostic nanoprobe for efficient detection of miR-21 and in vivo synergistic cancer therapy.Methods: PDA was synthesized from dopamine hydrochloride and functionalized with polyethylene glycol (PEG). PDA-PEG nanoparticles were loaded with FITC-labeled hairpin DNA (hpDNA) and an anticancer drug doxorubicin (DOX). The measurement of miRNA-21 expression was reflected by the fluorescence quenching and release assay. The cellular toxicity of nanoprobe was assessed by Cell Counting Kit-8 (CCK-8) assay. Furthermore, the diagnosis and therapy effect of nanoparobe were investigated in xenograft tumor models.Results: PDA-PEG nanoparticles showed good stability in different solutions and effectively quench the fluorescence of FITC-labeled hpDNA. The presence of miR-21 induced the dissociation of hpDNA from PDA-PEG and subsequent the recovery of fluorescence signals. Upon cellular uptake of these nanoprobes, a dose-dependent fluorescence activation and synergetic cytotoxic effect were observed due to the release of DOX and inhibition of miR-21 function. Furthermore, PDA-PEG-DOX-hpDNA nanoparticles can afford long-term monitoring of miR-21 and combined therapeutic efficacy in the nude mice bearing 4T1 tumors.Conclusions: Our results demonstrate the capability of PDA-PEG-DOX-hpDNA as a theranostic nanoprobe for continuously tracking of miRNAs and synergetic cancer therapy.

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Nanodiamond delivery circumvents tumor resistance to doxorubicin

Cited by 21 publications

References 12 publications

Electronic structure and magnetism of Fe3Al1−xSix alloys

Electronic structure and magnetism of Fe3Al1−xSix alloys

Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer

A functionalized polydopamine theranostic nanoprobe for efficient imaging of miRNA-21 and in vivo synergetic cancer therapy

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