Nanocomposite powders of hydroxyapatite-graphene oxide for biological applications

Lopes, Camila Cristine; Pinheiro, Wagner Anacleto; Rocha, Daniel Navarro da; Neves, José Guilherme; Correr, Américo Bortolazzo; Ferreira, José Ricardo Muniz; Barbosa, Rafael Maza; Soares, Jefferson R.F.; Santos, Jheison Lopes dos; Silva, Marcelo Henrique Prado da

doi:10.1016/j.ceramint.2020.11.107

Cited by 22 publications

(32 citation statements)

References 53 publications

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“…CaP and CaPGO particles, characterized by means of FT-IR spectroscopy and X-Ray Diffraction ( Figure S4 ), were found to be composed of a mixture of brushite, monetite, hydroxyapatite and other calcium phosphates (e.g., calcium pyrophosphate). Despite the greyish appearance of the CaPGO powders ( Figure S4a ), the typical FT-IR and XRD signals of graphene oxide cannot be clearly detected due to the low mass ratio and the overlapping with the phosphate groups ( Figure S4b,d ), as described in the literature [ 32 ].…”

Section: Resultsmentioning

confidence: 71%

“…In these cases, the presence of HA can be observed even after the first time point (7 days). Interestingly, the HA peaks at 2θ 31.8°, 32.2°, 32.9° and 34.0° appear as a single, broad and poorly defined peak suggesting the nanometric dimensions of the hydroxyapatite crystallite [ 32 ]. In order to remove the interference of NaCl and Tris and to verify that HA crystals are tightly embedded in the TOCNFs matrix, after 28 days the hydrogels were rinsed in pure water and the XRD measurements were repeated ( Figure 5 d).…”

Section: Resultsmentioning

confidence: 99%

“…However, in the diffractograms of TOCNFs CaP (Figure 5b) and TOCNFs CaPGO (Figure 5c) samples it was possible to identify the typical diffraction pattern of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) at 10. [32]. In these cases, the presence of HA can be observed even after the first time point (7 days).…”

Section: In Vitro Mineralization Testmentioning

confidence: 88%

“…XRD patterns for each sample at all the time points are reported in Figure 5a-c In case of TOCNFs samples (Figure 5a) no evidence of apatite formation can be observed. However, in the diffractograms of TOCNFs CaP (Figure 5b) and TOCNFs CaPGO (Figure 5c) samples it was possible to identify the typical diffraction pattern of hydroxyapatite (Ca10(PO4)6(OH)2, HA) at 10.6°, 25.9°, 28.3°, 31.8°, 32.8°, 34.0°, 39.6°, 46.7°, 49.5° and 53.2° [32]. In these cases, the presence of HA can be observed even after the first time point (7 days).…”

Section: In Vitro Mineralization Testmentioning

confidence: 99%

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Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

et al. 2021

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Cellulose represents a low cost, abundant, and renewable polysaccharide with great versatility; it has a hierarchical structure composed of nanofibers with high aspect ratio (3–4 nm wide, hundreds of μm long). TEMPO-mediated oxidation represents one of the most diffused methods to obtain cellulose nanofibers (CNFs): It is possible to obtain physically crosslinked hydrogels by means of divalent cation addition. The presence of inorganic components, such as calcium phosphates (CaP), can improve not only their mechanical properties but also the bioactivity of the gels. The aim of this work is to design and characterize a TEMPO-oxidized cellulose nanofibers (TOCNFs) injectable hydrogel embedded with inorganic particles, CaP and CaP-GO, for bone tissue regeneration. Inorganic particles act as physical crosslinkers, as proven by rheological characterization, which reported an increase in mechanical properties. The average load value registered in injection tests was in the range of 1.5–4.4 N, far below 30 N, considered a reasonable injection force upper limit. Samples were stable for up to 28 days and both CaP and CaP-GO accelerate mineralization as suggested by SEM and XRD analysis. No cytotoxic effects were shown on SAOS-2 cells cultured with eluates. This work demonstrated that the physicochemical properties of TOCNFs-based dispersions could be enhanced and modulated through the addition of the inorganic phases, maintaining the injectability and bioactivity of the hydrogels.

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Section: Resultsmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: In Vitro Mineralization Testmentioning

confidence: 88%

Section: In Vitro Mineralization Testmentioning

confidence: 99%

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Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

et al. 2021

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“…After laser treatment, the composite had surface macropores with diameters from 200 µm to 600 µm, which improved cell adhesion and proliferation of constant cells and thus overall biocompatibility and utilization [144]. Lopes et al [145] prepared HA-GO NCPs with the addition of 0.5 wt%, 1.0 wt%, and 1.5 wt% of GO. HA NPs were adhered to the surface of the GO sheets, and the affinity between HA and GO increased from 0.5 wt% to 1.5 wt% GO in the HA-GO NCPs.…”

Section: Graphene-based Materialsmentioning

confidence: 99%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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The potential of nano graphene oxide and chlorhexidine composite membranes for use as a surface layer in functionally graded membranes for periodontal lesions

Qasim,

Ahmed,

Karched

et al. 2023

J Mater Sci: Mater Med

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Membranes have been used for treating periodontal defects and play a crucial role in guided bone regeneration applications. Nano graphene oxide have been exploited in tissue engineering due to its biomechanical properties. Its composite formulations with hydroxyapatite and chitosan with controlled degradation could aid in becoming part of a surface layer in a functionally graded membrane. The aim of the study was to synthesize chitosan and composite formulations of nano graphene oxide, hydroxyapatite and chlorhexidine digluconate using solvent casting technique and to characterize the physiochemical, mechanical, water vapor transmission rate (barrier), degradation and antimicrobial potential of the membranes. Altogether four different membranes were prepared (CH, CCG, 3511 and 3322). Results revealed the chemical interactions of hydroxyapatite, chitosan and nanographene oxide due to inter and intra molecular hydrogen bonding. The tensile strength of 3322 (33.72 ± 6.3 MPa) and 3511 (32.06 ± 5.4 MPa) was higher than CH (27.46 ± 9.6 MPa). CCG showed the lowest water vapor transmission rate (0.23 ± 0.01 g/h.m2) but the highest weight loss at day 14 (76.6 %). 3511 showed a higher drug release after 72 h (55.6 %) Significant biofilm growth inhibition was observed for all membranes. 3511 showed complete inhibition against A. actinomycetemcomitans. Detailed characterization of the synthesized membranes revealed that 3511 composite membrane proved to be a promising candidate for use as a surface layer of membranes for guided bone regeneration of periodontal lesions. Graphical Abstract

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Nanocomposite powders of hydroxyapatite-graphene oxide for biological applications

Cited by 22 publications

References 53 publications

Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

The potential of nano graphene oxide and chlorhexidine composite membranes for use as a surface layer in functionally graded membranes for periodontal lesions

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