Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering

Das, Biswajit; Chattopadhyay, Pronobesh; Mishra, Debasish; Maiti, Tapas K.; Maji, Somnath; Narayan, Rajan; Karak, Niranjan

doi:10.1039/c3tb20693a

Cited by 41 publications

(44 citation statements)

References 33 publications

(38 reference statements)

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“…It is well‐known that properties such as stiffness, strength, thermal and electrical conductivity can be improved by addition of low amounts of nanofillers such as nanoclays, cellulose nanocrystals, graphene, graphene oxide (GO), and carbon nanotubes (CNTs) …”

Section: Introductionmentioning

confidence: 99%

Synthesis of CNT‐polyurethane nanocomposites using ester‐based polyols with different molecular structure: Mechanical, thermal, and electrical properties

Shamsi

Mahyari

Koosha

2016

J of Applied Polymer Sci

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Polyurethanes (PUs) were prepared by in situ polymerization of three diisocyanate with three synthesized low cost esterbased polyols. The effect of diisocyanate type, diol structure, and molar ratio of diisocyanate to polyol on the mechanical properties was examined and the optimum chemical structure was introduced regarding the superior mechanical properties. Also, in presence of well dispersed hydroxylated multiwalled carbon nanotubes (CNT), PU/CNT nanocomposites were synthesized and fully characterized. The results showed that PU synthesized based on 1,4-butane diol (BDO) has the best mechanical properties and thermal stability. Also, the PU samples synthesized from 1,6-hexamethylene diisocyanate (HDI) were more profitable than aromatic diisocyanate structures due to higher crystallinity and microstructure packing. The nanocomposite sample containing 1.5% CNT was the optimum composition for the maximum tensile strength and electrical conductivity. This result was related to the uniform dispersion and bonding of CNTs to PU chains at this composition, while aggregates were formed at higher concentration of CNTs which increased the defects and reduced the uniformity of the structure.

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Section: Introductionmentioning

confidence: 99%

Synthesis of CNT‐polyurethane nanocomposites using ester‐based polyols with different molecular structure: Mechanical, thermal, and electrical properties

Shamsi

Mahyari

Koosha

2016

J of Applied Polymer Sci

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“…MMT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay is also confirmed the cytotoxicity. A good number of bio-based hyperbranched polyurethanes and their nanocomposites with different nanomaterials are tested for biocompatibility by the author's group and found almost all such materials showing positive results (61,71,73 …”

Section: Biocompatibility and Antibacterial Propertiesmentioning

confidence: 99%

“…In vitro biodegradation into nontoxic by-products, cytocompatibility, immunocompatibility, hemocompatibility, as well as histocompatibility and supporting of adherence and proliferation of cells proved potentiality of bio-based hyperbranched polyurethanes as scaffolds in the niche of tissue engineering preferentially as an artificial skin or as a cardiovascular implant (80). Sunflower oil-modified polyol-based hyperbranched polyurethane nanocomposites with Fe 3 O 4 nanoparticles, functionalized MWCNT, and their nanohybrid with tunable biodegradability and favorable other desired biological attributes are reported to be utilized in biomedical implants and tissue engineering (61,71,73). These nanocomposite-based scaffolds showed nontoxic behavior with good cytocompatibility and have the potential to be applied to repairing the 32 BIO-BASED HYPERBRANCHED POLYURETHANE NANOCOMPOSITES damaged bone cells.…”

mentioning

confidence: 96%

“…However, the structure and molecular weight of the hyperbranched polyurethane ultimately control the biodegradation. Furthermore, biodegradability of such polyurethanes is improved significantly on the formation of suitable nanocomposites (58,61,71,73,74). This improvement in biodegradability is mainly due to catalytic role of the nanomaterials in the biodegradation mechanism.…”

mentioning

confidence: 99%

“…The porous castor oil-based polyurethanes and their nanocomposites are found to be biocompatible (73,80). The cytocompatibility of such nanocomposites is evaluated by in vitro cell culture as well as in vivo study, and no negative effect on the cell morphology, viability, proliferation, and differentiation is observed, which reveals the good cellular affinity and cytocompatibility of such nanocomposites (61,71,73). MMT (3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay is also confirmed the cytotoxicity.…”

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confidence: 99%

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Bio‐Based Hyperbranched Polyurethane Nanocomposites

Karak

2015

Encyclopedia of Polymer Science and Technology

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BIO-BASED HYPERBRANCHED POLYURETHANE NANOCOMPOSITESadjusting the ratio of isocyanate (-NCO) to hydroxyl (-OH) functionality and the chemical composition in the final structure of the polyurethane, different types of polymeric products like thermosetting resin and elastomer as well as thermoplastic and fiber can be obtained (3). In all such polyurethanes, the main linkage, urethane (-NH-C(=O) -O-) is a unique combination of rigid amide (-NH-C=O), which has a tendency to donate proton, and a flexible ester (-O-C=O) group, which has a tendency to accept proton. Further flexibility arises from the flexible soft segment and long hydrocarbon part of fatty acid chains of the vegetable oil component present in the bio-based segmented polyurethanes. Moreover, they are biodegradable and biocompatible. All these unique features of bio-based polyurethanes widen their applications in the domains of coating, paint, adhesive, sealant, composite, biomaterial, smart material, and so on.Again, incorporation of branching in the polymer structure greatly influences the processing and properties of the branched polymer. Thus hyperbranched polymers are treated as macromolecules for 21st century. These hyperbranched polymers are one type of dendritic polymers ( Fig. 1), where the other type is a perfectly regular structure with a three-dimensional architecture, known as a dendrimer (4). However, hyperbranched polymers are preferred in most of the industrial applications over multistep laborious synthesized dendrimers because of easier and simpler one-step synthetic protocol of the former as they can accommodate some defects in their structures. Thus mass-scale industrial production at relatively low cost is possible for hyperbranched polymers like conventional linear polymers. However, hyperbranched polymers enjoy many advantages over linear polymers (Fig. 1). These include a unique three-dimensional structural architecture with dendritic, linear, and terminal units, the presence of a large number of freely exposed surface groups, low polydispersity index, low viscosity, high solubility, high compatibility with other materials, etc. Therefore, bio-based hyperbranched polyurethanes are preferred as superior materials over their conventional analogs for different advanced applications.However, "virginity is not a virtue" in case of polymer, whatsoever the structural architecture is! Thus bio-based hyperbranched polyurethanes also require to be adulterated by incorporation of appropriate additives or ingredients. It is pertinent to mention here that most of the vegetable oil-based hyperbranched polyurethanes do not have required mechanical strength and toughness, although they possess very good flexibility. In this vein, conventional filled and composite systems are widely used, although both the approaches suffer from serious drawbacks, as a huge amount of additive(s) is necessary to be incorporated to achieve the desired level of performance of the stated polyurethanes. Most importantly, the resultant products lost most of the central a...

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Polymer‐Carbon Nanotube Nanocomposite Foams

Antunes¹,

Velasco²

2014

Polymer Nanotube Nanocomposites

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Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering

Cited by 41 publications

References 33 publications

Synthesis of CNT‐polyurethane nanocomposites using ester‐based polyols with different molecular structure: Mechanical, thermal, and electrical properties

Synthesis of CNT‐polyurethane nanocomposites using ester‐based polyols with different molecular structure: Mechanical, thermal, and electrical properties

Bio‐Based Hyperbranched Polyurethane Nanocomposites

Polymer‐Carbon Nanotube Nanocomposite Foams

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