Nanocomposite coatings for implants protection from microbial colonization: Formation features, structure, and properties

Chen, Qi; Rogachev, А.V.; Тапальский, Д. В.; Yarmolenko, М.А.; Jiang, Xiaohong; Koshanskaya, E.V.; Воронцов, А. А.

doi:10.1016/j.surfcoat.2017.02.066

Cited by 17 publications

(5 citation statements)

References 20 publications

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“…Использовали фрагменты спиц для остеосинтеза диаметром 1 мм и длиной 20 мм из корозионностойкой стали аустенитного класса (Научно-технологический парк БНТУ «Политехник», Беларусь, ТУ РБ 14576608.002-2000). Четырехкомпонентное композиционное антимикробное покрытие на основе полиуретана, полилактида, ципрофоксацина и наночастиц серебра наносили вакуумно-плазменным методом из активной газовой фазы [10,12]. Контрольные имплантаты не имели покрытия на своей поверхности.…”

Section: материал и методы имплантатыunclassified

“…С использованием клеточных культур HEp-2, HaCaT и первичной культуры фибробластов сделано заключение о биосовместимости четырехкомпонентного антибактериального покрытия полиуретан-полилактид-ципрофлоксацин-хло-рид серебра и отсутствии у него цитотоксичности. Исследование местного действия после имплантации нелинейным крысам показало, что титановые имплантаты с композиционным антибактериальным покрытием обладают большей биосовместимостью и лучшей биоинтеграцией в окружающую соединительную ткань по сравнению с имплантатами без покрытий [12,13].…”

Section: Introductionunclassified

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Perifocal Soft Tissue Reactions in Response to Contaminated Implants With a Composite Antibacterial Coating: Experimental Study

Savchuk

Tapalski

Зиновкин

et al. 2023

Traumatology and Orthopedics of Russia

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Background. Protection against microbial colonization of surface fixators for osteosynthesis reduces the number of infectious complications. The aim of the study was to assess the biological compatibility of implants with a composite antibacterial coating under microbial load. Methods. Fragments of steel carpal pins with four-component antimicrobial coating based on polylactide, polyurethane, ciprofloxacin and silver nanoparticles were contaminated by methicillin resistant Staphylococcus aureus. They were implanted in rats within the quadriceps femoris. Contaminated uncoated pins were used as a control. The animals were withdrawn from the experiment on the 2nd, 4th, 7th day after implantation. Pathohistological tissue specimens of the periimplantation zone were prepared. A semiquantitative assessment of periimplantation tissue reactions was performed. Results. The microbial load was (1,120,26)*106 S. aureus cells for the control implants and (0,860,31)*106 cells for implants with antibacterial coating. Tissue inflammatory reactions on the second day of implantation were equally evident in the control and investigated groups. There was a significant reduction in the number of immune cells and necrotic detritus, as well as increased growth of connective tissue and neoangiogenesis in the experimental group by the 4th day. The appearance of a less pronounced well-vascularized fibrous capsule around the experimental implants was noted by the 7th day. It indicates a more favorable healing of soft tissues in comparison with the control. Conclusions. Weak morphological manifestations of tissue reactions in response to the fitting of contaminated implants with an antibacterial coating can be associated with both the direct antimicrobial effect of the coating components and the anti-inflammatory activity of silver nanoparticles and ciprofloxacin included in its composition. Keywords: implants, antibacterial coating, ciprofloxacin, silver nanoparticles, Staphylococcus aureus, contamination, tissue reactions.

