Nanocomposite bioinks for 3D bioprinting

Cai, Yanli; Chang, Soon Yee; Gan, Soo Wah; Ma, Sha; Lu, Wen Feng; Yen, Ching Chiuan

doi:10.1016/j.actbio.2022.08.014

Cited by 41 publications

(34 citation statements)

References 132 publications

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“…In addition, with the continuous improvement of hydrogel preparation technology, some advanced hydrogel preparation strategies, such as 3D bioprinting technology, microfluidic technology, and micro/nanogels have been developed and summarized in recent studies. [26,29,166,167] However, traditional hydrogel preparation methods are mostly adopted in the present Exo-Gel system. In subsequent studies, the advanced methods mentioned above can be combined with the Exo-Gel system to exert the effect of a powerful combination.…”

Section: Conclusion and Further Perspectivesmentioning

confidence: 99%

Exosome‐Hydrogel System in Bone Tissue Engineering: A Promising Therapeutic Strategy

Wang

Zhu

et al. 2023

Macromolecular Bioscience

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Exosomes, as messengers of cell-to-cell communication, have many functional properties similar to those of their derived cells. Because they contain a large number of bioactive components that regulate recipient cell behavior, they are inanimate and do not require external maintenance or assistance. Various cell-derived exosomes are involved in many physiological processes of bone tissue repair. Hydrogels are widely used as scaffolding materials for bone tissue repair because their 3D network structure resembles the natural extracellular matrix. Moreover, their material properties and biological functions are adjustable. Exosomes can be delivered directly to the bone tissue damage site by hydrogel, and their duration of action in vivo can be prolonged by slow release. Therefore, the exosome-loaded hydrogel (Exo-Gel) system is a promising material for bone tissue engineering. In this study, the progress of the application of Exo-Gel in bone tissue repair and the improvement strategies, problems and research prospects of the current exosomes and hydrogels that have been applied to the Exo-Gel system for bone tissue repair are reviewed.

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Section: Conclusion and Further Perspectivesmentioning

confidence: 99%

Exosome‐Hydrogel System in Bone Tissue Engineering: A Promising Therapeutic Strategy

Wang

Zhu

et al. 2023

Macromolecular Bioscience

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“…The aim of 3D bioprinting is to produce 3D scaffolds that can mimic the composition, architecture, and mechanical properties of native tissues as well as regen-erate functional tissues and support cell-ECM interactions [129]. The incorporation of clay nanoparticles has been shown to efficiently improve the development of nanoengineered bioinks [130], enhancing their flow behavior, shape recovery, and biological activity (Table 6) [131].…”

Section: D Bio Printingmentioning

confidence: 99%

“…ate functional tissues and support cell-ECM interactions [129]. The incorporation of clay nanoparticles has been shown to efficiently improve the development of nanoengineered bioinks [130], enhancing their flow behavior, shape recovery, and biological activity (Table 6) [131].…”

Section: Ha + Pegda Laponitementioning

confidence: 99%

Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review

et al. 2022

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In recent decades, new and improved materials have been developed with a significant interest in three-dimensional (3D) scaffolds that can cope with the diverse needs of the expanding biomedical field and promote the required biological response in multiple applications. Due to their biocompatibility, ability to encapsulate and deliver drugs, and capacity to mimic the extracellular matrix (ECM), typical hydrogels have been extensively investigated in the biomedical and biotechnological fields. The major limitations of hydrogels include poor mechanical integrity and limited cell interaction, restricting their broad applicability. To overcome these limitations, an emerging approach, aimed at the generation of hybrid materials with synergistic effects, is focused on incorporating nanoparticles (NPs) within polymeric gels to achieve nanocomposites with tailored functionality and improved properties. This review focuses on the unique contributions of clay nanoparticles, regarding the recent developments of clay-based nanocomposite hydrogels, with an emphasis on biomedical applications.

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“…Given this, alginate is commonly combined with different materials to originate new hydrogel-based bioinks with enhanced properties. , In this topic, the combination with other biopolymers , (e.g., cellulose, chitosan, or gelatin) or the reinforcement with nanostructures (e.g., nanoparticles, − nanocrystals, and nanofibers , ) is particularly relevant. The development of composite alginate hydrogel-based bioinks is a research field with great potential, with several publications exploring the use of different particles (e.g., hydroxyapatite, silica, or polydopamine), usually to improve the mechanical or rheological properties of the hydrogels or their biological performance, or to grant the inks with new functionalities (e.g., magnetic properties and conductivity). , …”

Section: Introductionmentioning

confidence: 99%

Hydrogel Bioinks of Alginate and Curcumin-Loaded Cellulose Ester-Based Particles for the Biofabrication of Drug-Releasing Living Tissue Analogs

Carvalho

Teixeira

Lameirinhas

et al. 2023

ACS Appl. Mater. Interfaces

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3D bioprinting is a versatile technique that allows the fabrication of living tissue analogs through the layer-by-layer deposition of cell-laden biomaterials, viz. bioinks. In this work, composite alginate hydrogel-based bioinks reinforced with curcumin-loaded particles of cellulose esters (CEpCUR) and laden with human keratinocytes (HaCaT) are developed. The addition of the CEpCUR particles, with sizes of 740 ± 147 nm, improves the rheological properties of the inks, increasing their shear stress and viscosity, while preserving the recovery rate and the mechanical and viscoelastic properties of the resulting fully cross-linked hydrogels. Moreover, the presence of these particles reduces the degradation rate of the hydrogels from 26.3 ± 0.8% (ALG) to 18.7 ± 1.3% (ALG:CEpCUR_10%) after 3 days in the culture medium. The 3D structures printed with the ALG:CEpCUR inks reveal increased printing definition and the ability to release curcumin (with nearly 70% of cumulative release after 24 h in PBS). After being laden with HaCaT cells (1.2 × 10 6 cells mL −1 ), the ALG:CEpCUR bioinks can be successfully 3D bioprinted, and the obtained living constructs show good dimensional stability and high cell viabilities at 7 days post-bioprinting (nearly 90%), confirming their great potential for application in fields like wound healing.

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Nanocomposite bioinks for 3D bioprinting

Cited by 41 publications

References 132 publications

Exosome‐Hydrogel System in Bone Tissue Engineering: A Promising Therapeutic Strategy

Exosome‐Hydrogel System in Bone Tissue Engineering: A Promising Therapeutic Strategy

Clay-Based Nanocomposite Hydrogels for Biomedical Applications: A Review

Hydrogel Bioinks of Alginate and Curcumin-Loaded Cellulose Ester-Based Particles for the Biofabrication of Drug-Releasing Living Tissue Analogs

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