Nanocomposites based on graphene oxide and mesoporous silica nanoparticles: Preparation, characterization and nanobiointeractions with red blood cells and human plasma proteins

Understanding the driving forces of camptothecin interactions on the surface of nanocomposites based on graphene oxide decorated with silica nanoparticles

“…4(C) shows a TEM image of the GO-MSN 10 + CPT system, revealing graphene oxide sheets in the micrometric domain decorated with silica nanoparticles (indicated by red arrows); the system retains the structural integrity of the used raw material (GO-MSN 10 ) discussed in our previous work. 30 The image also shows needle-shaped camptothecin crystals with similar dimensions to the GO + CPT system and corroborates the mentioned intermolecular association between camptothecin molecules. The presented set of characterization techniques conrms the preparation of mesoporous silica nanoparticles, graphene oxide and nanocomposite GO-MSN 10 that contain encapsulated camptothecin.…”

“…In addition, the GO-MSN 10 nanomaterial presents signicantly reduced haemolysis rates relative to those of graphene oxide, according to our previously published work. 30 From a physicochemical point of view, the fast release of camptothecin from silica nanoparticles has its origins in the weak interaction of this drug with phenyl groups present inside the pores (see Fig. 5(A)), which explains the low encapsulation capacity of this nanomaterial compared to that of the other nanocarriers.…”

“…Studies related to GO materials comprising CPT as a drug host molecule are still rare and show promising results from the point of view of high encapsulation capacity. 34,35 However, the literature has reported toxic effects of GO, such as cell membrane damage and a high capacity to cause haemolysis, 30,36 thus increasing the chance of toxicity in intravenous applications. There are also studies that show opposite effects, characterized by a low haemolytic effect.…”

Thin Electric Heating Membrane Constructed with a Three-Dimensional Nanofibrillated Cellulose–Graphene–Graphene Oxide System

“…Furthermore, the stability of these dispersion can be directly appraised by the zeta potential [ 22 ], which was measured as −46.8, −42.7, and −37.9 mV, respectively ( Figure S3, Supplementary Materials ). NFC and GO particles presented a negative charge in the water dispersion [ 23 , 24 , 25 ], giving the NFC-GO mixture negative charge that facilitated a stable homodispersion due to repulsion between particles with the same negative charge; of which, GO sheets exhibit negative zeta potential values mainly due to the presence of hydroxyl (O−) and carboxylic acid (COO−) groups on their surface [ 25 ]. Consequently, a stable NFC-graphene-GO dispersion was obtained.…”

Sorption of cesium and cobalt ions onto novel zirconium silicophosphate/polyacrylamide nanocomposite

“…Polyacrylamide (PAA) constitutes a familiar polymer to be used in the synthesis of such composites among the other organics. Based on the co-part with PAA, the produced nanocomposites may have catalytic (Abou El Fadl, 2016;Mahdavi & Rahmani, 2016), antibacterial (Hussain & Jaisankar, 2017;Li et al, 2013;Mahdavi, Rahmani, & Shahverdi, 2017), biointeractional (Fonseca, 2018) and enhanced oil recovery (Singh & Mahto, 2017) applications. Additionally, the majority of authors utilized the PAA-based nanocomposites in adsorption applications like water purification (Atta, Al-Lohedan, Ezzat, Issa, & Oumi, 2016;Manafi et al, 2017) as well as removal of dyes (Hadizade, Binaeian, & Emami, 2017;Zhou, Wu, Lei, & Negulescu, 2014), Hg (II) (Hosseinzadeh & Ramin, 2016;Saad et al, 2016), lead (II) (Güçlü et al, 2010;Xu et al, 2014), Fe (III) (Natkański, Kuśtrowski, Białas, Piwowarska, & Michalik, 2013), Cu (II) (Güçlü et al, 2010), and moisture (Mirbagheri & Hill, 2017).…”