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Section: материал и методы имплантатыunclassified

Section: Introductionunclassified

Perifocal Soft Tissue Reactions in Response to Contaminated Implants With a Composite Antibacterial Coating: Experimental Study

Savchuk

Tapalski

Зиновкин

et al. 2023

Traumatology and Orthopedics of Russia

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“…Na Figura 5 está apresentada a estrutura da vancomicina. A grande problemática que vem sendo exposta é a questão da resistência bacteriana a vários antibióticos (Cox et al, 2016;Qi et al, 2017), sobretudo quando a administração é via oral. Assim, uma solução bastante atraente que o campo da ortopedia tem focado para minimizar ou evitar a adesão microbiana, evitando desta forma os casos de infecções, são as superfícies antibacterianas a base de hidrogéis de quitosana, que podem de forma preventiva evitar que as bactérias entrem em contato com a superfície do implante .…”

Section: Vancomicinaunclassified

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

2022

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da UFCG. Atua no desenvolvimento de novos materiais via síntese química, atividades relacionadas à nanotecnologia e desenvolvimento de materiais para aplicação em eletro-eletrônica, catálise, materiais magnéticos, ópticos, nanocompósitos, biomateriais, membranas cerâmicas e marcadores biológicos. Possui experiência em síntese e caracterização de materiais, desenvolvimento de materiais magnéticos para aplicações em catálise, absorvedores de radiação eletromagnética, marcadores biológicos e dispositivos magnéticos moles. Participa como membro permanente do Programa de Pós-Graduação em Ciências e Engenharia de Materiais (conceito CAPES 5). Também atua na formação de recursos humanos participando ativamente dos programas de

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“…Therefore, new strategies in the field of orthopedics have focused mainly on limiting the initial preoperative (Cai et al, 2017) and postoperative (Birt et al, 2017) microbial adhesion to the surfaces of the implants, for this patient are submitted to the use of antibiotics (Kapadia et al, 2016). However, many types of bacteria develop resistance to various antibiotics (Cox et al, 2016;Qi et al, 2017), especially when administered orally. Thus, a very attractive solution to minimize the use of antibiotics are bactericidal surfaces that can preventively kill bacteria in contact with the implant surface, protecting the site or releasing the antimicrobial agent and protecting the implant surface (Raphel et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses

Nepomuceno

Dias

Araújo

et al. 2022

RSD

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Chitosan hydrogels stand out for being an adhesive matrix, which presents biocompatibility, antibacterial and osteogenic properties, biodegradability, non-toxicity, capable of retaining, releasing, and distributing therapeutic agents (drugs) at the application site. Therefore, new strategies in the field of orthopedics have focused, above all, on limiting the initial preoperative and postoperative microbial adhesion to implant surfaces, modifying these surfaces, protecting them from eventual adhesions or releasing the antimicrobial agent. The production of chitosan-based hydrogels has been achieved through physical and chemical cross-linking routes. In this context, this research aimed to develop an antibacterial hydrogel based on chitosan and vancomycin for application in total knee arthroplasty and to prevent bacterial infections. For that, three crosslinking procedures of chitosan with genipin were investigated to obtain the hydrogels and drug delivery. For this purpose, initially, the raw materials chitosan, genipin and vancomycin were characterized by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), pHmetry (pH) and microbiological tests. From the chemical crosslinking procedures evaluated, the drug release was investigated, and the hydrogels were characterized by FTIR, pH, viscosity, microbiology, and cytotoxicity. A new H5Q1GV hydrogel was obtained with good antibacterial activity, potentiated by the acidity of its pH 5.7, which showed good drug release in the first 4 hours after implantation, homogeneous, with ideal viscosity and adhesion for application through syringes in prosthesis surgery. knee and with excellent biocompatibility.

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Nanocomposite coatings for implants protection from microbial colonization: Formation features, structure, and properties

Cited by 17 publications

References 20 publications

Perifocal Soft Tissue Reactions in Response to Contaminated Implants With a Composite Antibacterial Coating: Experimental Study

Perifocal Soft Tissue Reactions in Response to Contaminated Implants With a Composite Antibacterial Coating: Experimental Study

Novas tecnologias aplicadas à engenharia biomédica: Uma Contribuição à Engenharia de Tecidos

Chitosan/vancomycin antibacterial hydrogel for application in knee prostheses

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