Nanocoatings on Implantable Medical Devices

Abstract

The global medical device industry has experienced significant growth over the past 5 years. The surge of patent publications in the field bears testimony to this fact. The advent of nanotechnology has opened up newer unexplored vistas in the field of medical devices. This review summarizes patents employing the principles of nanotechnology in the formulation of coatings for implantable medical devices. Patents selected have at least one entity or structure with dimensions in the nanometer range, which results in a therapeutic value addition. The strategies reviewed pertain to tackling issues such as restenosis and thrombosis in addition to improving the overall acceptability of the implantable medical device, particularly those placed in the vasculature.

Recent Advances in Nanomaterials for Therapy and Diagnosis of Cardiovascular Disease

“…Further study is needed to comprehensively analyze the toxicity, especially chemotoxicity and inflammatory responses. In addition, future work should plan to introduce novel ways to reduce toxicity, represented in Table 3 [77][78][79][80][81][82][83][84][85] and Table 4 [86][87][88][89].…”

Progress in TiO2nanotube coatings for biomedical applications: a review

“…as the fixation devices include interference screws in the ankle, knee, and hand regions, stems and pins for fracture fixation, screws and plates for craniomaxillo facial repair, and bone tissue engineering scaffolds for fractures and implants as autologous bone graft or allograft bone graft. 193 Although traditional prosthetic knee, hip, and plate implants are still the most implantable commercial devices, a great deal of research activity has been initiated over the past decade. The principle behind the application of nanotechnology on bone tissue engineerin, which is related to fracture healing.…”

Delivery of Nanoparticles for the Treatment of Cardiovascular Diseases

“…In summary, the current coating technologies of nanoparticles on cardioavscular implantable stents is an up and coming treatment strategy for the therapy of cardiovascular diseases. Recent Table 1: The superiorities of nanoparticles on cardiovascular implantable devices [14,26,27].…”

“…However, the present implant technology is facing a major difficulty of being perceived by the human body as foreign substances. Nanotechnology provides a medical solution to revolutionize the biomedical implant technology exactly by modifying and designing their structures thereby to overcome these problems [14]. The topic of this review article is to designate the role and the importance of nanocarriers in cardiovascular implant technology.…”