Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation

Izquierdo‐Barba, Isabel; García-Martín, José Miguel; Álvarez, Rafael; Palmero, Alberto; Esteban, Jaime; Pérez‐Jorge, Concepción; Arcos, Daniel; Vallet‐Regí, María

doi:10.1016/j.actbio.2014.12.023

Cited by 83 publications

(73 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results demonstrate that bioceramics could be specifically designed to promote osteoblast function while reducing bacterial colonization, which would be particularly pertinent for the successfully fabrication of bone implants. Similar results have been also described for nanostructured surfaces of Ti6Al4V implants [18]. However, the mechanisms regulating the bacterial and cells response to nanostructured surfaces have not been fully elucidated, although they seem to be mainly based on the smaller size and stiffness of the bacteria able to sense entities in the nanoscale [19].…”

Section: Interactions Between Bioceramic Surfaces and Biological Milieusupporting

confidence: 70%

Zwitterionic ceramics for biomedical applications

2016

Self Cite

View full text Add to dashboard Cite

Section: Interactions Between Bioceramic Surfaces and Biological Milieusupporting

confidence: 70%

Zwitterionic ceramics for biomedical applications

2016

Self Cite

View full text Add to dashboard Cite

“…Moreover, researchers have previously reported that nanoroughness alone altered surface energetics, which influenced select enhanced protein adsorption and bioactivity, thereby improving osteoblast adhesion and tissue growth. 21,24,25 Elucidating an exact mechanism of action for the currently observed antibacterial properties on this novel nanostructured PEKK will also be the focus of a future study.…”

mentioning

confidence: 99%

Antibacterial properties of PEKK for orthopedic applications

Wang¹,

Bhardwaj²,

Webster³

2017

IJN

View full text Add to dashboard Cite

Orthopedic implant infections have been steadily increasing while, at the same time, antibiotics developed to kill such bacteria have proven less and less effective with every passing day. It is clear that new approaches that do not rely on the use of antibiotics are needed to decrease medical device infections. Inspired by cicada wing surface topographical features, nanostructured surfaces represent a new approach for imposing antibacterial properties to biomaterials without using drugs. Moreover, new chemistries with altered surface energetics may decrease bacterial attachment and growth. In this study, a nanostructured surface was fabricated on poly-ether-ketone-ketone (PEKK), a new orthopedic implant chemistry, comprised of nanopillars with random interpillar spacing. Specifically, after 5 days, when compared to the orthopedic industry standard poly-ether-ether-ketone (PEEK), more than 37% less Staphylococcus epidermidis were found on the PEKK surface. Pseudomonas aeruginosa attachment and growth also decreased 28% after one day of culture, with around a 50% decrease after 5 days of culture when compared to PEEK. Such decreases in bacteria function were achieved without using antibiotics. In this manner, this study demonstrated for the first time, the promise that nanostructured PEKK has for numerous anti-infection orthopedic implant applications.

show abstract

“…In a very recent publication on nanostructured Ti surfaces prepared by MS-OAD, we have claimed that while the specific topography produced by the vertical nanorods of the layers are effective in stimulating the growth of osteoblasts on their surface, it simultaneously hinders the development of different types of bacteria. This behavior makes these substrates ideal for implants and other applications in which osteointegration must be accompanied by efficient biocide activity [593].…”

Section: Cell-surface Interactionmentioning

confidence: 99%

Perspectives on oblique angle deposition of thin films: From fundamentals to devices

Barranco

Borrás

González‐Elipe

et al. 2016

Progress in Materials Science

Self Cite

583

436

View full text Add to dashboard Cite

a b s t r a c tThe oblique angle configuration has emerged as an invaluable tool for the deposition of nanostructured thin films. This review develops an up to date description of its principles, including the atomistic mechanisms governing film growth and nanostructuration possibilities, as well as a comprehensive description of the applications benefiting from its incorporation in actual devices. In contrast with other reviews on the subject, the electron beam assisted evaporation technique is analyzed along with other methods operating at oblique angles, including, among others, magnetron sputtering and pulsed laser or ion beam-assisted deposition techniques. To account for the existing differences between deposition in vacuum or in the presence of a plasma, mechanistic simulations are critically revised, discussing well-established paradigms such as the tangent or cosine rules, and proposing new models that explain the growth of tilted porous nanostructures. In the second part, we present an extensive description of applications wherein oblique-angle-deposited thin films are of relevance. From there, we proceed by considering the requirements of a large number of functional devices in which these films are currently being utilized (e.g., solar cells, Li batteries, electrochromic glasses, biomaterials, sensors, etc.), and subsequently describe how and why these nanostructured materials meet with these needs.

show abstract

Nanocolumnar coatings with selective behavior towards osteoblast and Staphylococcus aureus proliferation

Cited by 83 publications

References 41 publications

Zwitterionic ceramics for biomedical applications

Zwitterionic ceramics for biomedical applications

Antibacterial properties of PEKK for orthopedic applications

Perspectives on oblique angle deposition of thin films: From fundamentals to devices

Contact Info

Product

Resources

About