Lipid-coated polymeric nanoparticles for cancer drug delivery

Abstract

Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid-polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

“…Many polymer-based bioactive delivery systems are physical admixtures of the active within the release-controlling polymer or encapsulations of the active within polymeric carrier molecules. 1–12 However, physical incorporation of bioactives into polymeric matrices can suffer from low drug loadings as well as a burst release in which the vast majority of active is released after a short time. 13, 14 …”

Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment

“…[10][11][12][13][14][15][16][17][18] We previously reported the preparation of a new type of hybrid nanoparticle LPNPs using an amphiphilic reduction-sensitive polymer of monomethoxy-poly(ethylene glycol)-S-S-hexadecyl (mPEG-S-S-C 16 ) to achieve intracellular release and then improve the therapeutic effect. [19][20][21] The amphiphilic polymer mPEG-S-S-C 16 containing a disulfide bond could maintain the stability of this formulation and serve as a switch to trigger drug release.…”

Influence of cationic lipid concentration on properties of lipid–polymer hybrid nanospheres for gene delivery

“…[13][14][15] They were designed to have a biodegradable polymer core and lipid layers. 14,16 Depending on their application, specific fabrication methods have been reported. 17 In the past, LPHNSs were prepared by two-step methods that required introducing lipid vesicles into preformed polymeric NSs.…”