Nanodelivery system based on zein-alginate complexes enhances in vitro chemopreventive activity and bioavailability of pomelo [Citrus maxima (Burm.) Merr.] seed limonoids

Bautista, Gio Ferson M.; Vidallon, Mark Louis P.; Salamanez, Kevin C.; Rodriguez, Evelyn B.

doi:10.1016/j.jddst.2019.101296

Cited by 15 publications

(9 citation statements)

References 52 publications

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“…The release profile of WLYMs was determined according to dynamic dialysis methods, described previously. [21][22][23][24] An aqueous suspension of the microcapsules was placed in a dialysis bag (Sigma, 12 000 Da cut-off) suspended in sterile distilled water, which was continuously stirred. Each replicate sample was analyzed over a period of 24 h. At each time point during the analysis, an aliquot was removed and set aside for extraction.…”

Section: Release Profile Of the Wlymsmentioning

confidence: 99%

Encapsulation of wild oregano, Plectranthus amboinicus (Lour.) Spreng, phenolic extract in baker's yeast for the postharvest control of anthracnose in papaya

et al. 2022

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BACKGROUND Anthracnose caused by Colletotrichum gloeosporioides is considered as a major postharvest disease affecting many fruits. This plant disease is traditionally managed with synthetic fungicides, which are generally toxic and are linked to pathogen resistance. Recently, microencapsulated bioactives have been developed as potential alternative strategies to these methods, while utilizing natural fungicides and other phytochemicals. Wild oregano, Plectranthus amboinicus (Lour.) Spreng, contains potent antimicrobial phenolics, but these compounds are volatile and relatively unstable, which limits their efficacy during application. Herein, a baker's yeast microencapsulation system was applied to improve the stability of wild oregano phenolic extract (WOPE) and enhance its antifungal activity against anthracnose. RESULTS Encapsulation of WOPE in plasmolyzed yeast cells afforded a high encapsulation efficiency (93%) and yielded WOPE‐loaded yeast microcapsules (WLYMs) with an average diameter of 2.65 μm. Storage stability studies showed WLYMs are stable for at least 4 months. A 24 ‐h in vitro release experiment showed that WLYMs had an initial burst release upon redispersion in water, followed by a controlled release to about 80% of the loaded WOPE. Upon application as a spray‐type postharvest treatment for papaya, WLYMs exhibited a significantly improved mycelial inhibitory action against C. gloeosporioides and greatly reduced the anthracnose symptoms in papaya fruits. CONCLUSION This study presented a yeast microencapsulation system that can effectively stabilize WOPE and enhance its antifungal activity, making this microparticle formulation a promising environmentally safe postharvest treatment option to combat anthracnose symptoms in papaya fruits. © 2022 Society of Chemical Industry.

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Section: Release Profile Of the Wlymsmentioning

confidence: 99%

Encapsulation of wild oregano, Plectranthus amboinicus (Lour.) Spreng, phenolic extract in baker's yeast for the postharvest control of anthracnose in papaya

et al. 2022

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“…Simultaneously, this zein-alginate encapsulated LMN exhibited significantly improved glutathione S-transferase-inducing, free radical-scavenging, and antiangiogenic activity, indicating the potential of effective oral delivery system to enhance the bioavailability of LMN. 284 However, the relatively weak cytotoxic potency of LMN seems to limit its potential drug use, and thus, SAR-guided synthetic modification may facilitate the development of its modified derivatives as useful cancer chemotherapeutic agents. SAR investigations for different types of limonoids and their potential antitumor activity have been reviewed recently in 2018, and both the furan ring and substitution at the C-7 position were found to be required for LMN to induce phase II detoxification enzymes.…”

Section: ■ Triterpene Lactonesmentioning

confidence: 99%

“…The release of LMN in simulated gastric fluid, and, preferentially, in simulated intestinal fluid, was delayed and minimized by this nanodelivery system. Simultaneously, this zein-alginate encapsulated LMN exhibited significantly improved glutathione S -transferase-inducing, free radical-scavenging, and antiangiogenic activity, indicating the potential of effective oral delivery system to enhance the bioavailability of LMN . However, the relatively weak cytotoxic potency of LMN seems to limit its potential drug use, and thus, SAR-guided synthetic modification may facilitate the development of its modified derivatives as useful cancer chemotherapeutic agents.…”

Section: Triterpene Lactonesmentioning

confidence: 99%

Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones

Ren

Kinghorn

2020

J. Med. Chem.

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Naturally occurring terpenoid lactones and their synthetic derivatives have attracted increasing interest for their promising antitumor activity and potential utilization in the discovery and design of new antitumor agents. In the present perspective article, selected plant-derived five-membered γ-lactones and six-membered δ-lactones that occur with terpenoid scaffolds are reviewed, with their structures, cancer cell line cytotoxicity and in vivo antitumor activity, structure–activity relationships, mechanism of action, and the potential for developing cancer chemotherapeutic agents discussed in each case. The compounds presented include artemisinin (ART, 1), parthenolide (PTL, 2), thapsigargin (TPG, 3), andrographolide (AGL, 4), ginkgolide B (GKL B, 5), jolkinolide B (JKL B, 6), nagilactone E (NGL E, 7), triptolide (TPL, 8), bruceantin (BRC, 9), dichapetalin A (DCT A, 10), and limonin (LMN, 11), and their naturally occurring analogues and synthetic derivatives. It is hoped that this contribution will be supportive of the future development of additional efficacious anticancer agents derived from natural products.

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“…Alginate Lee et al, 2016;Bautista et al, 2019) Antisolvent precipitation Or pH-induced antisolvent precipitation Spherical core-shell Limonoids SOD…”

Section: Concise Reviews and Hypotheses In Food Sciencementioning

confidence: 99%

“…obtained similar results on limonoids encapsulated in ZANs. ZANs enhanced the limonoids encapsulation efficiency and stability, improved their activities, and controlled their release in GIT (Bautista, Vidallon, Salamanez, & Rodriguez, 2019).…”

Section: Development Of Zein/polysaccharide Nanoparticlesmentioning

confidence: 99%

Development of a nanoparticle delivery system based on zein/polysaccharide complexes

2020

Journal of Food Science

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Zein, an alcohol-soluble protein in corn, can self-assemble into spherical nanoparticles, which makes it an ideal carrier material for the encapsulation of hydrophobic bioactive molecules. However, zein nanoparticles easily aggregate in water and are sensitive to enzymatic degradation in the digestive system. A strategy to overcome their limitations is the incorporation of polysaccharides as a second polymer layer that provides stability to zein nanoparticles. This review introduces the characteristics of zein as they relate to understanding the formation of zein/polysaccharide nanoparticles. Particular attention is paid to the preparation methods for the zein/polysaccharide nanoparticles, as well as to the morphological observation methods and detection mechanism. Moreover, the properties and applications of zein/polysaccharide nanoparticles are highlighted.

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Nanodelivery system based on zein-alginate complexes enhances in vitro chemopreventive activity and bioavailability of pomelo [Citrus maxima (Burm.) Merr.] seed limonoids

Cited by 15 publications

References 52 publications

Encapsulation of wild oregano, Plectranthus amboinicus (Lour.) Spreng, phenolic extract in baker's yeast for the postharvest control of anthracnose in papaya

Encapsulation of wild oregano, Plectranthus amboinicus (Lour.) Spreng, phenolic extract in baker's yeast for the postharvest control of anthracnose in papaya

Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones

Development of a nanoparticle delivery system based on zein/polysaccharide complexes

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