Nanoclay/Polymer-Based Hydrogels and Enzyme-Loaded Nanostructures for Wound Healing Applications

Abstract

Multi-polymeric nanocomposite hydrogels with multi-functional characteristics have been engineered with high interest around the globe. The ease in fine tunability with maintained compliance makes an array of nanocomposite biomaterials outstanding candidates for the biomedical sector of the modern world. In this context, the present work intends to tackle the necessity of alternatives for the treatment of diabetic foot ulcers through the formulation of nanoclay and/or polymer-based nanocomposite hydrogels. Laponite RD, a synthetic 2-D nanoclay that becomes inert when in a physiological environment, while mixed with water, becomes a clear gel with interesting shear-thinning properties. Adding Laponite RD to chitosan or gelatin allows for the modification of the mechanical properties of such materials. The setup explored in this research allows for a promising polymeric matrix that can potentially be loaded with active compounds for antibacterial support in foot ulcers, as well as enzymes for wound debridement.

Engineering functional natural polymer-based nanocomposite hydrogels for wound healing

“… 203 Nanoclay is an ultra-fine polar nanomaterial composed of various nanoparticles, which possess diverse mineral components, and good binding ability and dispersibility compared to silica nanoparticles. 204 Ordeghan et al developed an antibacterial NNPH comprised of nanoclay, collagen and tadalafil, which can effectively accelerate the healing time of wounds and promote hair follicle formation and collagen deposition for diabetic wounds under high-intensity interval training. 205 POSS is a biocompatible hybrid nanostructure comprised of silicon and oxygen, which can achieve multifunctionality through covalent chemical modification of the organic groups.…”

One-step synthesis of super-absorbent nanocomposite hydrogel based on bentonite

“…There are numerous uses for hydrogel in adsorption, biosensors, biomedicine, agriculture, etc [17][18][19]. The use of NB is increasingly favorable to enhance the properties of hydrogels due to its mechanical and thermal strength [20][21][22][23]. A nanocomposite hydrogel was formed through the free-radical polymerization of acrylic acid and acrylamide in the presence of inorganic clay (hectorite) with a 1500.0% of mechanical strength [24].…”

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

“…A variety of nanotherapeutic approaches have been recently introduced for biological applications, including to overcome chemotherapeutic resistance of cancer cells, combat cancer metastasis, etc. [11,13,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Furthermore, thermosensitive magnetic nanomaterials were exposed to alternate magnetic field in order to develop effective chemotherapeutic approaches [34][35][36][37][38].…”