Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer

Zhong, Xiaoyan; Yang, Kai; Dong, Zhiliang; Yi, Xuan; Wang, Yong; Ge, Cuicui; Zhao, Yuliang; Liu, Zhuang

doi:10.1002/adfm.201503587

Cited by 238 publications

(183 citation statements)

References 57 publications

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“…131 I) with rather high efficiency via a standard chloramine-T oxidation method 22. Using a similar method, SWNT@PDA-PEG was labeled by 131 I by mixing with K 131 I and chloramine-T for 10 minutes, achieving a labeling yield as high as ~90% 22.…”

Section: Resultsmentioning

confidence: 99%

“…injection with SWNT@PDA-PEG/Mn (Figure 4b), suggesting the efficient tumor accumulation of those nanotubes. 131 I with gamma emission could offer contrast under single photon emission computed tomography (SEPCT) 22. Due to our limited access to small animal SPECT, gamma imaging was conducted as a proof-of-concept experiment to image 4T1 tumor-bearing mice after i.v.…”

Section: Resultsmentioning

confidence: 99%

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Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Zhao¹,

Chao²,

Liu³

et al. 2016

Theranostics

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113

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Single-walled carbon nanotubes (SWNTs) with various unique properties have attracted great attention in cancer theranostics. Herein, SWNTs are coated with a shell of polydopamine (PDA), which is further modified by polyethylene glycol (PEG). The PDA shell in the obtained SWNT@PDA-PEG could chelate Mn2+, which together with metallic nanoparticulate impurities anchored on SWNTs offer enhanced both T1 and T2 contrasts under magnetic resonance (MR) imaging. Meanwhile, also utilizing the PDA shell, radionuclide 131I could be easily labeled onto SWNT@PDA-PEG, enabling nuclear imaging and radioisotope cancer therapy. As revealed by MR & gamma imaging, efficient tumor accumulation of SWNT@PDA-131I-PEG is observed after systemic administration into mice. By further utilizing the strong near-infarared (NIR) absorbance of SWNTs, NIR-triggered photothermal therapy in combination with 131I-based radioisotope therapy is realized in our animal experiments, in which a remarkable synergistic antitumor therapeutic effect is observed compared to monotherapies. Our work not only presents a new type of theranostic nanoplatform based on SWNTs, but also suggests the promise of PDA coating as a general approach to modify nano-agents and endow them with highly integrated functionalities.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Zhao¹,

Chao²,

Liu³

et al. 2016

Theranostics

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113

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“…Moreover, albumin nanoparticles conjugated with folic acid and labeled with 131 I have also been used for tumor targeted enhanced RIT. [151,153,156] Due to the pH-dependent aqueous solubility, chitosan has also been employed for local RIT. [151,153] For example, polydopamine nanoparticles polymerized from dopamine with high biocompatibility could be labeled with both 99m Tc and 131 I for single photon emission computed tomography imaging (SPECT) of tumors and RIT cancer treatment with high efficacy.…”

Section: Organic and Polymeric Nanomaterials As Radioisotope Carriersmentioning

confidence: 99%

“…[212,213] Abraxane is an albumin based nanoparticles containing paclitaxel (130 nm) and has been clinically approved for the treatment of metastatic Albumin nanoparticles Paclitaxel [189][190][191] Poly(lactic-co-glycolic acid) nanoparitlces (PLGA) Paclitaxel, Etanidazole, 5-Fluorouracil, or NU7441 [124,[192][193][194][195][196] Cyclodextrin Camptothecin [188] Au nanoparticles Cisplatin or Trastuzumab [197][198][199] Mesoporous silica nanoparticles Cisplatin, Selenocystine, or Topotecan [200][201][202] UCNP-silica nanorattles Cisplatin or Docetaxel [57,61] Hollow or mesoporous TaOx nanoparticles 7-ethyl-10-hydroxycamptothecin or Doxorubicin [80,81] Chemo-RIT Liposomes 111 In -vinorelbine, 188 Re -doxorubicin, or 99 Y -paclitaxel [203][204][205][206][207] Polydopamine nanoparticles 131 I -Doxorubicin [156] Thermosensitive micelles 131 I -Doxorubicin [208] Albumin nanoparticles 131 I -Paclitaxel [150] Core-shell Bi 2 S 3 @mesoporous silica 32 P -Doxorubicin [67] www.advmat.de www.advancedsciencenews.com breast cancer. [212,213] Abraxane is an albumin based nanoparticles containing paclitaxel (130 nm) and has been clinically approved for the treatment of metastatic Albumin nanoparticles Paclitaxel [189][190]…”

Section: Polymeric Nanoparticles For Chemo-radiotherapymentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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“…Polydopamine (PDA) nanoparticles 18 have been proposed for use in a variety of biomedical applications in drug delivery, 19–21 cancer therapeutics, 22–24 antimicrobial applications, 25,26 bone and tissue engineering, 27–30 and cell adhesion and patterning. 31,32 Despite these in vitro demonstrations, most have failed to be translated successfully in vivo .…”

mentioning

confidence: 99%

Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications

et al. 2018

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Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse nanoparticles via autoxidation of serotonin monomers. To demonstrate potential applications of polyserotonin nanoparticles for cancer therapeutics, we show that these particles are biocompatible, exhibit photothermal effects when exposed to near-infrared radiation, and load the chemotherapeutic drug doxorubicin releasing it contextually and responsively in specific microenvironments. Quantum mechanical and molecular dynamics simulations were performed to interrogate the interactions between surface-adsorbed drug molecules and polyserotonin nanoparticles. To investigate the potential of polyserotonin nanoparticles for in vivo targeting, we explored their nano-bio interfaces by conducting protein corona experiments. Polyserotonin nanoparticles had reduced surface-protein interactions under biological conditions compared to polydopamine nanoparticles, a similar polymer material widely investigated for related applications. These findings suggest that serotonin-based nanoparticles have advantages as drug-delivery platforms for synergistic chemo- and photothermal therapy associated with limited nonspecific interactions.

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Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer

Cited by 238 publications

References 57 publications

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications

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