Nanocomplexes Based on Amphiphilic Hyaluronic Acid Derivative and Polyethylene Glycol–Lipid for Ginsenoside Rg3 Delivery

Lee, Jae Eun; Yang, Heejung; Yoon, In‐Soo; Kim, Sang-Bum; Ko, Seung-Hak; Shim, Jae-Seong; Sung, Sang Hyun; Cho, Hyun‐Jong; Kim, Dae‐Duk

doi:10.1002/jps.24111

Cited by 25 publications

(17 citation statements)

References 39 publications

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“…Thus, development and evaluation of a new drug delivery system for saponins is necessary. In vitro and in vivo studies on delivery systems consisting of nanoparticles, such as proliposome [217], phosphatidylcholine, and polyethylene glycol (PEG) [218] were performed, but more thorough studies are still needed.…”

Section: Discussionmentioning

confidence: 99%

Saponins from Chinese Medicines as Anticancer Agents

Fong

et al. 2016

Molecules

132

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Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyphyllin, and timosaponin) isolated from Chinese medicines. These saponins exhibit in vitro and in vivo anticancer effects, such as anti-proliferation, anti-metastasis, anti-angiogenesis, anti-multidrug resistance, and autophagy regulation actions. In addition, related signaling pathways and target proteins involved in the anticancer effects of saponins are also summarized in this work.

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Section: Discussionmentioning

confidence: 99%

Saponins from Chinese Medicines as Anticancer Agents

Fong

et al. 2016

Molecules

132

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“…In contrast, another study of PEG-PLGA-Rg3 nanoparticles exhibited significant cytotoxicity and apoptosis [11]. Besides, the higher serum stability, better uptake, narrow-sized hybrid nanocomplex nanoparticles resulted in longer blood circulation time of (S)-Rg3 in in vivo pharmacokinetic study [12].…”

Section: The Role Of Ginsenoside Nanoconjugates In Treating Cancersmentioning

confidence: 98%

Ginseng Nanoparticles: A Budding Tool for Cancer Treatment

Mathiyalagan

Yang

2017

Nanomedicine (Lond.)

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CancerCancer is one of the most incurable diseases and is a major cause of death worldwide. It is estimated that the annual number of deaths due to cancer will be around 13.2 million by 2030 in all over the world [1]. Although chemotherapy is one of the mainstays for its treatment, the side effects as well as disadvantages, such as, normal cell cytotoxicity, chemoresistance and the ability to prevent the occurrence of cancers have been considered as important hitches. Thus, the complementary and alternative medicines with the utilization of the medicinal and functional food herbs could be an alternative method to combat the progression of cancers. In this juncture, oriental adaptogenic herbs (i.e., ginseng) could be promising candidates for the treatment of cancer as safe, complementary and alternative medicines as well as medicinal and functional food [1,2]. Ginseng & its relations to cancerGinseng or scientifically listed in the Panax species as Panax ginseng (Korean ginseng), P. quinquefolius (American ginseng) and P. notoginseng (Sanchi ginseng) has been considered one of the highly valued medicinal plants in traditional Chinese medicine for more than thousands of years. Commonly, ginseng is also known as 'king of all herbs'. Derived from Latin, 'Panax' means 'all-healing' and 'ginseng' is literally defined as 'essence of men' with its roots resembling

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“…Many cytotoxic drugs have poor water solubility, low circulation half-life, and high non-specific toxicity. So far, LPNs have been used to deliver a variety of small molecule hydrophobic drugs, including docetaxel, 17 salidroside, 13 ginsenoside, 29 paclitaxel, 30 camptothecin, 12 doxorubicin, 27,31,32 sorafenib, 14 and curcumin. 16 Using a single-step nanoprecipitation method, Zhang et al developed LPNs for the delivery of docetaxel to prostate cancer cells.…”

Section: Targeting Tumor Cell Proliferationmentioning

confidence: 99%

Lipid-coated polymeric nanoparticles for cancer drug delivery

et al. 2015

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Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid-polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.

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Nanocomplexes Based on Amphiphilic Hyaluronic Acid Derivative and Polyethylene Glycol–Lipid for Ginsenoside Rg3 Delivery

Cited by 25 publications

References 39 publications

Saponins from Chinese Medicines as Anticancer Agents

Saponins from Chinese Medicines as Anticancer Agents

Ginseng Nanoparticles: A Budding Tool for Cancer Treatment

Lipid-coated polymeric nanoparticles for cancer drug delivery

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